[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100385524":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":41,"collaborators":7,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":7,"eligibilityCriteria":49,"healthyVolunteers":46,"sex":50,"minAge":7,"maxAge":7,"enrollmentInfo":51,"targetDuration":7,"studyType":54,"phases":7,"briefSummary":55,"conditions":56,"keywords":7,"overallStatus":27,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"Boston Children's Hospital","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Discarded blood samples","Will utilize the discarded blood from routine clinical blood samples to evaluate the role of immune cells in coagulopathy.",[13],{"name":14,"affiliation":5,"role":15},"Koichi Yuki, MD","PRINCIPAL_INVESTIGATOR",[17,21],{"name":14,"role":18,"phone":19,"phoneExt":7,"email":20},"CONTACT","617-355-6225","koichi.yuki@childrens.harvard.edu",{"name":22,"role":18,"phone":23,"phoneExt":7,"email":24},"Rachel Bernier","857-218-5348","Rachel.Bernier@childrens.harvard.edu",[26],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-71.05977,42.35843,{"lat":37,"lon":36},[40],{"name":14,"role":18,"phone":19,"phoneExt":7,"email":20},{"type":15,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Koichi Yuki","Cardiac Anesthesiologist","100385524","evaluation-of-pro-inflammatory-leukocyte-activity-in-patients-undergoing-cardiac-surgery-100385524",false,"NCT04299828","Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery","Inclusion Criteria:\n\n* Patients (all ages) undergoing complex cardiac surgical procedures with CPB.\n\nExclusion Criteria:\n\n* undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent\n* patient in a moribund condition American Society of Anesthesiology (ASA 5) -patient with a hematological and\u002For oncological disease\n* Jehovah witnesses.","ALL",{"count":52,"type":53},100,"ESTIMATED","OBSERVATIONAL","The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to:\n\n1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels\n2. Understand the correlation between GABA and inflammatory cytokines (and\u002For activated monocytes) and\n3. Assess the correlation between thrombosis and monocyte activation in patients undergoing cardiac surgery under CPB and at risk of thrombosis.",[57,58],"Congenital Heart Disease","Coagulation","2026-01-05",{"date":61,"type":62},"2026-01-07","ACTUAL",{"date":64,"type":62},"2022-05-31",{"date":66,"type":53},"2026-12",{"name":5,"class":6},1]