[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553015":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":34,"responsibleParty":66,"collaborators":68,"id":73,"slug":10,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":10,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"JAK2 V617F mutation positive MPN patients",null,"Patients with MPN disease with a JAK2 mutation",[13],"Other: Blood Draw",{"label":15,"type":10,"description":16,"interventionNames":17},"CALR-mutation positive patients","Patients with MPN disease with a CALR mutation",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Blood Draw","The amount of blood that will be collected for this is 50 mL(milliliters), or about 3 ½ tablespoons.",[15,9],[24],{"name":25,"affiliation":26,"role":27},"Aleksander Chojecki, MD","Atrium Health Levine Cancer","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Courtney Schepel","CONTACT","(980) 292-0817","Courtney.Schepel@atriumhealth.org",[35,51],{"facility":26,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Charlotte","North Carolina","28204","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-80.84313,35.22709,{"lat":46,"lon":45},[49,50],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":25,"role":27,"phone":10,"phoneExt":10,"email":10},{"facility":52,"status":36,"city":53,"state":38,"zip":54,"country":40,"countryCode":41,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Wake Forest Baptist Comprehensive Cancer Center","Winston-Salem","27157",{"type":43,"coordinates":56},[57,58],-80.24422,36.09986,{"lat":58,"lon":57},[61,65],{"name":62,"role":31,"phone":63,"phoneExt":10,"email":64},"Ruben Mesa, MD","336-716-4618","ruben.mesa@atriumhealth.org",{"name":62,"role":27,"phone":10,"phoneExt":10,"email":10},{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[69,71],{"name":70,"class":6},"Atrium Health Levine Cancer Institute",{"name":72,"class":6},"Brookdale University Hospital Medical Center","100553015",false,"NCT06480591","Evaluation of the Pathobiology of CALR-mutated MPN Cells","Inclusion Criteria:\n\n* Written (or electronic) informed consent and HIPAA authorization for release of personal health information by participant or his\u002Fher legally authorized representative (LAR).\n* Age ≥ 18 years at the time of enrollment\n* Diagnosis of myeloproliferative neoplasm (MPN) according to 2022 World Health Organization classification of MDS\u002FMPNs\n* CALR-positive genetic mutation\n\nExclusion Criteria:\n\n\\- Diagnosis of MPN with JAK2 V617F mutation",true,"ALL","18 Years",{"count":82,"type":83},35,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations.",[87],"Myeloproliferative Neoplasm",[89,90,91],"Thrombosis","JAK2 mutation","CALR mutation","2026-05-21",{"date":94,"type":95},"2026-05-22","ACTUAL",{"date":97,"type":95},"2025-01-21",{"date":99,"type":83},"2026-09",{"name":5,"class":6},2]