[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643292":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":59,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":63,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":74,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":84,"whyStopped":10,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Pregnant women who deliver neonates presenting hypoxia",null,"Participants will include term singleton pregnancies undergoing labor and delivery with available intrapartum cardiotocography (CTG) recordings and umbilical cord arterial blood gas analysis. Two cohorts will be included: a retrospective cohort of eligible deliveries occurring between 2018 and 2025 and a prospective cohort of consecutively enrolled term pregnancies from 2026 onward. This is an observational study with no experimental intervention, treatment allocation, or modification of standard clinical care. The study involves collection of clinical data and re-evaluation of CTG tracings using a physiology-based interpretation framework combined with assessment of cord blood gas parameters, including eucapnic pH.",[13],{"name":14,"affiliation":5,"role":15},"Tullio Ghi, Chief","STUDY_DIRECTOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Silvio Tartaglia, MD, PhD","CONTACT","+390630157024","silvio.tartaglia@policlinicogemelli.it",{"name":23,"role":19,"phone":20,"phoneExt":10,"email":24},"Alessandro Petrecca, MD","alessandro.petrecca@guest.policlinicogemelli.it",[26],{"facility":27,"status":10,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"UOC di Ostetricia e Patologia Ostetrica","Rome","Lazio","00168","Italy","IT",{"type":34,"coordinates":35},"Point",[36,37],12.51133,41.89193,{"lat":37,"lon":36},[40,44,46,47,49,51,53,55,57],{"name":41,"role":19,"phone":42,"phoneExt":10,"email":43},"Concetta Cesare","+390630158531","att@policlinicogemelli.it",{"name":18,"role":45,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":23,"role":45,"phone":10,"phoneExt":10,"email":10},{"name":48,"role":45,"phone":10,"phoneExt":10,"email":10},"Beatrice Valentini, MD",{"name":50,"role":45,"phone":10,"phoneExt":10,"email":10},"Roberta Rullo, MD",{"name":52,"role":45,"phone":10,"phoneExt":10,"email":10},"Alice Dal Miglio, MD",{"name":54,"role":45,"phone":10,"phoneExt":10,"email":10},"Federico Quintiliani, MD",{"name":56,"role":45,"phone":10,"phoneExt":10,"email":10},"Marta Vicidomini, MD",{"name":58,"role":45,"phone":10,"phoneExt":10,"email":10},"Tullio Ghi, MD, PhD",{"type":60,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100643292","evaluation-of-neonatal-acute-hypoxia-at-delivery-using-fetal-physiology-and-eucapnic-ph-assessment-100643292",false,"NCT07629271","Evaluation of Neonatal Acute Hypoxia at Delivery Using Fetal Physiology and Eucapnic pH Assessment","Neonatal Outcomes After Acute Hypoxia: Re-evaluating Cardiotocography Traces Using Fetal Physiology-Based Interpretation and Eucapnic pH Assessment","NOAH","Inclusion Criteria:\n\n* Singleton pregnancies\n* Term neonates (gestational age =or\\> 37 weeks)\n* Availability of clinical data, such as\n\n  * CTG tracing within 90 minutes before delivery\n  * Umbilical cord blood gas analysis (arterial sample)\n* Signed informed consent (only for the prospective arm)\n\nExclusion Criteria:\n\n* Major fetal anomalies\n* Incomplete or missing CTG or blood gas data\n* Elective cesarean sections without labor","FEMALE","18 Years",{"count":72,"type":73},1000,"ESTIMATED","1 Day","OBSERVATIONAL","This study aims to improve understanding of how fetuses respond to oxygen deprivation during labor by re-evaluating cardiotocography (CTG) recordings using a physiology-based interpretation approach and comparing these findings with umbilical cord blood gas measurements at birth, including eucapnic pH assessment.\n\nThe study will include term pregnancies and combines retrospective data analysis with prospective enrollment. Researchers will investigate whether physiology-based CTG interpretation can better identify signs of fetal compromise and whether eucapnic pH may improve the distinction between respiratory and metabolic acidosis. Findings may contribute to improving fetal monitoring strategies and the assessment of newborn condition at birth.",[78],"Neonatal Acidemia and Hypoxia",[80,81,82,83],"cardiotocography","eucapnic pH","neonatal hypoxia","labor and delivery","NOT_YET_RECRUITING","2026-06-05",{"date":87,"type":88},"2026-06-09","ACTUAL",{"date":90,"type":73},"2026-06",{"date":92,"type":73},"2028-12",{"name":5,"class":6},1]