[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568646":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":25,"locations":35,"responsibleParty":248,"collaborators":250,"id":253,"slug":254,"hasResults":255,"nctId":256,"briefTitle":257,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":255,"sex":260,"minAge":261,"maxAge":10,"enrollmentInfo":262,"targetDuration":10,"studyType":265,"phases":10,"briefSummary":266,"conditions":267,"keywords":270,"overallStatus":274,"whyStopped":10,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":284},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients",null,"Adult patients at very high risk of severe SARS-CoV-2 disease, hospitalized for SARS-CoV-2 infection from June 2023 to April 2024.",[13],"Other: Collection of data from the patient's medical file",[15],{"type":6,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"Collection of data from the patient's medical file",[9],[19,22],{"name":20,"affiliation":5,"role":21},"Cléa Melenotte, M.D.","PRINCIPAL_INVESTIGATOR",{"name":23,"affiliation":5,"role":24},"Clémentine de La Porte, M.D.","STUDY_DIRECTOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Cléa Dr Melenotte, M.D.","CONTACT","33142192826","clea.melenotte@aphp.fr",{"name":32,"role":28,"phone":33,"phoneExt":10,"email":34},"Hélène Morel","33171196346","helene.morel@aphp.fr",[36,52,65,78,94,107,120,133,146,162,170,180,193,206,219,232],{"facility":37,"status":10,"city":38,"state":10,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"CHU Angers","Angers","49000","France","FR",{"type":43,"coordinates":44},"Point",[45,46],-0.55202,47.47156,{"lat":46,"lon":45},[49],{"name":50,"role":28,"phone":10,"phoneExt":10,"email":51},"Vincent Dubée, M.D., PhD","vincent.dubee@chu-angers.fr",{"facility":53,"status":10,"city":54,"state":10,"zip":55,"country":40,"countryCode":41,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"CHU Caen","Caen","14000",{"type":43,"coordinates":57},[58,59],-0.35912,49.18585,{"lat":59,"lon":58},[62],{"name":63,"role":28,"phone":10,"phoneExt":10,"email":64},"Frédéric Rivière, M.D.","riviere-f@chu-caen.fr",{"facility":66,"status":10,"city":67,"state":10,"zip":68,"country":40,"countryCode":41,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Hôpital Pasteur, Colmar","Colmar","68000",{"type":43,"coordinates":70},[71,72],7.35584,48.08078,{"lat":72,"lon":71},[75],{"name":76,"role":28,"phone":10,"phoneExt":10,"email":77},"Martin Martinot, M.D.","martin.martinot@ch-colmar.fr",{"facility":79,"status":10,"city":80,"state":10,"zip":81,"country":40,"countryCode":41,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"CHD Vendée (La Roche sur Yon)","La Roche-sur-Yon","85000",{"type":43,"coordinates":83},[84,85],-1.42757,46.66974,{"lat":85,"lon":84},[88,91],{"name":89,"role":28,"phone":10,"phoneExt":10,"email":90},"Sophie Leautez-Nainville, M.D.","sophie.leautez@ght85.fr",{"name":92,"role":28,"phone":10,"phoneExt":10,"email":93},"Thomas Guimard, M.D.","thomas.guimard@ght85.fr",{"facility":95,"status":10,"city":96,"state":10,"zip":97,"country":40,"countryCode":41,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"CHRU Lille","Lille","59000",{"type":43,"coordinates":99},[100,101],3.05512,50.63391,{"lat":101,"lon":100},[104],{"name":105,"role":28,"phone":10,"phoneExt":10,"email":106},"Emmanuel Faure, M.D., PhD","emmanuel.faure2@chu-lille.fr",{"facility":108,"status":10,"city":109,"state":10,"zip":110,"country":40,"countryCode":41,"cosmosGeoPoint":111,"geoPoint":115,"contacts":116},"CHU Nord Marseille","Marseille","13000",{"type":43,"coordinates":112},[113,114],5.38107,43.29695,{"lat":114,"lon":113},[117],{"name":118,"role":28,"phone":10,"phoneExt":10,"email":119},"Carole Eldin, M.D.","carole.eldin@ap-hm.fr",{"facility":121,"status":10,"city":122,"state":10,"zip":123,"country":40,"countryCode":41,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"CHU