[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617476":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":43,"responsibleParty":64,"collaborators":67,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":26,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":26,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":107,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Leeds Beckett University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Single acute dose (5.6g) of 'Think Tank' Formulation in a caffeine vehicle.","ACTIVE_COMPARATOR","The active formulation will be dissolved in a 200ml volume coffee beverage (1.8g Nescafe, 50-100mg caffeine). The coffee beverage will be brewed at approximately 90-96◦C. When the beverage has reached a temperature of 65◦C the active nutritional formulation will be added and mixed until dissolved. Each acute dose contains, Magnesium 105mg, Sodium 5mg, Creatine Monohydrate 2.5g, Magnesium Gluconate 2g, L-Tyrosine 500mg, Phosphatidylserine 20% powder 200mg, L-Theanine 200mg, Citicoline Sodium 125mg, Rhodiola Rosea Root Extract 100mg.",[13],"Dietary Supplement: Skoshify 'Think Tank' Formulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Single acute dose (2.0g) of matched placebo in a caffeine vehicle.","PLACEBO_COMPARATOR","The placebo will be dissolved in a 200ml volume coffee beverage (1.8g Nescafe, 50-100mg caffeine). The coffee beverage will be brewed at approximately 90-96◦C. When the beverage has reached a temperature of 65◦C the placebo will be added and mixed until dissolved. The placebo contains Maltodextrin from corn 1.5mg and Organic acacia gum powder 0.5g.",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Skoshify 'Think Tank' Formulation","Each acute dose contains, Magnesium 105mg, Sodium 5mg, Creatine Monohydrate 2.5g, Magnesium Gluconate 2g, L-Tyrosine 500mg, Phosphatidylserine 20% powder 200mg, L-Theanine 200mg, Citicoline Sodium 125mg, Rhodiola Rosea Root Extract 100mg.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","The placebo contains Maltodextrin from corn 1.5mg and Organic acacia gum powder 0.5g.",[15],[32],{"name":33,"affiliation":5,"role":34},"Zoe K Kolokotroni, PhD","PRINCIPAL_INVESTIGATOR",[36,40],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","+441138123271","z.kolokotroni@leedsbeckett.ac.uk",{"name":41,"role":37,"phone":26,"phoneExt":26,"email":42},"Lauren J Owen, PhD","l.j.owen@leedsbeckett.ac.uk",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Leeds","West Yorkshire","LS1 3HE","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-1.54785,53.79648,{"lat":55,"lon":54},[58,60,61,62],{"name":33,"role":37,"phone":59,"phoneExt":26,"email":39},"01138123271",{"name":41,"role":37,"phone":26,"phoneExt":26,"email":42},{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":63,"role":34,"phone":26,"phoneExt":26,"email":26},"Therese Fozard, PhD",{"type":34,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Zoe Kolokotroni","Principal Investigator",[68],{"name":69,"class":70},"Sköshify™ Corporate HQ, 7045 Quiet Retreat Court, Niwot, CO 80503-7174","UNKNOWN","100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476",false,"NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.",true,"FEMALE","40 Years","60 Years",{"count":83,"type":84},40,"ESTIMATED","INTERVENTIONAL",[87],"NA","The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106],"Cognitive Assessment","Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Cortisol","Stress","Anxiety","Depression","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity","Effort",[108,109,110,111,112,113,114,115,116],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":119,"type":120},"2026-01-06","ACTUAL",{"date":122,"type":84},"2025-12-15",{"date":124,"type":84},"2026-08-31",{"name":5,"class":6},1]