[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581580":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":32,"responsibleParty":48,"collaborators":19,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":19,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":19,"enrollmentInfo":59,"targetDuration":19,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":71,"whyStopped":19,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Patients diagnosed with precancerous lesions of the cervix CIN\u002FSIL","Patients diagnosed with precancerous lesions of the cervix CIN\u002FSIL undergoing diagnostic biopsy\u002Futerine conization since January 2000",[12],"Diagnostic Test: Tissue, diagnostic and prognostic accuracy",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DIAGNOSTIC_TEST","Tissue, diagnostic and prognostic accuracy","The clinical data and histological samples of patients with a diagnosis of CIN\u002FSIL on cervical biopsies or conization (performed as required by the normal procedure) will be consecutively acquired from all those taken at the Operative Unit of Gynaecology and Physiopathology of Human Reproduction starting from January 2000 and stored at the Operative Unit of Pathological Anatomy and Histology.\n\nSamples fixed in neutral buffered formalin and paraffin added at 50°C will be analysed by repeating histological examination and performing immunohistochemistry for BAG3. All analyses will be performed blinded to the clinical data of the patients and the results of the original examinations. No patients will be examined ex novo, as only paraffin-embedded tissue samples obtained at the time of the initial diagnosis will be analysed.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Paolo Casadio, MD","PRINCIPAL_INVESTIGATOR",[25,29],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","+390512144411","paolo.casadio@aosp.bo.it",{"name":30,"role":26,"phone":19,"phoneExt":19,"email":31},"Giulia Borghese, MD","giulia.borghese@aosp.bo.it",[33],{"facility":5,"status":19,"city":34,"state":19,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Bologna","40138","Italy","IT",{"type":39,"coordinates":40},"Point",[41,42],11.33875,44.49381,{"lat":42,"lon":41},[45,46,47],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},{"name":30,"role":26,"phone":19,"phoneExt":19,"email":31},{"name":22,"role":23,"phone":19,"phoneExt":19,"email":19},{"type":49,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100581580","evaluation-of-the-diagnostic-and-prognostic-value-of-immunohistochemical-markers-in-precancerous-lesions-of-the-cervix-100581580",false,"NCT06852157","Evaluation of the Diagnostic and Prognostic Value of Immunohistochemical Markers in Precancerous Lesions of the Cervix","Evaluation Of The Diagnostic And Prognostic Value Of Immunohistochemical Markers In Precancerous Lesions Of The Cervix","Inclusion Criteria:\n\n* Patients with a diagnosis of CIN\u002FSIL undergoing cervical biopsy\u002Fconcussion whose tissue sample is archived at the Operative Unit of Pathological Anatomy and Histology\n* Obtaining written informed consent for the use of biological samples\n* Patients aged 18 years and over\n\nExclusion Criteria: none","FEMALE","18 Years",{"count":60,"type":61},100,"ESTIMATED","INTERVENTIONAL",[64],"NA","The study aims to evaluate the expression of certain proteins and their diagnostic and prognostic value in precancerous lesions of the cervix.",[67],"Cervix Cancer",[69,70],"cervix cancer","gynaecology","NOT_YET_RECRUITING","2025-02-26",{"date":74,"type":75},"2025-02-28","ACTUAL",{"date":77,"type":61},"2025-02",{"date":79,"type":61},"2026-02",{"name":5,"class":6},1]