[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628591":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":39,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":50,"maxAge":10,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Adults with Cushing's disease evaluated for pituitary surgery",null,"Adults (≥18 years) with biochemically confirmed Cushing's disease with negative or doubtlful or microadenoma on pituitary MRI and are discussed for surgical management; who benefited from a\\[18F\\]FET PET in their clinical work-up.",[13],"Other: Data-only evaluation of [18F]FET PET, pituitary MRI, and biomarkers",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"Data-only evaluation of [18F]FET PET, pituitary MRI, and biomarkers","No study-specific procedures. The study evaluates existing \\[18F\\]FET PET imaging pituitary MRI, and routine biochemical markers collected as part of standard care.",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Anthime FLAUS, MD","CONTACT","+33 4 72 35 69 99","anthime.flaus@chu-lyon.fr",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":10},"Hôpital Louis Pradel - Service de Médecine Nucléaire","RECRUITING","Bron","69500","France","FR",{"type":34,"coordinates":35},"Point",[36,37],4.91303,45.73865,{"lat":37,"lon":36},{"type":40,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100628591","evaluation-of-positron-emission-tomography-pet-with-18ffet-for-the-detection-of-acth-secreting-corticotroph-pituitary-neuroendocrine-tumors-100628591",false,"NCT07463625","Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors.","Evaluation of [18F]FET PET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors","PiTFET","Inclusion Criteria:\n\n* Adults (≥18 years).\n* Biochemical diagnosis of Cushing's disease as part of initial management.\n* Pituitary MRI performed; if visible, microadenoma \\\u003C10 mm in diameter.\n* Indication for discussion in multidisciplinary tumor board for surgical management.\n\nExclusion Criteria:\n\n* Minor (age \\\u003C18 years).\n* Macroadenoma of the pituitary.\n* ACTH-dependent hypercortisolism secondary to ectopic secretion.","ALL","18 Years",{"count":52,"type":53},20,"ESTIMATED","OBSERVATIONAL","Cushing's disease results from adrenocorticotropic hormone (ACTH) secretion by corticotroph pituitary neuroendocrine tumors (PitNETs). Magnetic resonance imaging (MRI) is the reference modality for etiological diagnosis but may to visualize small corticotroph microadenomas in up to 30% of the cases, and false positives may occur.\n\nThe study hypothesis is that positron emission tomography (PET) using \\[18F\\]fluoroethyl-L-tyrosine (\\[18F\\]FET) improves localization of ACTH-secreting corticotroph microadenomas compared with MRI and could inform surgical planning and reduce reliance on invasive inferior petrosal sinus sampling.\n\nThis observational cohort (retrospective and prospective data) will assess the diagnostic performance of \\[18F\\]FET PET for tumor localization using postoperative histopathology as the gold standard.\n\nSecondary aims include:\n\n1. assessing cases in which PET modifies localization relative to MRI and is correct by gold standard;\n2. inter-reader agreement between two nuclear medicine physicians;\n3. correlations between PET signal and biochemical markers of hypercortisolism\n4. uni- and multivariable analyses of clinical and imaging parameters influencing PET results;\n5. association between PET findings and subsequent biological remission.",[57,58],"Cushing Disease","ACTH-producing Pituitary Tumour",[60,61,62,63,64,65,66,67,68],"PET","Cushing disease","[18F]FET","PitNET","Corticotroph adenoma","ACTH","Pituitary","MRI","Amino-acid","2026-03-10",{"date":71,"type":72},"2026-03-11","ACTUAL",{"date":74,"type":72},"2023-11-23",{"date":76,"type":53},"2028-11-23",{"name":5,"class":6},1]