[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602793":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":42,"locations":50,"responsibleParty":69,"collaborators":26,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":26,"eligibilityCriteria":77,"healthyVolunteers":74,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":93,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Mustafa Kemal University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Laser treatment","EXPERIMENTAL","Laser Group: Group with peri-implantitis to receive low-level laser therapy in addition to non-surgical treatment of peri-implantitis)",[13,14],"Device: Low Level Laser Therapy","Procedure: Non-surgical Periodontal Treatment",{"label":16,"type":17,"description":18,"interventionNames":19},"Non-surgical treatment","ACTIVE_COMPARATOR","Control group: Group with peri-implantitis who will undergo non-surgical treatment for peri-implantitis",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Low Level Laser Therapy","Although low-level laser therapy has been applied in cases of periodontitis, there are only a limited number of studies investigating its additional benefits in implants with peri-implantitis. This study aims to contribute to the literature on this subject.\n\nIn addition to surgical periodontal treatment, low-level laser therapy (LLLT) was applied three times (on the same day as the initial treatment, on the third day, and on the seventh day) to the implants in the test group diagnosed with peri-implantitis. The 940 nm indium gallium arsenide phosphor diode laser (Epic Biolase, Irvine, CA, USA) will be applied perpendicular to the periodontal pocket for 20 seconds at a fixed distance of 15 mm and a continuous wavelength (3.41 J\u002Fcm2 application with a 1.76 cm2 spot and 0.3 W average output).",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"PROCEDURE","Non-surgical Periodontal Treatment","Peri-implantitis diagnosis will be made in the control group, and non-surgical periodontal treatment of implants will be performed using titanium curettes (Hu-Friedy, Chicago, IL, USA).",[9,16],[33,36,39],{"name":34,"affiliation":5,"role":35},"Mehmet A Gunenc, DDs","PRINCIPAL_INVESTIGATOR",{"name":37,"affiliation":5,"role":38},"Aysegul Sari, PhD","STUDY_DIRECTOR",{"name":40,"affiliation":5,"role":41},"Osman F Arpag, PhD","STUDY_CHAIR",[43,47],{"name":34,"role":44,"phone":45,"phoneExt":26,"email":46},"CONTACT","+0905076310563","dtmehmetaligunenc@gmail.com",{"name":37,"role":44,"phone":48,"phoneExt":26,"email":49},"05321732518","aysglsr@gmail.com",[51],{"facility":52,"status":26,"city":53,"state":26,"zip":54,"country":55,"countryCode":26,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Hatay Mustafa Kemal University","Hatay","31000","Turkey (Türkiye)",{"type":57,"coordinates":58},"Point",[59,60],27.10486,38.40227,{"lat":60,"lon":59},[63,64,67],{"name":37,"role":44,"phone":48,"phoneExt":26,"email":49},{"name":65,"role":44,"phone":66,"phoneExt":26,"email":46},"Mehmet Ali Gunenc, DDs","+905076310563",{"name":68,"role":35,"phone":26,"phoneExt":26,"email":26},"Mehmet Ali Günenç, DDs",{"type":35,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Aysegul SARI","Associate professor","100602793","evaluation-of-the-effects-of-the-low-level-laser-therapy-as-an-adjunct-to-nonsurgical-treatment-in-patients-with-periimplantitis-100602793",false,"NCT07128134","Evaluation of the Effects of the Low-level Laser Therapy as an Adjunct to Nonsurgical Treatment in Patients With Periimplantitis","Inclusion Criteria:\n\n* The patient must be willing to participate in the study.\n* At least one implant with a pocket depth ≥ 6 mm and radiographic bone loss ≥ 3 mm diagnosed with peri-implantitis.\n* Individuals aged 18-65.\n* Patients who can understand and maintain oral hygiene education.\n\nExclusion Criteria:\n\n* Individuals with any systemic disease that affects periodontal healing (diabetes, cancer, HIV\u002FAIDS, acute infections, liver or kidney dysfunction\u002Finsufficiency, autoimmune disorders: rheumatoid arthritis, systemic lupus erythematosus, Hashimoto's thyroiditis)\n* Female patients who are pregnant or breastfeeding\n* Patients who have undergone periodontal treatment within the last six months\n* Patients who have used antibiotics and regular anti-inflammatory medications within the last six months\n* Use of medications that affect periodontal tissues (cyclosporine, phenytoin, sodium valproate, etc.).","ALL","18 Years","65 Years",{"count":82,"type":83},72,"ESTIMATED","INTERVENTIONAL",[86],"NA","The main objective of this study is to evaluate the clinical efficacy of low-level laser therapy (LLLT) in addition to non-surgical periodontal treatment in patients with peri-implantitis. The study aims to investigate the anti-inflammatory and regenerative effects of low-level laser therapy on peri-implant soft and hard tissues and to reveal its contribution to treatment success.\n\nIn this context, the specific objectives of the study are as follows:\n\n1. To evaluate the effects of LLLT added to non-surgical mechanical treatment on clinical parameters such as plaque index, probing depth, bleeding index, and clinical attachment level.\n2. To examine the contributions of laser therapy to tissue healing by analyzing biochemical markers in peri-implant sulcular fluid over time.",[89],"Periimplantitis",[91,92,16],"Peri-implantitis","Laser therapy","NOT_YET_RECRUITING","2025-08-15",{"date":96,"type":97},"2025-08-17","ACTUAL",{"date":99,"type":83},"2025-08-20",{"date":101,"type":83},"2026-06-30",{"name":5,"class":6},1]