[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596226":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":18,"centralContacts":19,"locations":25,"responsibleParty":41,"collaborators":18,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":45,"sex":51,"minAge":52,"maxAge":18,"enrollmentInfo":53,"targetDuration":18,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":66,"whyStopped":18,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"GFR Measurement Using 4-Phase CT Urography and Comparison with Iohexol Clearance","A study with one arm, adding experimental procedures to standard of care (a 4-phase CT urography and biological sampling) in order to evaluate the accuracy of GFR measurement by CT urography in patients with chronic kidney disease.",[12],"Other: Glomerular Filtration Rate measurement with iohexol clearance",[14],{"type":6,"name":15,"description":16,"armGroupLabels":17,"otherNames":18},"Glomerular Filtration Rate measurement with iohexol clearance","After performing a 4-phase CT urography (or 3-phase CT scan, with the addition of a 4th phase for research purposes), performed for clinical indications as part of the patient's care, and using iohexol as a contrast agent, patients will undergo a biological measurement of iohexol clearance, based on serum and urine samples taken over 4 periods of 1 hour, between 3 and 7 hours after the CT scan. No iohexol will be reinjected to measure GFR. The CT scan images will be segmented by the investigator to determine the CT-measured GFR.",[9],null,[20],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},"Thomas STEHLE, Dr","CONTACT","+33145178452","thomas.stehle@aphp.fr",[26],{"facility":27,"status":18,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Assistance Publique Hôpitaux de Paris - CHU Henri Mondor - Créteil","Créteil","Île-de-France Region","94000","France","FR",{"type":34,"coordinates":35},"Point",[36,37],2.46569,48.79266,{"lat":37,"lon":36},[40],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},{"type":42,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100596226","evaluation-of-the-performance-of-glomerular-filtration-rate-measurement-using-ct-urography-in-patients-with-a-gfr-below-60-mlmin173-m-100596226",false,"NCT07042698","Evaluation of the Performance of Glomerular Filtration Rate Measurement Using CT Urography in Patients With a GFR Below 60 mL\u002FMin\u002F1.73 m²","Evaluation of the Performance of Glomerular Filtration Rate Measurement Using CT Urography in Patients With Chronic Kidney Disease","DUSIR","Inclusion Criteria:\n\n* Patients older than 18 years of age\n* Having given written consent to participate in the study\n* Patient referred to the medical imaging department of the Henri Mondor University Hospital for a 3-phase or 4-phase abdominal CT scan\n* With an estimated GFR according to CKD-EPIcreat2009 \\\u003C 60 ml\u002Fmin\u002F1.73m²\n* Hospitalized or outpatient\n* Affiliated with French national health insurance\n\nExclusion Criteria:\n\n* Patients with hip implants, due to artifacts that make quantification of the contrast agent in the bladder unreliable\n* Lack of health insurance\n* Patients under legal protection.","ALL","18 Years",{"count":54,"type":55},70,"ESTIMATED","INTERVENTIONAL",[58],"NA","Glomerular filtration rate (GFR), which is the main biomarker used in clinical practice to assess kidney function, is usually estimated from the serum concentration of endogenous markers such as creatinine and\u002For cystatin C. GFR estimation equations all share the disadvantage of imperfect accuracy due to non-GFR-related determinants of creatinine and cystatin C. When knowing the exact GFR value is necessary for clinical decision-making, measurement by clearance of an exogenous tracer is required. Various tracers are available, some of which are radioactive tracers (99mTc-DTPA and 51Cr-EDTA), while others are iodinated contrast agents (iohexol, iothalamate). GFR measurement procedures are time-consuming and require significant human resources (4 to 5 hours, or even 24 hours for plasma clearances at very low GFR values).Urinary clearance methods may be inaccurate in cases of inadequate voiding. Plasma clearance results may be inaccurate in cases of increased (overestimation) or decreased (underestimation) extracellular volume, low GFR (unless late sampling is performed), or glomerular hyperfiltration. Measuring tracers requires either warm labs for measuring radioactive markers or labs with HPLC (High Performance Liquid Chromatography) chains for iohexol, which are part of an external quality assurance program. The complexity and\u002For length of GFR measurement procedures, their cost, and laboratory constraints explain why measured GFR is underused in routine clinical practice. There is a critical need to develop GFR measurement methods that are simpler to implement, reliable across the entire GFR spectrum, and widely available. We have demonstrated that it is possible to measure GFR using 4-phase CT urography performed as part of the care of living kidney donor candidates (healthy individuals with normal GFR). The examination takes 10 minutes, requires no biological sampling, and is not subject to potential inaccuracies due to sodium overload or poor bladder emptying.",[61,62,63],"Kidney Diseases","Tomography","X-Ray Computed",[65,62,63],"Glomerular Filtration Rate","NOT_YET_RECRUITING","2025-06-25",{"date":69,"type":70},"2025-06-29","ACTUAL",{"date":72,"type":55},"2025-07-15",{"date":74,"type":55},"2027-07-15",{"name":5,"class":6},1]