[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100343562":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":45,"centralContacts":50,"locations":56,"responsibleParty":76,"collaborators":80,"id":84,"slug":85,"hasResults":86,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":35,"eligibilityCriteria":89,"healthyVolunteers":86,"sex":90,"minAge":91,"maxAge":35,"enrollmentInfo":92,"targetDuration":35,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":35,"overallStatus":58,"whyStopped":35,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of Heidelberg Medical Center","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Transbond XT","ACTIVE_COMPARATOR","Application of different orthodontic surface sealants to participants:\n\nRandomly assigned quadrants in this arm will receive a bonding primer (Transbond XT) The investigators will evaluate in this arm\n\n1. the development of demineralization\n2. its adverse effects after application",[13],"Device: Transbond XT",{"label":15,"type":16,"description":17,"interventionNames":18},"Protecto®CaF2Nano","EXPERIMENTAL","Application of different orthodontic surface sealants to participants:\n\nRandomly assigned quadrants in this arm will receive an orthodontic surface sealant (Protecto®CaF2Nano).\n\nThe investigators will evaluate in this arm\n\n1. its abrasion behavior and the development of demineralization\n2. its adverse effects after the application",[19],"Device: Protecto®CaF2Nano",{"label":21,"type":16,"description":22,"interventionNames":23},"Pro Seal®","Application of different orthodontic surface sealants to participants:\n\nRandomly assigned quadrants in this arm will receive an orthodontic surface sealant (Pro Seal®).\n\nThe investigators will evaluate in this arm\n\n1. its abrasion behavior and the development of demineralization\n2. its adverse effects after the application",[24],"Device: Pro Seal®",{"label":26,"type":16,"description":27,"interventionNames":28},"Opal® Seal","Application of different orthodontic surface sealants to participants:\n\nRandomly assigned quadrants in this arm will receive an orthodontic surface sealant (Opal®Seal).\n\nThe investigators will evaluate in this arm\n\n1. its abrasion behavior and the development of demineralization\n2. its adverse effects after the application",[29],"Device: Opal®Seal",[31,36,39,41],{"type":32,"name":9,"description":33,"armGroupLabels":34,"otherNames":35},"DEVICE","Application of\n\n• Transbond XT (activator comparator) to labial surfaces of teeth of randomized quadrants.",[9],null,{"type":32,"name":15,"description":37,"armGroupLabels":38,"otherNames":35},"Application of\n\n• Protecto®CaF2Nano (orthodontic surface sealant) to labial surfaces of teeth of randomized quadrants.",[15],{"type":32,"name":21,"description":37,"armGroupLabels":40,"otherNames":35},[21],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":35},"Opal®Seal","Application of\n\n• Opal®Seal (orthodontic surface sealant) to labial surfaces of teeth of randomized quadrants.",[26],[46],{"name":47,"affiliation":48,"role":49},"Sinan Sen, Dr.","Department of Orthodontics and Dentofacial Orthopaedics, University of Heidelberg","STUDY_DIRECTOR",[51],{"name":47,"role":52,"phone":53,"phoneExt":54,"email":55},"CONTACT","0049622156","6583","sinan.sen@med.uni-heidelberg.de",[57],{"facility":48,"status":58,"city":59,"state":35,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"RECRUITING","Heidelberg","69120","Germany","DE",{"type":64,"coordinates":65},"Point",[66,67],8.69079,49.40768,{"lat":67,"lon":66},[70,71],{"name":47,"role":52,"phone":53,"phoneExt":54,"email":55},{"name":72,"role":52,"phone":73,"phoneExt":74,"email":75},"Sebastian Zingler, Dr.","004956","36565","sebastian.zingler@med.uni-heidelberg.de",{"type":77,"investigatorFullName":78,"investigatorTitle":79,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Sinan Sen","Senior Teaching and Research Assistant",[81],{"name":82,"class":83},"Heidelberg Engineering GmbH","INDUSTRY","100343562","evaluation-of-optical-coherence-tomography-in-dentistry-100343562",false,"NCT03753256","Evaluation of Optical Coherence Tomography in Dentistry","Inclusion Criteria:\n\n* Orthodontic treatment need\n* Informed consent from all patients and their parents or legal guardians after explaining of the study\n\nExclusion Criteria:\n\n• withdrawn consent","ALL","6 Years",{"count":93,"type":94},20,"ESTIMATED","INTERVENTIONAL",[97],"NA","Optical coherence tomography (OCT) is a medical diagnostic tool, providing non-invasive, non-radiative and high resolution imaging. OCT has been established since many years in ophthalmology. In dentistry the diagnostic potential of OCT is currently increasingly being noticed. This clinical study includes two individual trials: (i) Longitudinal assessment of surface sealant thickness using optical coherence tomography and (ii) comparison of crevicular fluid levels of inflammatory cytokines after the application of surface sealants.",[100,101],"Dental Caries","Tooth Demineralization","2018-11-26",{"date":104,"type":105},"2018-11-28","ACTUAL",{"date":107,"type":105},"2017-12-04",{"date":109,"type":94},"2027-12",{"name":5,"class":6},1]