[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100362351":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":61,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Institute of Hematology & Blood Diseases Hospital, China","OTHER",[8,14,17,20],{"label":9,"type":10,"description":11,"interventionNames":12},"30 immune thrombocytopenia(ITP) patients",null,"A total of 30 cases. The investigators plan to take 20ml of peripheral blood (PB) of these 30 ITP patients at 6 time points, including 1 day before surgery, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery",[13],"Procedure: splenectomy",{"label":15,"type":10,"description":16,"interventionNames":10},"20 normal controls","A total of 20 cases.18 age- and gender- matched healthy donor will also be enrolled as controls and taken 20ml of peripheral blood.",{"label":18,"type":10,"description":19,"interventionNames":10},"Spleens of the 30 cases patients(ITP)","These 30 ITP patients agree to have splenectomy.The investigators will take a small amount of spleen tissue during surgery.",{"label":21,"type":10,"description":22,"interventionNames":10},"Spleens of the 10 cases patients(normal controls)","The investigators also plan to take splenic tissue from 10 patients who have splenectomy due to hereditary spherocytosis or trauma.",[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"PROCEDURE","splenectomy","These patients should fail to have sustained response to multiple first- and second-line treatments of ITP and agree to have splenectomy.Before splenectomy, these patients will be reassessed and still diagnosed with ITP.Their platelet level will be raised to a safe state before surgery, and the laparoscopic splenectomy will be performed in Tianjin People's Hospital.",[9],[30],{"name":31,"affiliation":32,"role":33},"Lei Zhang, MD","Chinese Academy of Medical Science and Blood Disease Hospital","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Yunfei Chen, MD","CONTACT","+86-22-23909009","chenyunfei@ihcams.ac.cn",{"name":31,"role":37,"phone":41,"phoneExt":10,"email":42},"+86-22-23909240","zhanglei1@ihcams.ac.cn",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Yunfei Chen","RECRUITING","Tianjin","Tianjin Municipality","300020","China","CN",{"type":53,"coordinates":54},"Point",[55,56],117.17667,39.14222,{"lat":56,"lon":55},[59],{"name":60,"role":37,"phone":38,"phoneExt":10,"email":39},"Yunfei Chen, Doctor",{"type":62,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100362351","evaluation-of-immune-status-before-and-after-splenectomy-in-immune-thrombocytopenia-patients-100362351",false,"NCT03998059","Evaluation of Immune Status Before and After Splenectomy in Immune Thrombocytopenia Patients","Inclusion Criteria:\n\n* Aged 18 to 60 years old, male or female;\n* Conform to the diagnostic criteria of immune Thrombocytopenia (ITP)\n* Needed splenectomy;\n* People who are willing to sign the informed consent voluntarily and follow the research program.\n\nExclusion Criteria:\n\n* Secondary thrombocytopenic purpura;\n* Patients with poor compliance;\n* Researchers believe that patients should not participate in the test of any other condition.",true,"ALL","18 Years","60 Years",{"count":74,"type":75},50,"ESTIMATED","OBSERVATIONAL","Evaluation of immune status before and after splenectomy in immune thrombocytopenia patients.",[79,80],"Thrombocytopenia","Splenectomy",[79,26],"2025-02-20",{"date":84,"type":85},"2025-02-24","ACTUAL",{"date":87,"type":85},"2019-01-23",{"date":89,"type":75},"2025-07-23",{"name":5,"class":6},1]