[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100454455":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":17,"centralContacts":22,"locations":31,"responsibleParty":50,"collaborators":53,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,12,14],{"label":9,"type":10,"description":11,"interventionNames":10},"Children with spastic cerebral palsy",null,"Children between 6 months and 9 years old.",{"label":13,"type":10,"description":11,"interventionNames":10},"Typically developing children",{"label":15,"type":10,"description":16,"interventionNames":10},"Children with an acquired brain injury","Children between 1,5 years and 9 years.",[18],{"name":19,"affiliation":20,"role":21},"Kaat Desloovere, Prof. dr.","Department of Rehabilitation Sciences, KU Leuven, Belgium","PRINCIPAL_INVESTIGATOR",[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Nathalie De Beukelaer","CONTACT","+3216341016","Nathalie.debeukelaer@kuleuven.be",{"name":29,"role":25,"phone":10,"phoneExt":10,"email":30},"Lauraine Staut","lauraine.staut@kuleuven.be",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"UZ Leuven","RECRUITING","Leuven","Vlaams-Brabant","3000","Belgium","BE",{"type":41,"coordinates":42},"Point",[43,44],4.70093,50.87959,{"lat":44,"lon":43},[47],{"name":19,"role":25,"phone":48,"phoneExt":10,"email":49},"+3216338009","kaat.desloovere@kuleuven.be",{"type":21,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Kaat Desloovere","Prof. dr.",[54,57],{"name":55,"class":56},"Pulderbos revalidatiecentrum","UNKNOWN",{"name":58,"class":56},"Revalidatieziekenhuis Inkendaal","100454455","evaluation-of-macroscopic-muscle-growth-in-infants-and-young-children-with-spastic-cerebral-palsy-100454455",false,"NCT05197764","Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy","The Integration of Macroscopic and Microscopic Muscle Properties With Cell Modelling to Feature Altered Neuromuscular Behavior in Cerebral Palsy: 3D-Macroscopic Muscle Architecture in Cerebral Palsy","3D-MMAP","Inclusion Criteria:\n\n* Confirmed diagnosis of spastic cerebral palsy or patients at high-risk for spastic cerebral palsy\n* Suspected GMFCS levels I-III (GMFCS = Gross Motor Function Classification Scale, expressing the overall functional level of impairment)\n\nExclusion Criteria:\n\n* Non-ambulatory\n* Botulinum neurotoxin type-A injections six months prior to enrollment\n* Lower limb surgery two years prior to enrollment\n* Muscle surgery at the muscles in the lower limb\n* Selective dorsal rhizotomy as treatment history\n* Presence of ataxia or dystonia\n* Severe co-morbidities (severe epilepsy, severe behavior problems that impede the cooperation)",true,"ALL","6 Months","9 Years",{"count":72,"type":73},229,"ESTIMATED","OBSERVATIONAL","A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP). Therefore, this project aims to (1) describe the macroscopic morphological muscle changes with increasing age and (2) evaluate the onset and development of muscle alterations in relation to the brain lesion (e.g., timing, extent and location), to the neuromuscular impairments and to treatment. Overall, this project will evaluate the macroscopic muscle properties by means of 3D freehand ultrasound (3DfUS).",[77,78],"Spastic Cerebral Palsy","Acquired Brain Injury",[77,78,80,81,82,83,84,85],"Brain imaging","3D freehand ultrasound","Muscle morphology","Range of motion","Stiffness","Spasticity","2026-02-09",{"date":88,"type":89},"2026-02-12","ACTUAL",{"date":91,"type":89},"2019-02-11",{"date":93,"type":73},"2026-12",{"name":5,"class":6},1]