[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617904":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":42,"collaborators":26,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":26,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":26,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":69,"whyStopped":26,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":26},{"fullName":5,"class":6},"Ankara City Hospital Bilkent","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"General Anesthesia (GA) Group","ACTIVE_COMPARATOR","Adult patients undergoing elective forearm fracture surgery under general anesthesia. Standard noninvasive monitoring will be used and perioperative hemodynamic variables and analgesic use will be recorded. Blood samples for serum irisin will be collected preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively.",[13],"Procedure: General Anesthesia (GA)",{"label":15,"type":16,"description":17,"interventionNames":18},"Infraclavicular Block (ICB) Group","EXPERIMENTAL","Adult patients undergoing elective forearm fracture surgery with an ultrasound-guided infraclavicular brachial plexus block performed approximately 1 hour before surgery under monitored conditions. Standard noninvasive monitoring will be used; perioperative hemodynamic variables and analgesic use will be recorded. Blood samples for serum irisin will be collected preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively.",[19],"Procedure: Infraclavicular Brachial Plexus Blocks",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","General Anesthesia (GA)","General anesthesia administered according to institutional routine; anesthetic drugs and doses will be recorded.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Infraclavicular Brachial Plexus Blocks","Ultrasound-guided infraclavicular block performed preoperatively; details of technique, local anesthetic drugs and doses will be recorded.",[15],[32],{"name":33,"affiliation":34,"role":35},"sumru sekerci, professor","Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation, Ankara, Çankaya","STUDY_DIRECTOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"yusuf aynigul, resident","CONTACT","+905522096781","aynigulyusuff@gmail.com",{"type":43,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100617904","evaluation-of-irisin-levels-in-adult-forearm-fracture-surgery-under-infraclavicular-block-and-general-anesthesia-100617904",false,"NCT07324681","Evaluation of Irisin Levels in Adult Forearm Fracture Surgery Under Infraclavicular Block and General Anesthesia","Evaluation of Irisin Levels in Adult Patients With Forearm Fractures Undergoing Surgery With Infraclavicular Block and General Anesthesia","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n\nScheduled for elective forearm fracture surgery\n\nPlanned to receive either general anesthesia or infraclavicular brachial plexus block\n\nAmerican Society of Anesthesiologists (ASA) physical status I-III\n\nAble to provide written and verbal informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years or \\>65 years\n\nEmergency surgery\n\nRefusal or inability to provide informed consent\n\nASA physical status IV or V\n\nKnown bone diseases or metabolic bone disorders\n\nMultiple trauma or associated organ injury\n\nInability to mobilize\n\nMorbid obesity (BMI \\>40 kg\u002Fm²)\n\nRenal failure\n\nHepatic failure\n\nNeurological deficits or sequelae\n\nContraindication or allergy to any anesthetic agents used in the study","ALL","18 Years","65 Years",{"count":55,"type":56},90,"ESTIMATED","INTERVENTIONAL",[59],"NA","This randomized prospective study evaluates the effect of general anesthesia versus infraclavicular nerve block on perioperative serum irisin levels in adults undergoing forearm fracture surgery. Irisin levels will be measured preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively. The association between irisin changes and fracture healing will be explored as a secondary outcome.",[62,63,64],"Inflamation","Healing","Angiogenesis",[66,67,68],"irisin","infraclavicular block","forearm fracture","NOT_YET_RECRUITING","2026-01-07",{"date":72,"type":73},"2026-01-09","ACTUAL",{"date":75,"type":56},"2026-01-25",{"date":77,"type":56},"2026-05-05",{"name":5,"class":6}]