[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613171":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":22,"locations":23,"responsibleParty":43,"collaborators":45,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":22,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":26,"whyStopped":22,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Nantes University Hospital","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Exposed group (periodontitis)","Patients diagnosed with generalized stage 3 or 4 periodontitis (Chicago 2017 Classification).",[12],"Other: Periodontal examination and pulse wave velocity",{"label":14,"type":6,"description":15,"interventionNames":16},"Non-exposed group (healthy control)","Patients with a healthy periodontium and no history of periodontal disease.",[12],[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"Periodontal examination and pulse wave velocity","Clinical oral examination (plaque index, bleeding on probing, probing depth, clinical attachment loss), lipid profile measurement, anthropometric and hemodynamic assessments (BMI, blood pressure, pulse wave velocity).",[9,14],null,[24],{"facility":25,"status":26,"city":27,"state":22,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"CHU de Nantes","RECRUITING","Nantes","44093","France","FR",{"type":32,"coordinates":33},"Point",[34,35],-1.55336,47.21725,{"lat":35,"lon":34},[38],{"name":39,"role":40,"phone":41,"phoneExt":22,"email":42},"Camille BECHINA","CONTACT","0240083333","camille.bechina@chu-nantes.fr",{"type":44,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[46,48,50],{"name":47,"class":6},"French Interregional Group of Clinical Research and Innovation",{"name":49,"class":6},"Université de Nantes",{"name":51,"class":52},"Axelife company","UNKNOWN","100613171","evaluation-of-the-association-between-the-effects-of-generalized-stage-3-and-4-periodontitis-on-arterial-stiffness-and-cardiovascular-risk-the-parocar-study-100613171",false,"NCT07263113","Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study","PAROCAR","Inclusion Criteria:\n\n* Age 40-69 years\n* Minimum of 12 teeth (3 per quadrant)\n* Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium\n\nExclusion Criteria:\n\n* Patients diagnosed with diabetes,\n* Patients diagnosed with hypertension or with a history of severe cardiovascular disease,\n* Patients diagnosed with familial hypercholesterolaemia,\n* Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results,\n* Patients with a BMI ≥ 30 kg\u002Fm²,\n* Patients who have previously undergone periodontal treatment,\n* Patients who consume more than 2 units of alcohol per day,\n* Patients who refuse to participate in the study,\n* Minors and patients under the age of 40,\n* Adult patients under legal protection (guardianship, curatorship),\n* Patients deprived of their liberty,\n* Pregnant or breastfeeding women,\n* Patients not affiliated with a health insurance scheme (AME)\n* Patients already included in another interventional study",true,"ALL","40 Years","69 Years",{"count":65,"type":66},206,"ESTIMATED","INTERVENTIONAL",[69],"NA","Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways.\n\nThe PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.",[72,73],"Periodontis","Atherosclerosis Cardiovascular Disease",[75,76,77,78],"periodontis","Atherosclerosis","Cardiovascular Risk","Arterial Stiffness","2026-06-22",{"date":81,"type":82},"2026-06-23","ACTUAL",{"date":84,"type":82},"2026-04-10",{"date":86,"type":66},"2027-12-01",{"name":5,"class":6},1]