[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628440":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":37,"responsibleParty":73,"collaborators":18,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":18,"enrollmentInfo":85,"targetDuration":18,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":99,"whyStopped":18,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University of Mississippi Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Purge cleaning","EXPERIMENTAL","Additional flushing of the needle into a separate vial.",[13],"Diagnostic Test: Purge cleaning",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard practice","NO_INTERVENTION","Standard saline flush following lesion sampling",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"DIAGNOSTIC_TEST","Additional flushing of the needle into a separate vial",[9],[25],{"name":26,"affiliation":5,"role":27},"Yanglin Guo, MD","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":18,"email":32},"CONTACT","601-984-5650","yguo@umc.edu",{"name":34,"role":30,"phone":35,"phoneExt":18,"email":36},"Ricardo Ungo, MD","601-984-5660","rungo@umc.edu",[38],{"facility":5,"status":18,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Jackson","Mississippi","39216","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-90.18481,32.29876,{"lat":48,"lon":47},[51,53,55,57,59,61,63,65,67,69,71],{"name":26,"role":30,"phone":52,"phoneExt":18,"email":32},"6019845650",{"name":34,"role":30,"phone":54,"phoneExt":18,"email":36},"6019845660",{"name":34,"role":56,"phone":18,"phoneExt":18,"email":18},"SUB_INVESTIGATOR",{"name":58,"role":56,"phone":18,"phoneExt":18,"email":18},"Walter Rose, MD",{"name":60,"role":56,"phone":18,"phoneExt":18,"email":18},"Mick Kelly",{"name":62,"role":56,"phone":18,"phoneExt":18,"email":18},"George Abraham, MD",{"name":64,"role":56,"phone":18,"phoneExt":18,"email":18},"Michal Senitko, MD",{"name":66,"role":56,"phone":18,"phoneExt":18,"email":18},"Varsha Manucha, MD",{"name":68,"role":56,"phone":18,"phoneExt":18,"email":18},"Agha Baqir, MD",{"name":70,"role":56,"phone":18,"phoneExt":18,"email":18},"Swathi Yarlagadda, MD",{"name":72,"role":56,"phone":18,"phoneExt":18,"email":18},"Syed Abbas, MD",{"type":27,"investigatorFullName":74,"investigatorTitle":75,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Yanglin Guo","Assistant Professor, School of Medicine, Department of Medicine, University of Mississippi Medical Center","100628440","evaluation-of-endobronchial-ultrasound-needle-cleaning-techniques-and-their-impact-on-specimen-contamination-100628440",false,"NCT07461662","Evaluation of Endobronchial Ultrasound Needle Cleaning Techniques and Their Impact on Specimen Contamination","EBUS","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients undergoing standard-of-care EBUS bronchoscopy for evaluation of suspected lung malignancy\n* Patients undergoing sampling of 2 or more lymph node stations during EBUS bronchoscopy\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Age less than 18\n* Recent (1 month or less) radiation or procedural manipulation of lymph node stations that may significantly change lymph node architecture","ALL","18 Years",{"count":86,"type":87},204,"ESTIMATED","INTERVENTIONAL",[90],"NA","Endobronchial ultrasound (EBUS) bronchoscopy is commonly used to sample lymph nodes in patients with suspected or known lung cancer to determine the stage of the disease. Accurate staging is essential as it directly impacts treatment decisions and prognosis. During EBUS procedures, needles are often reused across multiple lymph node stations and are typically flushed with saline between samples. This raises the concern that residual tumor cells may contaminate the samples and could potentially incorrectly upstage disease.\n\nThis prospective study will evaluate the current technique used during EBUS procedures to determine if more intensive cleaning leads to reduced cellular contamination without affecting diagnostics. Patients undergoing an EBUS procedure for diagnosis with a large mass and a high probability of malignancy will be selected for the study. Rapid On-Site Examination (ROSE) will be used at the bedside to determine the presence of abnormal cells. Following the final pass, before moving to the next station, the needle will be flushed with saline as normal and then flushed again into another container to evaluate the presence of residual cells. The outcome may help EBUS needle handling practices and improve lung cancer staging accuracy.\n\nNo additional invasive procedures are performed as part of this study; all analyses utilize material obtained during routine EBUS needle flushing, with no added needle sticks or alteration of clinical care.",[93],"Lung Cancer (Locally Advanced or Metastatic)",[95,96,97,98],"Lung Cancer","Endobronchial ultrasound (EBUS) bronchoscopy","Cytologic Contamination","Cancer Staging","NOT_YET_RECRUITING","2026-03-04",{"date":102,"type":103},"2026-03-10","ACTUAL",{"date":105,"type":87},"2026-04-01",{"date":107,"type":87},"2027-08-31",{"name":5,"class":6},1]