[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637000":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":48,"locations":54,"responsibleParty":72,"collaborators":26,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":99,"overallStatus":110,"whyStopped":26,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lidocaine 2% (control group)","ACTIVE_COMPARATOR","Participants in this group will receive a single-session trigger point injection using 2% lidocaine without any additives. The injection will be administered into the identified myofascial trigger points using a standardized technique under aseptic conditions.",[13],"Drug: Lidocaine 2 %",{"label":15,"type":16,"description":17,"interventionNames":18},"Lidocaine + Sodium Bicarbonate (buffered group)","EXPERIMENTAL","Participants in this group will receive a single-session trigger point injection using 2% lidocaine combined with sodium bicarbonate. The buffered solution is intended to reduce injection pain and enhance anesthetic effectiveness.",[19],"Drug: Lidocaine + Sodium Bicarbonate",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Lidocaine 2 %","2% lidocaine (preservative-free, without vasoconstrictor) will be administered via intramuscular injection into the identified trigger points. Approximately 1.8 mL will be injected per point using a sterile 25-27 gauge needle. The injection will be performed using a standardized \"fast-in, fast-out\" (peppering) technique.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Lidocaine + Sodium Bicarbonate","A buffered anesthetic solution will be prepared immediately before injection by mixing 2% lidocaine with 8.4% sodium bicarbonate in a ratio of 9:1 (1.8 mL lidocaine + 0.2 mL sodium bicarbonate per injection point). The solution will be administered via intramuscular injection into trigger points using a sterile 25-27 gauge needle and standardized injection technique.",[15],[32,36,40,42,45],{"name":33,"affiliation":34,"role":35},"Khalid elhayes, professor","cairo university oral and maxillofacial surgery department","STUDY_CHAIR",{"name":37,"affiliation":38,"role":39},"Abdelmoez Mohamed El-Sharkawy, Associate professor","cairo University -oral and maxillofacial surgery department","STUDY_DIRECTOR",{"name":41,"affiliation":34,"role":39},"Adham Yehia Zakaria, Lecturer",{"name":43,"affiliation":44,"role":39},"Eman hassan Elzamarany, lecturer","Department of Neurology and Clinical Physiology Faculty of Medicine, Cairo University",{"name":46,"affiliation":34,"role":47},"ola mohamed Abdelfath","PRINCIPAL_INVESTIGATOR",[49],{"name":50,"role":51,"phone":52,"phoneExt":26,"email":53},"ola mohamed Abdelfatah, bachelor","CONTACT","+201122789240","ola.abdelfatah@dentistry.cu.edu.eg",[55],{"facility":56,"status":26,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Faculty of Dentistry Cairo University","Cairo","Cairo Governorate","22023","Egypt","EG",{"type":63,"coordinates":64},"Point",[65,66],31.24967,30.06263,{"lat":66,"lon":65},[69],{"name":70,"role":51,"phone":71,"phoneExt":26,"email":53},"Ola mohamed Abdelfatah","01122789240",{"type":47,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ola mohamed abdelfatah","\"Postgraduate Researcher (Master's Candidate), Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University\"","100637000","evaluation-of-the-effect-of-adding-sodium-bicarbonate-to-lidocaine-in-the-treatment-of-myofascial-pain-syndrome-100637000",false,"NCT07572994","Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome","Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome Using Surface Electromyography (sEMG)","BIC-LIDO-MPS","Inclusion Criteria:\n\nPatients aged 16 to 70 years Clinical diagnosis of myofascial pain syndrome (MPS) Presence of active myofascial trigger points Pain duration ≥ 3 months Pain intensity ≥ 4 on the Visual Analog Scale (VAS) Trigger points located in accessible muscles No trigger point injection in the affected area within the past 3 months Ability and willingness to provide informed consent Willingness to comply with study procedures and follow-up visits\n\nExclusion Criteria:\n\nKnown allergy or hypersensitivity to lidocaine, sodium bicarbonate, or other amide-type local anesthetics Current use of anticoagulants or presence of bleeding disorders Local or systemic infection at or near the injection site History of fibromyalgia, cancer-related pain, or central pain syndromes Major psychiatric disorders (e.g., schizophrenia, severe depression) Recent trauma or surgery to the neck, shoulder, or back within the past 6 months Use of analgesics (e.g., NSAIDs, opioids) within 5 days prior to injection Severe systemic diseases (e.g., uncontrolled diabetes, liver failure, kidney failure, severe cardiovascular disease)\n\n\\-","ALL","16 Years","70 Years",{"count":87,"type":88},30,"ESTIMATED","INTERVENTIONAL",[91],"NA","This study is designed to evaluate a method to improve the treatment of myofascial pain syndrome (MPS), a common condition that causes muscle pain, tenderness, and reduced movement due to the presence of trigger points in muscles.\n\nA commonly used treatment for this condition is the injection of a local anesthetic called lidocaine into these trigger points to relieve pain. However, the pain relief from lidocaine alone may be temporary.\n\nIn this study, we are investigating whether adding a small amount of sodium bicarbonate to lidocaine can improve its effectiveness. Sodium bicarbonate may reduce the pain during injection and help the anesthetic work faster and possibly last longer.\n\nParticipants in this study will be randomly assigned into one of two groups:\n\nOne group will receive lidocaine alone. The other group will receive lidocaine mixed with sodium bicarbonate.\n\nThe injection will be performed once into the painful muscle trigger points under sterile conditions.\n\nPain levels will be assessed using a simple pain scale, and muscle activity will be measured using a non-invasive technique called surface electromyography (sEMG), which records muscle electrical activity. These measurements will be taken before the injection, immediately after, and during follow-up visits.\n\nParticipants may experience mild discomfort during or after the injection, but all procedures are routinely used in clinical practice. Safety measures will be in place to manage any possible side effects.\n\nThe goal of this study is to determine whether the combined injection provides better pain relief, improves muscle function, and enhances patient comfort compared to lidocaine alone.",[94,95,96,97,98],"Myofacial Pain","Myofacial Pain Syndrome","Myofacial Pain Syndromes","Trigger Point Pain, Myofascial","Myofascial Pain Dysfunction Syndrome",[100,101,102,103,104,105,106,107,108,109],"lidocaine","Sodium Bicarbonate","Buffered Lidocaine","Trigger Point Injection","Surface Electromyography","Myofascial Trigger Points","Muscle Pain","Injection Pain","Muscle Activity","Musculoskeletal Pain","NOT_YET_RECRUITING","2026-05-01",{"date":113,"type":114},"2026-05-07","ACTUAL",{"date":111,"type":88},{"date":117,"type":88},"2026-10-01",{"name":5,"class":6},1]