[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576259":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":27,"responsibleParty":81,"collaborators":83,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":94,"sex":100,"minAge":101,"maxAge":10,"enrollmentInfo":102,"targetDuration":10,"studyType":105,"phases":10,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Clinical Hub for Interventional Research (CHOIR)","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort 1",null,"Individuals diagnosed with or suspected of acute myeloid leukemia (AML) who are not planned for intensive chemotherapy and are commencing venetoclax + azacitidine therapy.",{"label":13,"type":10,"description":14,"interventionNames":10},"Cohort 2","Individuals who have relapsed following, or are refractory to, intensive chemotherapy or hematopoietic stem cell transplantation, commencing venetoclax + azacitidine therapy.",[16],{"name":17,"affiliation":18,"role":19},"John Pimanda, Professor","University of New South Wales","PRINCIPAL_INVESTIGATOR",[21,25],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+61 000000000","cosmos.jcsmr@anu.edu.au",{"name":26,"role":22,"phone":10,"phoneExt":10,"email":24},"Mark Polizzotto, Professor",[28,46,59,69],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Canberra Health Services","RECRUITING","Canberra","Australian Capital Territory","2605","Australia","AU",{"type":37,"coordinates":38},"Point",[39,40],149.12807,-35.28346,{"lat":40,"lon":39},[43],{"name":44,"role":22,"phone":10,"phoneExt":10,"email":45},"Samuel Bennett, Dr","samuel.k.bennett@act.gov.au",{"facility":47,"status":30,"city":48,"state":49,"zip":50,"country":34,"countryCode":35,"cosmosGeoPoint":51,"geoPoint":55,"contacts":56},"Prince of Wales Hospital","Sydney","New South Wales","2031",{"type":37,"coordinates":52},[53,54],151.20732,-33.86785,{"lat":54,"lon":53},[57],{"name":58,"role":22,"phone":10,"phoneExt":10,"email":10},"Mark Hertzberg, Professor",{"facility":60,"status":61,"city":48,"state":49,"zip":62,"country":34,"countryCode":35,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"Royal North Shore Hospital","NOT_YET_RECRUITING","2065",{"type":37,"coordinates":64},[53,54],{"lat":54,"lon":53},[67],{"name":68,"role":22,"phone":10,"phoneExt":10,"email":10},"Jad Othman, Dr",{"facility":70,"status":30,"city":71,"state":49,"zip":72,"country":34,"countryCode":35,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Westmead Hospital","Westmead","2145",{"type":37,"coordinates":74},[75,76],150.98768,-33.80383,{"lat":76,"lon":75},[79],{"name":80,"role":22,"phone":10,"phoneExt":10,"email":10},"Lachlin Vaughan, Dr",{"type":82,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[84,87,90],{"name":85,"class":86},"Cancer Institute NSW","UNKNOWN",{"name":88,"class":89},"The University of New South Wales","OTHER",{"name":91,"class":89},"Australian National University","100576259","evaluation-of-combined-sensitising-and-hypomethylating-therapy-outcomes-in-aml-pdx-100576259",false,"NCT06782971","Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX","COSMOS-Avatar: Evaluation of Combined Sensitising and Hypomethylating Therapy Outcomes in AML PDX","COSMOS-Avatar","Inclusion Criteria:\n\n1. Age 18 years and above\n2. Patients with suspicion of AML requiring screening procedures\n3. Documented diagnosis of AML by WHO Classification and\u002For International Consensus Classification.\n\n   * Regardless of the number and type of prior lines of therapy or eligibility for allogeneic stem cell transplantation.\n   * All AML subtypes are eligible.\n   * Concurrent participation in clinical trials is allowed.\n4. Documented myeloblast percentage ≥20% in the bone marrow or peripheral blood within 12 weeks of C1D1 confirmed by bone marrow aspirate or peripheral blood smear.\n5. Planned to commence venetoclax and azacitidine therapy.\n6. Provision of written informed consent prior to any study-related assessments or procedures being carried out.\n\nExclusion Criteria:\n\n1\\. Presence of any condition that, by assessment of the Investigator, would compromise the safety of the patient if they participated, the quality of trial data, or their adherence to the study-specified procedures.","ALL","18 Years",{"count":103,"type":104},25,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to develop new ways to test new drug combinations to kill tumour cells, in patients with acute myeloid leukemia (AML). The main questions it aims to answer are:\n\n* Are there new ways to speed up discovery of better treatments for AML patients using AML cells from individual from patients in special mice that can accept human tissue?\n* Do these mice show treatment responses that are similar to the individual AML patient from whom cells were derived?\n\nParticipants with AML who are taking standard of care treatment of venetoclax and azacitidine will be asked to donate blood and bone marrow samples for this study.",[108],"AML - Acute Myeloid Leukemia",[110,111,112,113],"AML","Acute Myeloid Leukemia","PDX","Patient-derived xenografts","2025-12-04",{"date":116,"type":117},"2025-12-08","ACTUAL",{"date":119,"type":117},"2025-06-06",{"date":121,"type":104},"2030-03",{"name":5,"class":6},4]