[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581018":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":33,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":10,"studyType":50,"phases":10,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":20,"whyStopped":10,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},{"fullName":5,"class":6},"Fondazione IRCCS Policlinico San Matteo di Pavia","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"OHCA patients under 50 years",null,"All the patients suffering from OHCA of medical etiology in Lombardy Region ≤50 years, for whom resuscitation manoeuvres was started by EMS (AREU)",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Enrico Baldi, MD","CONTACT","+39 3293556062","enrico.baldi@unipv.it",[19],{"facility":5,"status":20,"city":21,"state":21,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"RECRUITING","Pavia","27100","Italy","IT",{"type":26,"coordinates":27},"Point",[28,29],9.15917,45.19205,{"lat":29,"lon":28},[32],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Enrico Baldi","MD, PhD - Principal Investigator","100581018","evaluation-of-genetic-molecular-causes-of-out-of-hospital-cardiac-arrest-from-patients-to-families-100581018",false,"NCT06844851","Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families","GenetiCA","Inclusion Criteria:\n\n* All the patients suffering from OHCA of medical etiology in Lombardy Region ≤50 years, for whom resuscitation manoeuvres was started by EMS (AREU)\n\nExclusion Criteria:\n\n* Patients under 18 years old\n* Patients with a non-medical cause of the cardiac arrest","ALL","18 Years","50 Years",{"count":48,"type":49},1725,"ESTIMATED","OBSERVATIONAL","The aims are to define the exact prevalence of hereditary heart diseases in out-of-hospital cardiac arrest (OHCA) patients taking also into account gender, patient and OHCA characteristics, provincial settings and environmental pollution; to stratify the individualized arrhythmic risk of proband's family members to prevent further sudden cardiac deaths; to refine the classification of the variants of uncertain significance (VUS) on genes which can have the capability to drive to molecular alterations leading to arrhythmogenic hereditary heart diseases. A blood sample will be obtained during resuscitation from all the patients aged ≤50 years suffering an OHCA in Lombardy Region and then analysed for genetic variants possibly causative of cardiac diseases. Genetic data will be merged with patient, OHCA and post-resuscitation data thanks to the connection with LombardiaCARe, whilst pollution data will be retrieved from ARPA Lombardia for free. A genetic counselling and clinical-instrumental evaluation of the proband's first-degree family members will be performed if a pathogenic\u002Flikely pathogenic variant or a VUS will be disclosed during the genetic analysis.",[53],"Cardiac Arrest (CA)",[55,56,57],"Out-of-hospital cardiac arrest","genetic","cardiovascular diseases","2026-04-22",{"date":60,"type":61},"2026-04-27","ACTUAL",{"date":63,"type":61},"2021-09-09",{"date":65,"type":49},"2027-12-31",{"name":5,"class":6},1]