[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519024":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":203,"collaborators":25,"id":205,"slug":206,"hasResults":207,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":207,"sex":213,"minAge":214,"maxAge":25,"enrollmentInfo":215,"targetDuration":25,"studyType":218,"phases":219,"briefSummary":221,"conditions":222,"keywords":226,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":242},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"VA-ECMO patients with parallel connection","ACTIVE_COMPARATOR","Patients undergoing VA ECMO with indication for concomitant RRT, assigned to parallel connection group.",[13],"Procedure: Parallel connection",{"label":15,"type":10,"description":16,"interventionNames":17},"VA-ECMO patients with integrated connection","Patients undergoing VA ECMO with indication for concomitant RRT, assigned to integrated connection group.",[18],"Procedure: Integrated connection",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Parallel connection","The RRT machine is connected on a separate vascular access (dialysis catheter).",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Integrated connection","A connection of the RRT machine with the input and output lines directly on the ECMO circuit.",[15],[31],{"name":32,"affiliation":5,"role":33},"Frank BIDAR, MD","STUDY_CHAIR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","(33) 472 116 942","frank.bidar@chu-lyon.fr",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Thomas RIMMELE, Professor MD","(33) 472 111 327","thomas.rimmele@chu-lyon.fr",[44,61,74,89,102,117,130,143,156,166,179,193],{"facility":45,"status":46,"city":47,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"CHU de Bordeaux, GH Sud, Service d'anesthésie-réanimation cardiovasculaire, Hôpital cardiologique","RECRUITING","Bordeaux","France","FR",{"type":51,"coordinates":52},"Point",[53,54],-0.58046,44.84124,{"lat":54,"lon":53},[57],{"name":58,"role":36,"phone":59,"phoneExt":25,"email":60},"Alexandre OUATTARA, Professor MD","(33) 557 656 866","alexandre.ouattara@chu-bordeaux.fr",{"facility":62,"status":46,"city":63,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"CHU de Clermont Ferrand, Pôle de médecine péri-opératoire\u002FChirurgie cardiaque, Hôpital Gabriel Montpied","Clermont-Ferrand",{"type":51,"coordinates":65},[66,67],3.08682,45.77969,{"lat":67,"lon":66},[70],{"name":71,"role":36,"phone":72,"phoneExt":25,"email":73},"Vedat ELJEZI, Professor MD","(33) 473 751 590","veljezi@chu-clermontferrand.fr",{"facility":75,"status":46,"city":76,"state":25,"zip":77,"country":48,"countryCode":49,"cosmosGeoPoint":78,"geoPoint":82,"contacts":83},"Centre Hospitalo Universitaire de Dijon, Unité Réanimation Cardio-Vasculaire,","Dijon","21079",{"type":51,"coordinates":79},[80,81],5.01391,47.31344,{"lat":81,"lon":80},[84],{"name":85,"role":36,"phone":86,"phoneExt":87,"email":88},"Pierre-Grégoire GUINOT, Professor MD","03.80.29.56.03","+33","pierregregoire.guinot@chu-dijon.fr",{"facility":90,"status":46,"city":91,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"CHU de Grenoble, Service de réanimation cardiovasculaire et thoracique, Pôle anesthésie réanimation, Hôpital Nord","Grenoble",{"type":51,"coordinates":93},[94,95],5.71479,45.17869,{"lat":95,"lon":94},[98],{"name":99,"role":36,"phone":100,"phoneExt":25,"email":101},"Géraldine DESSERTAINE, MD","(33) 476 767 588","Gdessertaine@chu-grenoble.fr",{"facility":103,"status":104,"city":105,"state":25,"zip":106,"country":48,"countryCode":49,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Centre Hospitalo Universitaire de Lille, Institut Coeur Poumon","NOT_YET_RECRUITING","Lille","59037",{"type":51,"coordinates":108},[109,110],3.05512,50.63391,{"lat":110,"lon":109},[113],{"name":114,"role":36,"phone":115,"phoneExt":87,"email":116},"Mouhamed Djahoum MOUSSA, MD","03 20 44 59 62","mouhamed.MOUSSA@chu-lille.fr",{"facility":118,"status":46,"city":119,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Hospices Civils de Lyon, Service d'Anesthésie-Réanimation cardiovasculaire, Hôpital Louis Pradel","Lyon",{"type":51,"coordinates":121},[122,123],4.84789,45.74906,{"lat":123,"lon":122},[126],{"name":127,"role":36,"phone":128,"phoneExt":25,"email":129},"Jean-Luc FELLAHI, Professor MD","(33) 472 118 933","Jean-luc.fellahi@chu-lyon.fr",{"facility":131,"status":46,"city":132,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":133,"geoPoint":137,"contacts":138},"CHU de Montpellier, Département d'anesthésie-réanimation, Pôle Cœur-poumons, Hôpital Arnaud de Villeneuve","Montpellier",{"type":51,"coordinates":134},[135,136],3.87635,43.61093,{"lat":136,"lon":135},[139],{"name":140,"role":36,"phone":141,"phoneExt":25,"email":142},"Philippe GAUDARD, MD","(33) 467 335 958","p-gaudard@chu-montpellier.fr",{"facility":144,"status":46,"city":145,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":146,"geoPoint":150,"contacts":151},"APHP, Institut de Cardiologie, Service d'anesthésie-réanimation cardiovasculaire, Hôpital de la Pitié-Salpêtrière","Paris",{"type":51,"coordinates":147},[148,149],2.3488,48.85341,{"lat":149,"lon":148},[152],{"name":153,"role":36,"phone":154,"phoneExt":25,"email":155},"Adrien BOUGLE, MD","(33) 142 162 259","Adrien.bougle@aphp.fr",{"facility":157,"status":46,"city":145,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":158,"geoPoint":160,"contacts":161},"APHP, Institut