[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615989":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":10,"responsibleParty":26,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":34,"acronym":35,"eligibilityCriteria":36,"healthyVolunteers":32,"sex":37,"minAge":38,"maxAge":10,"enrollmentInfo":39,"targetDuration":10,"studyType":42,"phases":10,"briefSummary":43,"conditions":44,"keywords":48,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":10},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"preeclamptic women > 22 weeks",null,"All eligible patients meeting inclusion criteria during the study period will be enrolled, as no sample-size calculation is feasible due to the absence of prior literature.\n\nInclusion Criteria Pregnancies complicated by preeclampsia or gestational hypertension ≥22 weeks Age ≥18 years Signed informed consent Exclusion Criteria Intrauterine fetal demise Major fetal anomalies or chromosomal abnormalities Maternal cardiac disease or ongoing cardiologic therapy Chronic kidney disease Twin or multiple pregnancies Pregestational diabetes Study Procedures\n\nAt enrollment and near delivery, all patients will undergo:\n\nNon-invasive hemodynamic assessment (USCOM-1A): HR, SV, CO, TVR, inotropy index, PKR, systolic and diastolic blood pressure.\n\nMaternal blood testing for sFlt-1\u002FPlGF ratio. Uterine artery Doppler: systolic peak and pulsatility index. Ophthalmic artery Doppler and ONSD measurement: performed bilaterally in supine position; PSV peaks and PSV ratio calculated.\n\nCarotid Doppler (CFTI): meas",[13],"Diagnostic Test: Doppler evaluation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Doppler evaluation","Non-invasive hemodynamic assessment (USCOM-1A): HR, SV, CO, TVR, inotropy index, PKR, systolic and diastolic blood pressure.\n\nMaternal blood testing for sFlt-1\u002FPlGF ratio. Uterine artery Doppler: systolic peak and pulsatility index. Ophthalmic artery Doppler and ONSD measurement: performed bilaterally in supine position; PSV peaks and PSV ratio calculated.\n\nCarotid Doppler (CFTI): measured at baseline and after PLR; ΔCFTI of 10-15% considered indicative of fluid responsiveness.\n\nLung ultrasound POCUS: evaluation of 8 thoracic zones using a curvilinear probe; ≥3 B-lines bilaterally considered positive for interstitial edema.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Elvira Di Pasquo, Medical Doctor","CONTACT","003906301555589","elvira.dipasquo@policlinicogemelli.it",{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Di Pasquo Elvira","Medical Doctor","100615989","evaluation-of-patients-with-hypertensive-disorders-of-pregnancy-an-ambispective-observational-study-100615989",false,"NCT07299773","Evaluation of Patients With Hypertensive Disorders of Pregnancy: An Ambispective Observational Study","PREP","Inclusion Criteria:\n\n* Pregnancies complicated by preeclampsia or gestational hypertension ≥22 weeks\n* Age ≥18 years\n* Signed informed consent\n\nExclusion Criteria:\n\n* intrauterine fetal demise\n* Major fetal anomalies or chromosomal abnormalities\n* Maternal cardiac disease or ongoing cardiologic therapy\n* Chronic kidney disease\n* Twin or multiple pregnancies\n* Pregestational diabetes","FEMALE","18 Years",{"count":40,"type":41},120,"ESTIMATED","OBSERVATIONAL","The overall objective of this study is to evaluate the prognostic role of ultrasound and laboratory parameters, specifically their potential ability to predict severe forms of preeclampsia and adverse maternal-fetal outcomes.\n\nIn particular, the aim of the present research is to obtain data on the prognostic value of ultrasonographic and biochemical parameters in patients with hypertensive disorders of pregnancy.",[45,46,47],"Preeclampsia","Preeclampsia (PE)","Hypertensive Disorder of Pregnancy",[49,50,51],"preeclampsia","ophtalmic nerve","ophtalmic artery","NOT_YET_RECRUITING","2025-12-17",{"date":55,"type":56},"2025-12-23","ACTUAL",{"date":58,"type":41},"2026-01-01",{"date":60,"type":41},"2027-12-01",{"name":5,"class":6}]