[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626576":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":27,"locations":34,"responsibleParty":52,"collaborators":56,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":11,"eligibilityCriteria":64,"healthyVolunteers":61,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":11,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":11,"overallStatus":37,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"McMaster University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"K sorbate one-time administration followed by washout then placebo one-time administration","EXPERIMENTAL",null,[13],"Other: Potassium sorbate one-time administration followed by washout then placebo one-time administration",{"label":15,"type":10,"description":11,"interventionNames":16},"Placebo one-time administration followed by washout then K sorbate one-time administration",[17],"Other: Placebo one-time administration followed by washout then potassium sorbate one-time administration",[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"Potassium sorbate one-time administration followed by washout then placebo one-time administration","K sorbate 450 mg will be administered with breakfast during testing session 1, followed by a minimum of 2-week washout and then placebo administration with breakfast during testing session 2",[9],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"Placebo one-time administration followed by washout then potassium sorbate one-time administration","Placebo will be administered with breakfast during testing session 1, followed by a minimum of 2-week washout and then K sorbate 450 mg administration with breakfast during testing session 2",[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Natalia McInnes, MD, MSc","CONTACT","19055212100","73794","natalia.mcinnes@mcmaster.ca",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"McMaster University Medical Centre","RECRUITING","Hamilton","Ontario","L8S 4K1","Canada","CA",{"type":44,"coordinates":45},"Point",[46,47],-79.84963,43.25011,{"lat":47,"lon":46},[50],{"name":29,"role":30,"phone":51,"phoneExt":32,"email":33},"9055212100",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Natalia McInnes","Associate Professor",[57],{"name":58,"class":6},"Hamilton Academic Health Sciences Organization","100626576","evaluation-of-food-additive-contributions-to-obesity-pilot-study-1-100626576",false,"NCT07437430","Evaluation of Food Additive Contributions to Obesity: Pilot Study 1","Inclusion Criteria:\n\n* Males and females age 20-80; BMI 30-39 kg\u002Fm2 inclusive; willingness and ability to follow the proposed study interventions and procedures; informed consent.\n\nExclusion Criteria:\n\n* Weight loss of ≥3% in the last 3 months; previous or planned bariatric surgery in the next 1 year; current or planned participation in any structured weight-loss programs; current or recent (within the last 6 months) use of weight-loss-inducing drugs (including GLP-1 agonists); history of frequent intermittent or continuous use of systemic steroids; excessive alcohol consumption; recent or anticipated adjustments to mood, anxiety or anti-psychotic medications; untreated bipolar disorder or attention deficit hyperactivity disorder; eating disorder or any other disorder that may lead to significant weight changes; breastfeeding, pregnancy, planned pregnancy or planned fatherhood in the next 6 months; type 1 diabetes; uncontrolled diabetes mellitus (HbA1C≥9%); diabetes requiring treatment with insulin; aversion to foods that will be served during testing sessions.","ALL","20 Years","80 Years",{"count":69,"type":70},20,"ESTIMATED","INTERVENTIONAL",[73],"NA","The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time administration of K sorbate versus placebo after participants reduce the background consumption of related food additives.",[76],"Obesity (Disorder)","2026-02-21",{"date":79,"type":80},"2026-02-27","ACTUAL",{"date":82,"type":80},"2026-02-10",{"date":84,"type":70},"2026-06",{"name":5,"class":6},1]