[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632757":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":30,"locations":19,"responsibleParty":35,"collaborators":19,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":19,"enrollmentInfo":48,"targetDuration":19,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":60,"overallStatus":68,"whyStopped":19,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":19},{"fullName":5,"class":6},"Cairo University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"CGF Based Sticky Bone intervention group","EXPERIMENTAL","Participants requiring the surgical removal of an impacted lower third molar will undergo a standard odontectomy procedure under local anesthesia. Immediately following the tooth extraction, a prepared autologous Concentrated Growth Factor (CGF) membrane derived from the patient's own blood then its mixed thoroughly with bovine xenograft bone particles formed Sticky Bone is packed into the fresh extraction socket. The site is then sutured. The arm focuses on evaluating the subsequent healing process, specifically monitoring postoperative pain levels during the first week and measuring changes in alveolar bone density via CBCT scans at a three month follow up.",[13],"Other: Concentrated growth factors",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Concentrated growth factors","This is a third-generation autologous blood concentrate prepared using a dedicated centrifugation system. The process creates a fibrin-rich organic matrix from the patient's own blood, CGF membrane is gently compressed using a sterile press to remove excess liquid. The compressed CGF membrane is mixed thoroughly with bovine xenograft bone particles.The mixture becomes cohesive and elastic, forming Sticky Bone, Then it is packed into the fresh extraction socket to enhance healing",[9],null,[21,24,27],{"name":22,"affiliation":5,"role":23},"Fawaz Shaya Alharbi","PRINCIPAL_INVESTIGATOR",{"name":25,"affiliation":5,"role":26},"Khalid Elhayes, professor","STUDY_CHAIR",{"name":28,"affiliation":5,"role":29},"Abdelmoez Mohamed El-Sharkawy, Associate professor","STUDY_DIRECTOR",[31],{"name":22,"role":32,"phone":33,"phoneExt":19,"email":34},"CONTACT","+230155132114","fawaz.alharbi@dentistry.cu.edu.eg",{"type":23,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"fawaz shaya alharbi","Principal Investigator","100632757","evaluation-of-the-use-of-cgf-based-sticky-bone-packed-in-fresh-odontectomy-site-of-impacted-lower-3rd-molars-100632757",false,"NCT07517835","Evaluation of the Use of CGF Based Sticky Bone Packed in Fresh Odontectomy Site of Impacted Lower 3rd Molars","Clinical and Radiographic Evaluation of the Use of CGF Based Sticky Bone Packed in Fresh Odontectomy Site of Impacted Lower 3rd Molars","CGF","Inclusion Criteria:\n\n* Patients aged 18 years or older\n* Both male and female patients\n* Patients requiring odontectomy of an impacted lower third molar\n\nExclusion Criteria:\n\n* Patients who are pre-surgically symptomatic\n* Use of medications that affect bleeding time or bone remodeling\n* Patients with a history of radiotherapy or chemotherapy\n* Patients who are pregnant or lactating\n* Patients using oral contraceptives\n* Patients with acute or chronic infections\n* Patients with any kind of pathology confirmed radiographically","ALL","18 Years",{"count":49,"type":50},10,"ESTIMATED","INTERVENTIONAL",[53],"NA","This clinical study aims to evaluate the effectiveness of Concentrated Growth Factor (CGF)-based sticky bone in enhancing bone healing after surgical removal of impacted mandibular third molars. Surgical extraction of impacted lower third molars is one of the most common procedures in oral and maxillofacial surgery and is often associated with postoperative complications such as pain, swelling, delayed healing, and bone defects within the extraction socket.\n\nCGF is an autologous platelet concentrate derived from the patient's venous blood through a specific centrifugation process. It contains a high concentration of growth factors that play a key role in angiogenesis, tissue regeneration, and bone formation. When combined with particulate bone graft material, CGF forms a cohesive structure known as \"sticky bone,\" which can provide both biological stimulation and structural support for bone regeneration.\n\nIn this study, CGF-based sticky bone will be placed into the fresh extraction socket immediately after surgical removal of the impacted mandibular third molar. Participants will be followed clinically and radiographically over a defined postoperative period. Clinical parameters such as pain intensity, soft tissue healing, and postoperative complications will be assessed, while radiographic analysis will be used to evaluate bone density and bone regeneration within the extraction site.\n\nThe findings of this study may contribute to improving regenerative techniques in oral and maxillofacial surgery and provide evidence regarding the potential benefits of CGF-based sticky bone in enhancing postoperative healing and bone regeneration following third molar extraction.",[56,57,58,59],"Impacted Lower Third Molar","Alveolar Bone Regeneration Following Odontectomy","Postoperative Pain Management in Oral Surgery","Concentrated Growth Factor for Extraction Socket Healing",[61,16,62,44,63,64,65,66,67],"Bone regeneration","Bone density","Surgical extraction","Extraction of lower 3rd molar","Third molar extraction","Postoperative complications","Postoperative pain","NOT_YET_RECRUITING","2026-04-04",{"date":71,"type":72},"2026-04-08","ACTUAL",{"date":74,"type":50},"2026-04-25",{"date":76,"type":50},"2026-10-15",{"name":5,"class":6}]