[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636688":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":31,"centralContacts":31,"locations":32,"responsibleParty":54,"collaborators":56,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":31,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":31,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":35,"whyStopped":31,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"G.Gennimatas General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"DOFA","ACTIVE_COMPARATOR","This arm will receive:\n\nAnesthesia Induction\n\n* 40 mg\u002Fkg Magnesium sulfate in 100 ml N\u002FS infusion\n* 1 mcg\u002Fkg Dexmedetomidine, max total dose 100mcg in 50 ml N\u002FS infusion\n* 0.3 mg\u002Fkg Ketamine\n* 0.2 ml\u002Fkg of the Mulimix regimen in 100 ml N\u002FS infusion as a bolus (The -Mulimix regimen consists of 50mcg dexmedetomidine, 500 mg lidocaine and 50mg ketamine)\n* 2-3mg\u002Fkg Propofol (for introduction )\n* 4 mg Ondansetron\n* 8mg Dexamethasone\n* 0,9-1 mg\u002Fkg Rocuronium\n* 40mg Parecoxib\n\nAnesthesia Maintenance\n\n* 0.2 ml\u002Fkg\u002Fh of the Multimix regimen in 100 ml N\u002FS\n* Desflurane\n* Fentanyl rescue dose (1mcg\u002Fkg)\n\nPostOp Analgesia\n\n* Paracetamol 1gx4\n* Parecoxib 40mg 1x2\n* Tramadol 100mg (For pain, the patient may take a rescue medication as needed)",[13],"Drug: opioid free anesthesia",{"label":15,"type":10,"description":16,"interventionNames":17},"TIVOFA","This arm will receive:\n\nAnesthesia Induction\n\n* 40 mg\u002Fkg Magnesium sulfate in 100 ml N\u002FS infusion\n* 1 mcg\u002Fkg Dexmedetomidine, max total dose 100mcg in 50 ml N\u002FS infusion\n* 0.3 mg\u002Fkg Ketamine\n* 0.2 ml\u002Fkg of the Mulimix regimen in 100 ml N\u002FS infusion as a bolus (The -Mulimix regimen consists of 50mcg dexmedetomidine, 500 mg lidocaine and 50mg ketamine)\n* Propofol Eleveld TCI model Start bolus 3mcg\u002Fml and titrated according to EEG monitoring\n* 4 mg Ondansetron\n* 8mg Dexamethasone\n* 0,9-1 mg\u002Fkg Rocuronium\n* 40mg Parecoxib\n\nAnesthesia Maintenance\n\n* 0.2 ml\u002Fkg\u002Fh of the Multimix regimen in 100 ml N\u002FS\n* Fentanyl rescue dose (1mcg\u002Fkg)\n\nPostOp Analgesia\n\n* Paracetamol 1gx4\n* Parecoxib 40mg 1x2\n* Tramadol 100mg (For pain, the patient may take a rescue medication as needed)",[18],"Drug: Opiod Free Anesthesia with TCI ELEVELD",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","opioid free anesthesia","OFA with Desflurane",[9],[26],"Desflurane",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Opiod Free Anesthesia with TCI ELEVELD","OFA without Desflurane use TCI Eleveld Model",[15],null,[33],{"facility":34,"status":35,"city":36,"state":31,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"General Hospital of Athens G. Gennimatas","RECRUITING","Athens","11527","Greece","GR",{"type":41,"coordinates":42},"Point",[43,44],23.72784,37.98376,{"lat":44,"lon":43},[47,52],{"name":48,"role":49,"phone":50,"phoneExt":31,"email":51},"Panagiotis Chatzistavridis","CONTACT","00306972871556","p.chatzistavridis@gna-gennimatas.gr",{"name":48,"role":53,"phone":31,"phoneExt":31,"email":31},"PRINCIPAL_INVESTIGATOR",{"type":53,"investigatorFullName":48,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"MD, MSC, PHD(c) Resident of Anaesthesiology",[57],{"name":58,"class":6},"National and Kapodistrian University of Athens","100636688","evaluation-of-the-stress-response-in-anesthesia-use-inhalation-anesthetic-desflurane-versus-tiva-for-bariatric-surgery-100636688",false,"NCT07568938","Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery","Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA TCI ELEVELD Model for Bariatric Surgery","Inclusion Criteria:\n\n* Signed Informed Consent\n* ASA II-III\n* Morbid obesity confirmed diagnosis and approval for surgical treatment\n* Laparoscopic sleeve gastrectomy (LSG) or Gastric By pass (R-Y By pass \u002FSASI\u002FSADI AND one anastomosis by pass )\n* Preop respiratrory assessment conducted\n* Adequate organ and bone marrow function\n\nExclusion Criteria:\n\n* Patients declining or withdrawing consent\n* Patients unsuitabe with regards to compliance to treatment, according to the researcher's assessment\n* Bradycardia, AV block, , postural hypotension\n* QTcF\\>470msec\n* Known allergy or hypersensitiity to any of the medications administered\n* Stop-BANG score \\>6\n* Intraoperative administration of more than 8mg of prednisolone or equivalent\n* Patients who have received corticosteroids for durations \\>3 weeks at any point in their lifetime\n* Participation in other clinical trial for experimental product administered post operatively\n* Diagnosis of depression","ALL","18 Years","65 Years",{"count":70,"type":71},70,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer :\n\n-Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane?\n\nParticipants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.",[77,78,79,80],"Opioid Use","Bariatric Surgery Candidate","TCI Eleveld","Obesity",[82,83,84,85,86,87],"Morbid Obesity","Opioid Free Anesthesia","Nociception Level","Analgesia","Bariatric Surgery","Eleveld Model TCI","2026-05-01",{"date":90,"type":91},"2026-05-06","ACTUAL",{"date":93,"type":91},"2024-01-10",{"date":95,"type":71},"2027-05-30",{"name":5,"class":6},1]