de cardiologie, Service de Médecine Intensive Réanimation, Hôpital Pitié-Salpêtrière",{"type":51,"coordinates":159},[148,149],{"lat":149,"lon":148},[162],{"name":163,"role":36,"phone":164,"phoneExt":25,"email":165},"Charles-Edouard LUYT, Professor MD","(33) 142 163 824","Charles-edouard.luyt@aphp.fr",{"facility":167,"status":46,"city":168,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"CHU de Saint Etienne, Hôpital Bellevue, Service de Réanimation polyvalente et soins intensifs post-opératoires","Saint-Etienne",{"type":51,"coordinates":170},[171,172],4.39,45.43389,{"lat":172,"lon":171},[175],{"name":176,"role":36,"phone":177,"phoneExt":25,"email":178},"Jérôme MOREL, Professor MD","(33) 477 828 329","Jerome.morel@chu-st-etienne.fr",{"facility":180,"status":104,"city":181,"state":25,"zip":182,"country":48,"countryCode":49,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"Centre Hospitalo Universitaire de Toulouse, Hôpital Rangueil - Réanimation polyvalente","Toulouse","31059",{"type":51,"coordinates":184},[185,186],1.44367,43.60426,{"lat":186,"lon":185},[189],{"name":190,"role":36,"phone":191,"phoneExt":87,"email":192},"Fanny VARDON, MD","05 61 32 23 11","vardon.f@chu-toulouse.fr",{"facility":194,"status":104,"city":181,"state":25,"zip":182,"country":48,"countryCode":49,"cosmosGeoPoint":195,"geoPoint":197,"contacts":198},"Centre Hospitalo Universitaire de Toulouse, Unité de Chirurgie Cardiaque",{"type":51,"coordinates":196},[185,186],{"lat":186,"lon":185},[199],{"name":200,"role":36,"phone":201,"phoneExt":87,"email":202},"François LABASTE, MD","05 61 32 28 22","labaste.f@chu-toulouse.fr",{"type":204,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100519024","evaluation-of-integrated-versus-parallel-connection-for-renal-replacement-therapy-in-ecmo-patients-100519024",false,"NCT06038162","Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients","Evaluation of Integrated Versus Parallel Continuous Renal Replacement Therapy Connection in ECMO Patients: a Randomized Controlled Trial","EPIC-ECMO","Inclusion Criteria:\n\n* Patients aged above 18 years\n* Patient on VA-ECMO who requires the initiation of continuous RRT during VA-ECMO treatment\n* Patient with a foreseeable length of stay in intensive care greater than 24 hours\n\nExclusion Criteria:\n\n* Patient who does not have a vascular capital allowing for the insertion of a new dialysis catheter to administer RRT and therefore cannot be randomized to the parallel connection group\n* High pressures monitored on ECMO not allowing direct RRT catherter on ECMO\n* Pregnant, parturient, or breastfeeding women\n* Patient deprived of liberty by a judicial or administrative decision\n* Patient under psychiatric care\n* Patient subject to a legal protection measure (guardianship, curators)\n* Patient not affiliated to a social security system\n* Patient participating in another interventional research study in the field of extra purification renal","ALL","18 Years",{"count":216,"type":217},158,"ESTIMATED","INTERVENTIONAL",[220],"NA","Extracorporeal membrane oxygenation (ECMO) is an extra-corporeal assistance used in case of respiratory or circulatory failure. In case of circulatory failure, ECMO is in the veno-arterial configuration (VA-ECMO). VA-ECMO patients are at high risk of developing acute kidney injury (AKI) and renal replacement therapy (RRT) may be needed in 50% of ECMO patients. Although the administration of RRT in ECMO patients has major implications, no specific recommendations are currently available. The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) international conference identified the evaluation of RRT in these ECMO patients as a research priority.\n\nIn 2023, the two main configurations used to administer RRT in ECMO patients are an independent delivery on a separate vascular access (parallel connection) or an integration of the RRT machine directly into the ECMO circuit (integrated connection). The integrated connection may reduce infectious and bleeding complications associated with the use of a second vascular access. However, it can expose the hemofilter and circuit to excessive positive pressures that can trigger pressure alarms in the RRT machine and expose the patient to a theoretical risk of air embolism or hemolysis. Furthermore, there is currently no robust data comparing the hemofilter lifespan with the parallel or with the integrated connection, although the filter lifespan is a crucial parameter to assess the quality of the RRT delivery in the ICU. The investigators recently performed a survey of practices in this context of ECMO patients. The investigators found that both strategies (parallel and integrated connection) are widely used and can be seen as common patient care.\n\nThe hypothesis tested in this study is the following: when RRT is integrated to the ECMO circuit, the hemofilter lifespan is non inferior to the one when RRT is delivered on a separate vascular access. Only VA-ECMO patients will be enrolled in this trial.",[223,224,225],"Venoarterial Extracorporeal Membrane Oxygenation","Renal Replacement Therapy","Acute Kidney Injury",[227,228,229,230,231,232],"VA-ECMO","RRT","connection","integrated","parallel","hemofilter","2026-01-16",{"date":235,"type":236},"2026-01-20","ACTUAL",{"date":238,"type":236},"2024-02-07",{"date":240,"type":217},"2028-04-07",{"name":5,"class":6},12]