[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606244":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":26,"centralContacts":30,"locations":22,"responsibleParty":39,"collaborators":22,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":22,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":22,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":22},{"fullName":5,"class":6},"Cliniques universitaires Saint-Luc- Université Catholique de Louvain","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"rhGH cohort","Patients with GHD who receive daily rhGH (dose titration according to guidelines i.e. 25-35 micrograms\u002Fkg body weight\u002Fday)",[12],"Other: metabolic and auxological outcomes",{"label":14,"type":6,"description":15,"interventionNames":16},"LAGH cohort","Patients with GHD who receive weekly LAGH (dose titration according to guidelines i.e. for somatrogon 0.66 milligrams\u002Fkg body weight\u002Fweek)",[12],[18,23],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"metabolic and auxological outcomes","Evaluation over a three-year period following the initiation of treatment with daily recombinant human growth hormone (rhGH)",[9],null,{"type":6,"name":19,"description":24,"armGroupLabels":25,"otherNames":22},"Evaluation over a three-year period following the initiation of treatment with weekly long-acting growth hormone (LAGH).",[14],[27],{"name":28,"affiliation":5,"role":29},"Philippe Lysy, MD, PhD","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":22,"email":35},"Laure Boutsen, MD","CONTACT","+32276441370","laure.boutsen@saintluc.uclouvain.be",{"name":37,"role":33,"phone":22,"phoneExt":22,"email":38},"Micheline Grillet, PhD","micheline.grillet@saintluc.uclouvain.be",{"type":40,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100606244","evaluation-of-cardiometabolic-and-auxological-outcomes-of-ghd-patients-under-rhgh-or-lagh-with-stratification-according-to-igf-1-levels-100606244",false,"NCT07173036","Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under rhGH or LAGH With Stratification According to IGF-1 Levels","Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under Recombinant Human or Long-acting Growth Hormone With Stratification According to IGF-1 Levels","METAB-BELGROW","Inclusion Criteria:\n\n* Diagnosed with growth hormone deficiency (GHD)\n* Treated with growth hormone (rhGH or LAGH)\n\nExclusion Criteria:\n\n* No exclusion criteria","ALL","5 Years","18 Years",{"count":53,"type":54},300,"ESTIMATED","INTERVENTIONAL",[57],"NA","The METAB-BELGROW-LAGH study aims to prospectively evaluate the metabolic outcomes of Belgian children diagnosed with growth hormone deficiency (GHD) over a three-year period following the initiation of treatment with either daily recombinant human growth hormone (rhGH) or weekly long-acting growth hormone (LAGH). Patients will be stratified according to their IGF-1 levels. The primary objective is to assess the metabolic outcomes of children treated with daily rhGH over the first three years. The secondary objectives include comparing the metabolic outcomes between patients treated with daily rhGH and those treated with weekly LAGH, and characterizing metabolic profiles based on IGF-1 levels. To achieve these objectives, both standard-of-care (SOC) and additional data will be collected at scheduled follow-up visits (baseline, 6, 12, 24, and 36 months), including clinical, auxological, and biological parameters. Additional metabolic markers, inflammatory and endothelial biomarkers will be assessed. In a subset of patients, carotid intima-media thickness (cIMT) and body fat distribution (via DEXA-scan) will also be measured.",[60],"Growth Hormone Deficiency",[62,63,64,65],"metabolic outcomes","auxological outcomes","recombinant human growth hormone","long acting growth hormone","NOT_YET_RECRUITING","2026-05-08",{"date":69,"type":70},"2026-05-11","ACTUAL",{"date":72,"type":54},"2026-07-01",{"date":74,"type":54},"2031-09-01",{"name":5,"class":6}]