[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642564":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":33,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":67,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":10,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Nigde Omer Halisdemir University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Childhood gingivitis group",null,"Systemically healthy children aged 8-12 years diagnosed with gingivitis who will undergo clinical periodontal examination and gingival crevicular fluid biomarker analysis.",[13],"Diagnostic Test: Gingival Crevicular Fluid Biomarker Assessment",{"label":15,"type":10,"description":16,"interventionNames":17},"Young adult gingivitis group","Systemically healthy young adults aged 15-24 years diagnosed with gingivitis who will undergo clinical periodontal examination and gingival crevicular fluid biomarker analysis.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Gingival Crevicular Fluid Biomarker Assessment","Gingival crevicular fluid (GCF) samples will be collected from a standardized tooth (#31) using sterile absorbent paper strips (Periopaper®). Samples will be obtained after isolation and drying of the sampling site to avoid saliva contamination. Each strip will be placed gently in the gingival sulcus until mild resistance is felt and maintained for 30 seconds.\n\nCollected samples will be immediately stored at -80°C until laboratory analysis. Levels of inflammatory and anti-inflammatory biomarkers including IL-1β, TNF-α, IL-10, and MMP-8 will be quantified using enzyme-linked immunosorbent assay (ELISA) kits according to manufacturer instructions.\n\nThis procedure is non-invasive and performed for diagnostic and comparative biomarker analysis purposes only.",[9,15],[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Aycan Dal Dönertaş","CONTACT","+903382252595","aycandal@outlook.com",{"name":31,"role":27,"phone":10,"phoneExt":10,"email":32},"Selcen Özcan Bulut","selcen_ozcan@hotmail.com",[34],{"facility":35,"status":36,"city":37,"state":10,"zip":38,"country":39,"countryCode":10,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Niğde Ömer Halisdemir University Faculty of Dentistry","RECRUITING","Niğde","51240","Turkey (Türkiye)",{"type":41,"coordinates":42},"Point",[43,44],34.67935,37.96583,{"lat":44,"lon":43},[47],{"name":48,"role":27,"phone":49,"phoneExt":10,"email":50},"Merdan Doğan","905422076565","merdan@ohu.edu.tr",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100642564","evaluation-of-gingival-crevicular-fluid-cytokine-profiles-in-children-and-young-adults-with-gingivitis-100642564",false,"NCT07607639","Evaluation of Gingival Crevicular Fluid Cytokine Profiles in Children and Young Adults With Gingivitis","Comparison of Gingival Crevicular Fluid Biomarkers Between Childhood Gingivitis and Adolescent Gingivitis","Inclusion Criteria:\n\n1. Individuals aged 8-12 years (child group) or 15-24 years (young adult group)\n2. Clinical diagnosis of gingivitis\n3. Presence of fully erupted tooth #31 with closed apex\n4. Systemically healthy individuals\n5. No history of periodontal treatment in the last 3 months\n6. No antibiotic or anti-inflammatory drug use in the last 3 months\n7. Good cooperation and willingness to participate\n8. Written informed consent from participants or legal guardians (for minors)\n\nExclusion Criteria:\n\n1. Age 13-14 years (transitional pubertal period)\n2. Presence of periodontitis or other periodontal diseases\n3. Systemic, genetic, or immunological diseases\n4. Acute oral infections or conditions requiring emergency treatment\n5. Orthodontic appliances in the sampling region\n6. Smokers\n7. Pregnant or lactating individuals\n8. Individuals with cognitive, psychological, or physical disabilities affecting cooperation\n9. Inadequate eruption or incomplete root development of tooth #31\n10. Refusal to participate or withdrawal of consent",true,"ALL","8 Years","24 Years",{"count":65,"type":66},80,"ESTIMATED","1 Day","OBSERVATIONAL","This prospective observational case-control study aims to compare gingival crevicular fluid (GCF) biomarker profiles between children and young adults diagnosed with gingivitis. A total of approximately 80 systemically healthy participants will be recruited and divided into two groups: children aged 8-12 years and young adults aged 15-24 years. Individuals aged 13-14 years will be excluded as they represent a transitional pubertal period characterized by significant hormonal fluctuations that may influence inflammatory responses and confound biomarker levels.\n\nClinical periodontal parameters including gingival index, plaque index, bleeding on probing, and probing depth will be recorded. In addition, GCF samples will be collected from a standardized tooth and analyzed for levels of IL-1β, TNF-α, IL-10, and MMP-8 using enzyme-linked immunosorbent assay (ELISA).\n\nThe primary objective of the study is to evaluate and compare inflammatory and anti-inflammatory cytokine profiles between the two age groups. The findings may contribute to understanding age-related differences in gingival inflammatory responses and the potential role of hormonal transition in periodontal disease expression during childhood and early adulthood.",[71],"Gingivitis","2026-06-08",{"date":74,"type":75},"2026-06-10","ACTUAL",{"date":77,"type":75},"2026-05-22",{"date":79,"type":66},"2027-11",{"name":5,"class":6},1]