[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100555335":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":25,"locations":31,"responsibleParty":61,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":10,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":10,"enrollmentInfo":74,"targetDuration":77,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Akdeniz University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Postoperative meningitis mortality",null,"Patients with postoperative meningitis and mortality in the intensive care unit.",[13],"Other: CGRP level",{"label":15,"type":10,"description":16,"interventionNames":17},"Postoperative meningitis survival","Patients who developed postoperative meningitis and were discharged from the intensive care unit.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"CGRP level","CGRP and substance P levels will be analysed by ELISA method in CSF and blood materials.",[9,15],[24],"Substans P level",[26],{"name":27,"role":28,"phone":29,"phoneExt":10,"email":30},"Melike Cengiz, MD,Professor","CONTACT","+902422496231","melikecengiz@yahoo.com",[32],{"facility":33,"status":34,"city":35,"state":10,"zip":10,"country":36,"countryCode":10,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Akdeniz University School of Medicine, Department of Anesthesiology and Intensive Care, Turkey","RECRUITING","Antalya","Turkey (Türkiye)",{"type":38,"coordinates":39},"Point",[40,41],30.69556,36.90812,{"lat":41,"lon":40},[44,46,49,52,54,57,59],{"name":45,"role":28,"phone":29,"phoneExt":10,"email":30},"melike cengiz, Professor",{"name":47,"role":28,"phone":29,"phoneExt":10,"email":48},"Ulku Arslan Yildiz, MD","drulkuarslan@gmail.com",{"name":50,"role":51,"phone":10,"phoneExt":10,"email":10},"Oguzhan Arslan, MD","PRINCIPAL_INVESTIGATOR",{"name":53,"role":51,"phone":10,"phoneExt":10,"email":10},"Gul Ozbey, MD",{"name":55,"role":56,"phone":10,"phoneExt":10,"email":10},"Ulku Arslan yildiz, MD","SUB_INVESTIGATOR",{"name":58,"role":56,"phone":10,"phoneExt":10,"email":10},"Sebahat Ozdem, MD",{"name":60,"role":56,"phone":10,"phoneExt":10,"email":10},"Melike Cengiz, MD",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Melike Cengiz","MD,Professor Doctor","100555335","evaluation-of-the-levels-of-calcitonin-gene-related-peptide-and-substance-p-100555335",false,"NCT06510751","Evaluation of the Levels of Calcitonin Gene-related Peptide and Substance P","Evaluation of the Levels of Calcitonin Gene-related Peptide and Substance P in Patients With Post-operative Meningitis","Inclusion Criteria:\n\n* Patients aged 18 years and over\n* Patients followed up in the intensive care unit with suspected meningitis\n\nExclusion Criteria:\n\n* Patients under 18 years of age\n* Patients with suspected meningitis in the intensive care unit who have not undergone neurosurgical operation and do not have CSF drainage catheter","ALL","18 Years",{"count":75,"type":76},51,"ESTIMATED","16 Months","OBSERVATIONAL","In cases of meningitis caused by external ventricular catheters (EVDs), which are the most commonly placed intracranial catheters that can lead to central nervous system infection through contamination\u002Fcolonisation, the diagnosis may not be differentiated by either clinical signs and symptoms or conventional cerebrospinal fluid (CSF) tests. Therefore, due to the limitations in diagnosis and prognostic prediction of EVD-induced meningitis and the high mortality\u002Fmorbidity rates of the disease, markers with high sensitivity and specificity in post-operative meningitis are needed. Calcitonin gene-related peptide (CGRP), a neuropeptide, has been shown to increase when C or Aδ sensory fibres are damaged or in the presence of inflammation in tissues adjacent to the fibres. CGRP is localised in nociceptive nerve terminals together with another neuropeptide, substance P, which has similar biological effects. There are very few studies investigating how CGRP levels in CSF and serum change in bacterial meningitis. Although it is thought that nociception and neuroimmune interactions affect meningeal antibacterial host defence, that nociceptors signal via CGRP to meningeal immune cells during infection, and that this neuroimmune axis exacerbates bacterial meningitis by weakening host defence, it is not yet clear how CGRP and substance P levels affect disease prognosis. This study will evaluate the utility of CGRP and substance P levels as biomarkers to assess diagnosis and treatment response in patients with post-operative meningitis followed in the intensive care unit.",[81,82,83],"Meningitis","Diagnosis","Prognosis",[85,86,87],"Postoperative meningitis","Calcitonin gene-related peptide","Substance P","2024-07-15",{"date":90,"type":91},"2024-07-19","ACTUAL",{"date":93,"type":91},"2024-03-01",{"date":95,"type":76},"2025-08-30",{"name":63,"class":6},1]