[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100598779":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":43,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":59,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":10,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Kanuni Sultan Suleyman Training and Research Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Weaning Candidates",null,"This group includes adult ICU patients who are receiving mechanical ventilation and have met standardized weaning criteria. All patients in this cohort will undergo transthoracic echocardiographic (TTE) assessment before extubation, without any experimental intervention applied.",[13],"Diagnostic Test: Echocardiographic Assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Echocardiographic Assessment","All participants will receive a standardized transthoracic echocardiographic (TTE) examination within 2 hours after meeting weaning criteria. The following cardiac function parameters will be recorded:\n\nLVOT Velocity Time Integral (VTI)\n\nMitral Annular Plane Systolic Excursion (MAPSE)\n\nE\u002Fe' ratio\n\nE\u002FA ratio\n\nMitral Deceleration Time (MDT)\n\nMyocardial Performance Index (Tei index)\n\nThe echocardiographic data will be used to investigate the association between left ventricular function and weaning success.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Engin ihsan Turan, principal investigator","CONTACT","+905382431114","enginihsan@hotmail.com",[27],{"facility":28,"status":29,"city":30,"state":30,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital","RECRUITING","Istanbul","34303","Turkey (Türkiye)",{"type":34,"coordinates":35},"Point",[36,37],28.94966,41.01384,{"lat":37,"lon":36},[40],{"name":41,"role":23,"phone":42,"phoneExt":10,"email":25},"Engin ihsan Turan, Principal investigator","05382431114",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Engin Ihsan Turan","principal investigator","100598779","evaluation-of-left-ventricular-function-to-predict-weaning-success-in-the-intensive-care-unit-100598779",false,"NCT07075926","Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit","Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study","Inclusion Criteria:\n\n* Currently receiving mechanical ventilation in the ICU\n* Planned extubation after meeting standard weaning criteria\n* Hemodynamically stable at the time of echocardiographic evaluation\n* Written informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\n* Surgery within the previous 24 hours\n* Presence of significant valvular heart disease or known cardiomyopathy\n* Inadequate acoustic window for transthoracic echocardiography\n* Ongoing use of extracorporeal support (e.g., ECMO)\n* Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours\n* Re-intubation planned prophylactically regardless of clinical status\n* Pregnant patients","ALL","18 Years",{"count":57,"type":58},50,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this prospective observational study is to evaluate whether left ventricular function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success from mechanical ventilation in adult intensive care unit (ICU) patients. The main questions it aims to answer are:\n\nCan the Left Ventricular Outflow Tract Velocity Time Integral (LVOT VTI) predict successful extubation?\n\nWhat is the prognostic value of other echocardiographic measures such as Mitral Annular Plane Systolic Excursion (MAPSE), E\u002Fe' ratio, E\u002FA ratio, Mitral Deceleration Time (MDT), and Myocardial Performance Index (Tei index) in forecasting weaning outcomes?\n\nParticipants will:\n\nBe adults receiving mechanical ventilation and scheduled for weaning\n\nUndergo transthoracic echocardiography (TTE) within 2 hours after meeting weaning criteria\n\nHave the following parameters measured: LVOT VTI, MAPSE, E\u002Fe', E\u002FA, MDT, and Tei index\n\nBe monitored for 24 hours post-extubation to determine if they remain off ventilatory support, including reintubation, non-invasive ventilation, or high-flow oxygen therapy\n\nThis study aims to provide a comprehensive understanding of how systolic, diastolic, and global cardiac functions influence extubation success, potentially improving ICU decision-making and reducing complications, length of stay, and healthcare costs.",[63],"Weaning Failure of Mechanical Ventilation","2025-09-02",{"date":66,"type":67},"2025-09-09","ACTUAL",{"date":69,"type":67},"2025-07-31",{"date":71,"type":58},"2026-07-16",{"name":5,"class":6},1]