[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100456880":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":38,"centralContacts":30,"locations":42,"responsibleParty":63,"collaborators":65,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":30,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":30,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":30,"overallStatus":44,"whyStopped":30,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"City of Hope Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diagnostic (needle biopsy, DDMS-2)","EXPERIMENTAL","Patients undergo needle biopsy for collection of tissue samples. Tissue samples are analyzed using DDMS-2. Patients' medical records are also reviewed.",[13,14,15],"Procedure: Diagnostic Procedure","Other: Electronic Health Record Review","Procedure: Needle Biopsy",[17,26,31],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","Diagnostic Procedure","Analysis via DDMS-2",[9],[23,24,25],"Diagnostic Method","Diagnostic Technique","Diagnostic Test",{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Electronic Health Record Review","Review of medical records",[9],null,{"type":18,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Needle Biopsy","Undergo needle biopsy",[9],[36,37],"Aspiration Biopsy","Puncture Biopsy",[39],{"name":40,"affiliation":5,"role":41},"John H Yim","PRINCIPAL_INVESTIGATOR",[43],{"facility":5,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Duarte","California","91010","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-117.97729,34.13945,{"lat":54,"lon":53},[57,62],{"name":58,"role":59,"phone":60,"phoneExt":30,"email":61},"John H. Yim","CONTACT","626-218-3590","JYim@coh.org",{"name":58,"role":41,"phone":30,"phoneExt":30,"email":30},{"type":64,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR",[66],{"name":67,"class":68},"National Cancer Institute (NCI)","NIH","100456880","evaluation-of-dna-methylation-signatures-for-the-diagnosis-and-management-of-thyroid-nodules-100456880",false,"NCT05229341","Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules","Evaluation of DNA Methylation Signatures in Diagnosis and Management of Thyroid Nodules","Inclusion Criteria:\n\n* Patients without impaired decision-making capacity and who are undergoing needle biopsies for thyroid nodule diagnosis\n* Over the age of 18\n* Any gender, race and ethnicity\n* Patients must provide informed consent prior to use of their tissues and clinical data\n\nExclusion Criteria:\n\n* Children are excluded from the study, since the biology of children thyroid nodules is different from adults","ALL","18 Years",{"count":79,"type":80},1450,"ESTIMATED","INTERVENTIONAL",[83],"NA","This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (small collections of tissue with a needle) from the thyroid to determine whether the participant has a malignant (cancer) or benign (not showing cancer) thyroid tumor. The information learned from this trial may help develop a more accurate test so that patients do not have unnecessary surgeries for nodules that are thought to be suspicious but are actually benign.",[86],"Thyroid Gland Carcinoma","2026-02-20",{"date":89,"type":90},"2026-02-23","ACTUAL",{"date":92,"type":90},"2021-10-22",{"date":94,"type":80},"2026-10-22",{"name":5,"class":6},1]