[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619416":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":18,"responsibleParty":34,"collaborators":36,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":18,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":63,"whyStopped":18,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":18},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients taking Pervistop","EXPERIMENTAL","24 couples in which both partners will be treated with a combination of EGCG (200 mg), vitamin B12 (1 mg), hyaluronic acid (50 mg), and folic acid (400 µg), administered orally as one tablet once daily for 6 months.",[13],"Dietary Supplement: Pervistop",{"label":15,"type":16,"description":17,"interventionNames":18},"Patients NO taking Pervistop","NO_INTERVENTION","24 couples who will not receive any supplementation",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIETARY_SUPPLEMENT","Pervistop","combination of EGCG, vitamin B12, hyaluronic acid, and folic acid.",[9],[26],{"name":27,"affiliation":5,"role":28},"Domenico Milardi","PRINCIPAL_INVESTIGATOR",[30],{"name":27,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","3394826008","domenico.milardi@policlinicogemelli.it",{"type":35,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[37],{"name":38,"class":39},"Lo.Li.Pharma s.r.l","INDUSTRY","100619416","evaluation-of-the-effect-of-a-dietary-supplement-based-on-egcg-vitamin-b12-hyaluronic-acid-and-folic-acid-on-the-maintenance-of-physiological-balance-and-the-natural-defenses-of-the-male-genital-system-in-subjects-exposed-to-hpv-infection-100619416",false,"NCT07344337","Evaluation of the Effect of a Dietary Supplement Based on EGCG, Vitamin B12, Hyaluronic Acid, and Folic Acid on the Maintenance of Physiological Balance and the Natural Defenses of the Male Genital System in Subjects Exposed to HPV Infection.","PERVI-I","Inclusion Criteria:\n\n* Signed informed consent\n* Couple seeking pregnancy\n* Male partner aged 25-65 years\n* HPV DNA test indicating active HPV infection in the male partner\n* HPV DNA test indicating negativity for HPV infection in the female partner\n\nExclusion Criteria:\n\n* Concomitant diseases causing immunosuppression\n* Treatment with immunomodulatory therapies\n* Use of EGCG or other green tea extracts","ALL","25 Years","65 Years",{"count":51,"type":52},96,"ESTIMATED","INTERVENTIONAL",[55],"NA","This is a randomized pilot interventional study aimed at evaluating the effect of a dietary supplement containing EGCG, vitamin B12, hyaluronic acid, and folic acid on the maintenance of physiological balance and natural defenses of the male genital tract in subjects exposed to HPV infection and seeking care for infertility at natural procreation centers. The study includes 48 couples (96 participants) recruited at the International Scientific Institute \"Paolo VI\" of the A. Gemelli Policlinico, randomly assigned to two groups: 24 couples in which both partners receive one oral tablet per day of the supplement for 6 months, and 24 control couples receiving no supplementation. In addition to the primary objective, secondary outcomes assess potential support of sperm parameters, reproductive well-being of the couples, maintenance of genital mucosal physiological balance with possible reduction of HPV transmission risk to female partners, and support of physiological balance in the presence of co-infections or alterations of the genital microbiota.",[58,59],"HPV Infection","Infertilities",[61,62],"HPV","INFERTILITY","NOT_YET_RECRUITING","2026-01-07",{"date":66,"type":67},"2026-01-15","ACTUAL",{"date":69,"type":52},"2026-03",{"date":71,"type":52},"2028-03",{"name":5,"class":6}]