[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639604":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":14,"responsibleParty":31,"collaborators":7,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":37,"acronym":38,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":7,"studyType":46,"phases":7,"briefSummary":47,"conditions":48,"keywords":50,"overallStatus":17,"whyStopped":7,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},{"fullName":5,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Andrea Boccatonda, MD","CONTACT","+39 0512143265","andrea.boccatonda@aosp.bo.it",[15],{"facility":16,"status":17,"city":18,"state":19,"zip":20,"country":21,"countryCode":22,"cosmosGeoPoint":23,"geoPoint":28,"contacts":29},"IRCCS Policlinico di Sant'Orsola","RECRUITING","Bologna","Emilia-Romagna","40138","Italy","IT",{"type":24,"coordinates":25},"Point",[26,27],11.33875,44.49381,{"lat":27,"lon":26},[30],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},{"type":32,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100639604","evaluation-of-tissue-and-circulating-microrna-profiles-in-patients-with-hepatocellular-carcinoma-subjected-to-thermal-ablation-100639604",false,"NCT07601464","Evaluation of Tissue and Circulating microRNA Profiles in Patients With Hepatocellular Carcinoma Subjected to Thermal Ablation","TERMOMIRNA","Inclusion Criteria:\n\n* Age ≥ 18\n* Diagnosis of hepatocarcinoma confirmed by radiology (LIRADS criteria\u002Ftriphasic diagnostics) or by biopsy.\n* Indication for thermoablation treatment (for radiofrequency) based on the judgment of the hepatologist\u002Fsurgeon.\n* Informed consent signed by the patient.\n\nExclusion Criteria:\n\n* Presence of metastatic liver lesions of other origins.\n* History of liver transplant.\n* Severe, uncorrectable coagulopathy, contraindicating liver biopsy (where necessary) or ablative procedure.\n* Patient refusal to participate in the study or inability to obtain informed consent.\n* Pregnant women.","ALL","18 Years","64 Years",{"count":44,"type":45},150,"ESTIMATED","OBSERVATIONAL","The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation.\n\nIn addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.",[49],"Hepatocarcinoma",[51,52,53,54],"hepatocarcinoma","liver cancer","microRNA","thermoablation","2026-05-15",{"date":57,"type":58},"2026-05-22","ACTUAL",{"date":60,"type":58},"2026-03-26",{"date":62,"type":45},"2028-12-31",{"name":5,"class":6},1]