[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580244":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":22,"centralContacts":26,"locations":10,"responsibleParty":32,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":10,"eligibilityCriteria":42,"healthyVolunteers":38,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":10,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":61,"leadSponsor":63,"locationsCount":10},{"fullName":5,"class":6},"Ankara City Hospital Bilkent","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"cohort A: statin-use",null,[12],"Diagnostic Test: TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.",{"label":14,"type":10,"description":10,"interventionNames":15},"Cohort B: statin-nonuse",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","TOF (Train-of-Four) monitoring for depth of neuromuscular blockade.","General anesthesia with propofol and fentanyl induction followed by rocuronium for neuromuscular blockade; maintenance with desflurane and remifentanil.",[14,9],[23],{"name":24,"affiliation":5,"role":25},"Emine Emen, ass. Dr.","STUDY_CHAIR",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"ismail aytaç, assoc. Prof. Dr","CONTACT","+905056340369","aytacismail1972@gmail.com",{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","ismail aytaç","Ass. Prof. Dr.","100580244","evaluation-of-neuromuscular-blockade-responses-in-statin-using-and-non-using-patients-100580244",false,"NCT06834776","Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients","Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients Undergoing Elective Surgery Under General Anesthesia, Monitored by Train-of-Four (TOF)","Inclusion Criteria:\n\n* Age 18-75 years\n* ASA classification I, II, III\n* BMI 18-30\n* Statin use for at least 3 months or no prior statin use\n* Elective surgery requiring general anesthesia with endotracheal intubation\n* Signed informed consent for participation in the study\n\nExclusion Criteria:\n\n* ASA classification IV or higher\n* BMI \\\u003C18 or \\>30\n* History of liver or renal insufficiency (creatinine \\>1.6, liver function tests \\>2x normal)\n* Neuromuscular, psychiatric, or neurological disorders\n* Pregnancy\n* Use of drugs affecting neuromuscular function (e.g., anticonvulsants, aminoglycosides)\n* History of malignant hyperthermia\n* Respiratory disorders, including sleep apnea\n* Allergy to anesthetic drugs used in the study","ALL","18 Years","75 Years",{"count":47,"type":48},104,"ESTIMATED","OBSERVATIONAL","This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins. The study will assess the depth of neuromuscular blockade, recovery time, and postoperative residual curarization using Train-of-Four (TOF) monitoring, with the primary goal of determining whether statin use alters the neuromuscular blockade management.",[52,53,54],"Neuromuscular Blockade","Statin-Associated Myopathy","Neuromuscular Monitoring","NOT_YET_RECRUITING","2025-02-15",{"date":58,"type":59},"2025-02-19","ACTUAL",{"date":56,"type":48},{"date":62,"type":48},"2025-12-15",{"name":5,"class":6}]