[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608559":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":48,"collaborators":21,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":21,"enrollmentInfo":60,"targetDuration":21,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":21,"overallStatus":35,"whyStopped":21,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Ramsay Générale de Santé","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patient admitted to intensive care for a high-risk reason of ARI","EXPERIMENTAL","Patient admitted to intensive care for a high-risk reason of ARI : Shock, Sepsis, Cardiovascular arrest, Post-operative unscheduled surgery, Post-operative cardiac surgery",[13,14],"Diagnostic Test: Urine sample","Other: Phone call at day 28",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","Urine sample","5 mL of urine when the patient is admitted in intensive care To look for possible acute renal failure in the patient",[9],null,{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Phone call at day 28","It will allow the following information to be collected:\n\n* Post-resuscitation monitoring and length of hospitalization,\n* Vital status,\n* Collection of adverse events,\n* Concomitant treatments.",[9],[27],{"name":28,"role":29,"phone":30,"phoneExt":21,"email":31},"Matthieu JAMME, Dr","CONTACT","00336 87 64 61 12","mat.jamme@gmail.com",[33],{"facility":34,"status":35,"city":36,"state":21,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Hôpital Privé de l'Ouest Parisien","RECRUITING","Trappes","78190","France","FR",{"type":41,"coordinates":42},"Point",[43,44],2.01781,48.77413,{"lat":44,"lon":43},[47],{"name":28,"role":29,"phone":21,"phoneExt":21,"email":31},{"type":49,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100608559","evaluation-of-the-impact-of-an-alteration-of-nad-metabolism-on-the-renal-prognosis-of-patients-admitted-to-intensive-care-ni-aki-100608559",false,"NCT07203131","Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)","Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care","NI-AKI","Inclusion Criteria:\n\n* Patient, male or female aged over 18,\n* Patient admitted to intensive care for a reason with a high risk of ARI: shock, sepsis, cardio-circulatory arrest, post-operative unscheduled surgery, post-operative cardiac surgery,\n* Patient with normal renal function on admission,\n* Patient affiliated to or beneficiary of a social security scheme,\n* Patient having been informed and having given his\u002Fher free, informed and written consent\n\nExclusion Criteria:\n\n* Minor patient,\n* History of chronic kidney disease,\n* History of kidney transplant,\n* Admission for a reason with a low risk of ARI (neuroresuscitation, voluntary drug intoxication with anxiolytics - antidepressants - psychotropic drugs),\n* Acute non-infectious respiratory failure, (scheduled surgery other than cardiac surgery)\n* Patient hospitalized without consent,\n* Patient in a period of exclusion due to another research still in progress at the time of inclusion,\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision,\n* Pregnant, breastfeeding or parturient woman.","ALL","18 Years",{"count":61,"type":62},150,"ESTIMATED","INTERVENTIONAL",[65],"NA","Among all patients admitted to intensive care, it is estimated that more than half of them are exposed during their stay to acute renal failure (ARF). Impacting the vital prognosis to short term, the occurrence of renal failure is not without consequences in intensive care survivors, presenting an increased risk of death mainly mediated by an excess risk with regard to chronic kidney disease and\u002For certain cardiovascular pathologies.\n\nMalnutrition, particularly vitamin deficiency, has already been reported as a risk factor for AKI. Studies on two models (animal and human) have recently highlighted the importance of NAD+ production failure in the onset of renal failure.\n\nNAD+ synthesis can be done from tryptophan or via a salvage pathway from vitamin PP.\n\nIn a phase 2 study in patients undergoing cardiac surgery, vitamin B3 supplementation was accompanied by a reduction in the occurrence of AKI and a limitation of the duration \u002F intensity of renal dysfunction.\n\nThis innovative research aims to identify an alteration in the metabolic pathway of NAD+ production as a risk factor for AKI in intensive care patients. This would be the first study to address this issue in this specific population.\n\nThe main objective of this research is to describe the association between the urinary Quinolinate\u002FTryptophan ratio on admission and the occurrence of acute renal failure in patients admitted to intensive care unit.",[68,69],"Acute Renal Insufficiency","NAD","2025-09-29",{"date":72,"type":73},"2025-10-02","ACTUAL",{"date":75,"type":73},"2025-03-17",{"date":77,"type":62},"2025-12-05",{"name":5,"class":6},1]