[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623523":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":10,"responsibleParty":30,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":43,"enrollmentInfo":44,"targetDuration":10,"studyType":47,"phases":10,"briefSummary":48,"conditions":49,"keywords":51,"overallStatus":53,"whyStopped":10,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":10},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I",null,"Patients with Rheumatoid Arthritis",[13],"Genetic: Gene expression by quantitative Real Time PCR",{"label":15,"type":10,"description":16,"interventionNames":17},"Group II","apparently healthy controls with no chronic illness of matched age and sex",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"GENETIC","Gene expression by quantitative Real Time PCR","Sample collection:\n\n* 5 ml peripheral blood will be collected under sterile conditions.\n\n  1-Gene Expression Assay\n* Total RNA Extraction\n* cDNA Synthesis\n* Gene Expression Analysis:\n\n  o Quantitative Real-Time PCR (qRT-PCR) for CCR6 gene expression using primer as follows: Forward primer (5'-3'): CCACAATGAGCGGGGAATCAATGAA Reverse primer (5'-3'): CAAATAGCCTGGAGAACTGCCTGAC\n* Normalization using housekeeping gene (GAPDH) Forward primer (5'-3'): GAAACCTGCCAAGTATGATG Reverse primer (5'-3'): AGGAAATGAGCTTGACAAAG 2-Assesment of CCL20 plasma level\n* Using Enzyme Linked Immunosorbent Assay kit (ELISA).",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Salma Khalaf Abdelmageed, Assistant Lecturer","CONTACT","01091285241","salma011101@med.sohag.edu.eg",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Salma Khalaf Abdelmageed","Assistant lecturer of medical biochemistry","100623523","evaluation-of-ccr6-gene-expression-and-circulating-ccl20-levels-as-potential-biomarkers-in-rheumatoid-arthritis-100623523",false,"NCT07397741","Evaluation of CCR6 Gene Expression and Circulating CCL20 Levels as Potential Biomarkers in Rheumatoid Arthritis","Inclusion Criteria:\n\n* Adults (18-60 years) diagnosed with RA according to the American College of Rheumatology\u002FEuropean League Against Rheumatism (ACR\u002FEULAR) 2010 classification criteria for RA by an expert rheumatologist.\n\nExclusion Criteria:\n\n* • Patients with co-existing infections or other autoimmune diseases.",true,"ALL","18 Years","60 Years",{"count":45,"type":46},60,"ESTIMATED","OBSERVATIONAL","Rheumatoid arthritis (RA) is characterized as a systemic auto immune disorder linked to a persistent inflammatory process that can harm both joints and extra articular organs.\n\nThe upregulation of the CCR6\u002FCCL20 axis in the synovial tissues and salivary glands (in cases of secondary Sjögren's syndrome) is considered to contribute to the recruitment of Th17 cells, which in turn enhances IL 17A production and promotes the inflammatory cycle.",[50],"Rhematoid Arthritis",[52],"CCR6\u002FCCL20 axis in Rheumatoid arthritis","NOT_YET_RECRUITING","2026-02-05",{"date":56,"type":57},"2026-02-09","ACTUAL",{"date":59,"type":46},"2026-03-01",{"date":61,"type":46},"2027-03-01",{"name":5,"class":6}]