[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608521":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":60,"collaborators":10,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Hospital Nord","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients suspected of hypovolemia",null,"Patients with suspected hypovolemia who need to be evaluated for fluid responsiveness",[13],"Drug: Fluid bolus administration",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DRUG","Fluid bolus administration","Fluid infusion of 500 mL of a crystalloïd solution is performed for patients with signs of hypovolemia",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Gary DUCLOS, MD, MSc","CONTACT","+33 4919665531","gary.duclos@ap-hm.fr",[27,44],{"facility":28,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Service de réanimation polyvalente - Hopital Nord","RECRUITING","Marseille 15","13015","France","FR",{"type":35,"coordinates":36},"Point",[37,38],5.35386,43.37224,{"lat":38,"lon":37},[41],{"name":42,"role":23,"phone":43,"phoneExt":10,"email":25},"Gary DUCLOS","+33 491965531",{"facility":45,"status":29,"city":46,"state":10,"zip":47,"country":32,"countryCode":33,"cosmosGeoPoint":48,"geoPoint":52,"contacts":53},"Hopital Caremeau Nimes","Nîmes","30029",{"type":35,"coordinates":49},[50,51],4.35788,43.83665,{"lat":51,"lon":50},[54,58],{"name":55,"role":23,"phone":56,"phoneExt":10,"email":57},"Laurent Muller, MD, phD","+33 4 66 68 68 19","laurent.muller@chu-nimes.fr",{"name":55,"role":59,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":61,"investigatorFullName":42,"investigatorTitle":62,"investigatorAffiliation":63,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","MD, MSc","Aix Marseille Université","100608521","evaluation-of-the-variation-of-the-sub-pulmonary-velocity-time-integral-to-predict-fluid-responsiveness-100608521",false,"NCT07202637","Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness","Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness Prospective Observational Study","Inclusion Criteria:\n\n* Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.\n* Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.\n* Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.\n\nExclusion Criteria:\n\n* Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) \\\u003C 30%.\n* Severe right ventricular dysfunction defined by TAPSE \\\u003C 12 mm.\n* Cardiac arrhythmia or atrial fibrillation.\n* Abdominal compartment syndrome.\n* Amputation of one or both lower limbs.\n* Intracranial hypertension.\n* Pregnant women (ruled out by systematic pregnancy test at ICU admission).\n* Minors.","ALL","18 Years",{"count":74,"type":75},205,"ESTIMATED","OBSERVATIONAL","Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.",[79,80],"Fluid Resuscitation","Fluid Responsiveness Predictability",[82,83,84,85],"fluid responsiveness","echocardiography","Passive Leg Raising","Mini Fluid Challenge","2025-09-23",{"date":88,"type":89},"2025-10-02","ACTUAL",{"date":91,"type":89},"2024-11-07",{"date":93,"type":75},"2027-05",{"name":5,"class":6},2]