Nantes","Nantes","44000",{"type":43,"coordinates":125},[126,127],-1.55336,47.21725,{"lat":127,"lon":126},[130],{"name":131,"role":28,"phone":10,"phoneExt":10,"email":132},"Benjamin Gaborit, M.D.","benjamin.gaborit@chu-nantes.fr",{"facility":134,"status":10,"city":135,"state":10,"zip":136,"country":40,"countryCode":41,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"CHU Nîmes Caremeau","Nîmes","30000",{"type":43,"coordinates":138},[139,140],4.35788,43.83665,{"lat":140,"lon":139},[143],{"name":144,"role":28,"phone":10,"phoneExt":10,"email":145},"Paul Loubet, M.D.","Paul.loubet@chu-nimes.fr",{"facility":147,"status":10,"city":148,"state":10,"zip":149,"country":40,"countryCode":41,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Hôpital Saint-Louis","Paris","75010",{"type":43,"coordinates":151},[152,153],2.3488,48.85341,{"lat":153,"lon":152},[156,159],{"name":157,"role":28,"phone":10,"phoneExt":10,"email":158},"Laura Levi, M.D.","laura.levi@aphp.fr",{"name":160,"role":28,"phone":10,"phoneExt":10,"email":161},"Blandine Denis, M.D.","blandine.denis@aphp.fr",{"facility":163,"status":10,"city":148,"state":10,"zip":164,"country":40,"countryCode":41,"cosmosGeoPoint":165,"geoPoint":167,"contacts":168},"Hôpital Necker-Enfants Malades","75015",{"type":43,"coordinates":166},[152,153],{"lat":153,"lon":152},[169],{"name":20,"role":28,"phone":29,"phoneExt":10,"email":30},{"facility":171,"status":10,"city":148,"state":10,"zip":172,"country":40,"countryCode":41,"cosmosGeoPoint":173,"geoPoint":175,"contacts":176},"Hôpital Bichat","75018",{"type":43,"coordinates":174},[152,153],{"lat":153,"lon":152},[177],{"name":178,"role":28,"phone":10,"phoneExt":10,"email":179},"Nathan Peiffer-Smadja, M.D.","nathan.peiffer-smadja@aphp.fr",{"facility":181,"status":10,"city":182,"state":10,"zip":183,"country":40,"countryCode":41,"cosmosGeoPoint":184,"geoPoint":188,"contacts":189},"CH Périgueux","Périgueux","24000",{"type":43,"coordinates":185},[186,187],0.71439,45.18691,{"lat":187,"lon":186},[190],{"name":191,"role":28,"phone":10,"phoneExt":10,"email":192},"Claire Aguilar, M.D.","claire.aguilar@ch-perigueux.fr",{"facility":194,"status":10,"city":195,"state":10,"zip":196,"country":40,"countryCode":41,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"CHU Poitiers","Poitiers","86000",{"type":43,"coordinates":198},[199,200],0.34348,46.58261,{"lat":200,"lon":199},[203],{"name":204,"role":28,"phone":10,"phoneExt":10,"email":205},"Gwenaël Le Moal, M.D., PhD","gwenael.le-moal@chu-poitiers.fr",{"facility":207,"status":10,"city":208,"state":10,"zip":209,"country":40,"countryCode":41,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"CHU Reims","Reims","51100",{"type":43,"coordinates":211},[212,213],4.02853,49.26526,{"lat":213,"lon":212},[216],{"name":217,"role":28,"phone":10,"phoneExt":10,"email":218},"Maxime Hentzien, M.D.","mhentzien@chu-reims.fr",{"facility":220,"status":10,"city":221,"state":10,"zip":222,"country":40,"countryCode":41,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"CHU Sud Réunion","Saint-Pierre","97410",{"type":43,"coordinates":224},[225,226],5.40682,43.29282,{"lat":226,"lon":225},[229],{"name":230,"role":28,"phone":10,"phoneExt":10,"email":231},"Kevin Diallo, M.D.","kevin.diallo@chu-reunion.fr",{"facility":233,"status":10,"city":234,"state":10,"zip":235,"country":40,"countryCode":41,"cosmosGeoPoint":236,"geoPoint":240,"contacts":241},"CHU Toulouse","Toulouse","31000",{"type":43,"coordinates":237},[238,239],1.44367,43.60426,{"lat":239,"lon":238},[242,245],{"name":243,"role":28,"phone":10,"phoneExt":10,"email":244},"Guillaume Martin-Blondel, M.D.","martin-blondel.g@chu-toulouse.fr",{"name":246,"role":28,"phone":10,"phoneExt":10,"email":247},"Adrien Chan Sui Ko, M.D.","chansuiko.a@chu-toulouse.fr",{"type":249,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[251],{"name":252,"class":6},"URC-CIC Paris