[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640843":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":35,"responsibleParty":52,"collaborators":18,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":18,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":18,"enrollmentInfo":63,"targetDuration":18,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":74,"whyStopped":18,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Islamabad Medical and Dental College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Group","EXPERIMENTAL","In the cryotherapy group, following completion of biomechanical preparation, the root canals will be irrigated with 20ml of 0.9% physiological saline solution at a temperature of 1.5-2.5°C for 5 min",[13],"Drug: Saline 0.9% (1.5-2.5°C)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","NO_INTERVENTION","In the control group, final irrigation will be performed using 20 mL of 0.9% physiological saline solution at room temperature for 5 min",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DRUG","Saline 0.9% (1.5-2.5°C)","In this study participant are suing 0.9% normal saline but the temperature will be different for both groups .In cryotherapy group participant are using saline at cold temperature1.5-2.5°C",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Aroosa Bakhtawar, BDS","CONTACT","03379248459","bakhtawararoosa@gmail.com",{"name":32,"role":28,"phone":33,"phoneExt":18,"email":34},"Saima Azam, BDS, FCPS","00923005350740","saima.azam@iideas.edu.pk",[36],{"facility":37,"status":18,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Islamabad Dental Hospital","Islamabad","Federal","44000","Pakistan","PK",{"type":44,"coordinates":45},"Point",[46,47],73.04329,33.72148,{"lat":47,"lon":46},[50,51],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},{"name":32,"role":28,"phone":18,"phoneExt":18,"email":18},{"type":53,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100640843","evaluation-of-post-operative-pain-after-using-intracranial-cryotherapy-during-single-visit-rct-100640843",false,"NCT07598188","Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT","Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit Root Canal Treatment in Teeth With Symptomatic Apical Periodontitis","Inclusion Criteria:\n\nIndividual (male\u002Ffemale) with age \\>18 years with symptomatic apical periodontitis in permanent teeth\n\nExclusion Criteria:\n\n1. Teeth with calcified canals or aberrant root anatomy,\n2. Female Pregnant patients\n3. Patients using medications such as analgesics or anti-biotics drugs and\n4. Those who refuse to participate in the study","ALL","18 Years",{"count":64,"type":65},60,"ESTIMATED","INTERVENTIONAL",[68],"NA","A total of 60 patients presenting with single-rooted teeth exhibiting symptomatic apical periodontitis were subjected to a randomized allocation into two groups of 30 each. Irrigation was done using 3% sodium hypochlorite for 5 seconds in all 60 teeth. Group 1 underwent final irrigation utilizing normal saline at room temperature. Group 2 received final irrigation using normal saline refrigerated between 2-5°C. Pain levels were assessed and recorded before the procedure and at 24 and 48-hour time intervals.",[71],"Periapical Diseases",[73],"Cold therapy, Saline solution, periapical diseases, sodium hypochlorite","NOT_YET_RECRUITING","2026-05-19",{"date":77,"type":78},"2026-05-20","ACTUAL",{"date":80,"type":65},"2026-07-10",{"date":82,"type":65},"2027-03-31",{"name":5,"class":6},1]