Descartes Necker Cochin","100568646","evaluation-of-direct-antiviral-treatments-against-sars-cov-2-in-immunocompromised-patients-with-covid-19-a-g2i-study-national-multicenter-observational-and-retrospective-from-june-2023-to-april-2024-100568646",false,"NCT06683937","Evaluation of Direct Antiviral Treatments Against SARS-CoV-2 in Immunocompromised Patients With Covid-19. A G2i Study, National Multicenter Observational and Retrospective From June 2023 to April 2024","COV-ID","Inclusion Criteria:\n\n* Adult patients with SARS-CoV-2 in France, treated in a center participating in the study\n* Symptomatic patients for Covid-19 who have received mono- or dual therapy with nirmatrelvir\u002Fritonavir or remdesivir\n* SARS-CoV-2 positive by PCR on nasopharyngeal swab, ECBC or bronchoalveolar fluid\n* Hospitalization in a ward or day hospital for SARS-CoV-2 infection\n* Patients at very high risk of severe form of SARS-CoV-2\n\n  * Aggressive lymphomas (all types)\n  * Acute lymphocytic leukemia\n  * Acute myeloid leukemia\n  * Acute promyelocytic leukemia\n  * T-cell prolymphocytic leukemia\n  * Primary lymphoma of the central nervous system\n  * Stem cell transplant\n  * Light chain amyloidosis\n  * Chronic lymphocytic leukemia\n  * Multiple myeloma\n  * Hematopoietic stem cell transplant\n  * Solid organ transplant\n  * Being on the waiting list for an organ transplant\n  * Primary immunodeficiency;\n  * HIV patients with CD4 \\\u003C200\u002Fmm3 or with a detectable viral load\n  * Lymphopenia \\\u003C200\u002Fmm3\n  * Neutropenia \\\u003C1000\u002Fmm3 for \\> 1 week\n  * Patients receiving long-term immunosuppressive treatment (period of at least 3 months during treatment during infection) with:\n* anti-CD20 antibodies\n* anti-JAK\n* BTK inhibitors\n* azathioprine\n* cyclophosphamide\n* methotrexate\n* mycophenolate mofetil\n* CAR-T cell gene therapy\n* bi-phenotypic therapeutic antibodies\n* tacrolimus\n* sirolimus\n* long-term corticosteroids (prednisone equivalent dose \\>5mg for 3 months)\n\nExclusion Criteria:\n\n* Opposition formulated (following receipt of the study information note)\n* Patients who received convalescent plasma as first-line treatment for SARS-CoV-2 infection","ALL","18 Years",{"count":263,"type":264},300,"ESTIMATED","OBSERVATIONAL","Due to the lower virulence of circulating Omicron variants and the high seroprevalence of anti-SARS-CoV-2 antibodies, the incidence of cases and deaths related to the SARS-CoV-2 virus has significantly decreased in recent months worldwide. However, these infections remain a major public health problem in severely immunocompromised patients, who have decreased vaccine efficacy and are at higher risk of persistent SARS-CoV-2 viral shedding, relapses, secondary invasive fungal infection, intensive care unit hospitalization, and death than non-immunocompromised patients.\n\nThe research concerns adult patients at very high risk of severe SARS-CoV-2 disease, suffering from SARS-CoV-2 having resulted in hospitalization in a center participating in the study in France between June 1, 2023 and April 1, 2024 and having received mono- or dual therapy with nirmatrelvir\u002Fritonavir or remdesivir in order to carry out an evaluation of direct antiviral treatments against SARS-CoV-2 in these immunocompromised patients suffering from Covid-19.\n\nThe study consists of collecting patient care data from the medical record. Patients will be identified by practitioners at each participating French center.",[268,269],"Immunocompromised Patients","SARS-CoV-2 Disease",[271,272,273],"Immunocompromised patients","SARS-CoV-2 disease","Mono- or dual therapy with nirmatrelvir\u002Fritonavir or remdesivir","NOT_YET_RECRUITING","2025-09-05",{"date":277,"type":278},"2025-09-12","ACTUAL",{"date":280,"type":264},"2025-12-01",{"date":282,"type":264},"2026-06-01",{"name":5,"class":6},16]