[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592194":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":35,"centralContacts":44,"locations":50,"responsibleParty":67,"collaborators":71,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":35,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":35,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":53,"whyStopped":35,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Huazhong University of Science and Technology","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Urolithin A Treatment Group","EXPERIMENTAL","Take a intervention capsule (containing 500 mg of Urolithin A) once daily after breakfast for a total of 12 weeks.",[13],"Dietary Supplement: Urolithin A intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Fisetin Treatment Group","Take a intervention capsule (containing 500 mg of Fisetin) once daily after breakfast for a total of 12 weeks.",[18],"Dietary Supplement: Fisetin intervention",{"label":20,"type":10,"description":21,"interventionNames":22},"Combined Urolithin A and Fisetin Treatment Group","Take a intervention capsule (containing 300 mg of Urolithin A + 200 mg of Fisetin) once daily after breakfast for a total of 12 weeks.",[18,13],{"label":24,"type":25,"description":26,"interventionNames":27},"Placebo Control group","PLACEBO_COMPARATOR","Take a placebo capsule (containing 500 mg of corn starch) once daily after breakfast for a total of 12 weeks.",[28],"Dietary Supplement: Placebo",[30,36,40],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DIETARY_SUPPLEMENT","Fisetin intervention","Participants assigned to this intervention take capsules containing a fixed dose of Fisetin daily after breakfast.",[20,15],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"Placebo","Participants assigned to this intervention take a capsule containing 500 mg of corn starch daily after breakfast.",[24],{"type":31,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"Urolithin A intervention","Participants assigned to this intervention take capsules containing a fixed dose of Urolithin A daily after breakfast.",[20,9],[45],{"name":46,"role":47,"phone":48,"phoneExt":35,"email":49},"Hui Xiong","CONTACT","+86 138 7122 6649","xh9613076@163.com",[51],{"facility":52,"status":53,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Wuchang Hospital Affiliated to Wuhan University of Science and Technology","RECRUITING","Wuhan","Hubei","430000","China","CN",{"type":60,"coordinates":61},"Point",[62,63],114.26667,30.58333,{"lat":63,"lon":62},[66],{"name":46,"role":47,"phone":48,"phoneExt":35,"email":49},{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Liangkai Chen","Associate professor",[72,74],{"name":73,"class":6},"Wuhan Wuchang Hospital",{"name":75,"class":76},"Abinopharm, Inc","NETWORK","100592194","evaluation-of-urolithin-a-and-fisetin-on-improving-sleep-and-aging-biomarkers-100592194",false,"NCT06990256","Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers","Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers in Middle-Aged and Older Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 30-75 years;\n* Total score \\> 5 points on the Pittsburgh Sleep Quality Index (PSQI) for sleep quality assessment;\n* Able to use personal mobile devices for WeChat, internet access, and related operations;\n* Informed about the intervention trial and willing to undergo sleep monitoring and other examinations during the study;\n* Commitment to consume coffee, strong tea, or alcohol ≤1 time per week during the trial period;\n\nExclusion Criteria:\n\n* Participation in any clinical trials or dietary\u002Fexercise intervention programs within the past 3 months or concurrently;\n* Diagnosis of major mental disorders or family history thereof, or current use of psychotropic drugs or mood-regulating medications;\n* Experiencing major psychological trauma (e.g., death of a close relative, significant financial loss) personally or within the family in the past 3 months;\n* Severe diseases affecting inflammatory levels and\u002For endocrine components (e.g., severe obesity, uncontrolled diabetes or poorly controlled blood glucose, myocardial infarction, cerebral infarction);\n* Current use of hormonal medications, beta-blockers, steroids, non-steroidal anti-inflammatory drugs (NSAIDs), etc.;\n* Use of medications potentially affecting sleep or aging biomarkers (e.g., melatonin, antidepressants, anxiolytics) within the past 3 months;\n* Plans for relocation or long-term travel within the next 6 months, which may hinder continuous intervention and follow-up.","ALL","30 Years","75 Years",{"count":88,"type":89},80,"ESTIMATED","INTERVENTIONAL",[92],"NA","The goal of this clinical trial is to evaluate the effects of Urolithin A (UA) and Fisetin on improving sleep and aging biomarkers in middle-aged and older adults. The main questions it aims to answer are:\n\nCan UA and Fisetin improve sleep quality in middle-aged and older adults? Do these substances have a positive effect on aging biomarkers, such as inflammation, oxidative stress, and aging-related proteins? Researchers will compare four groups: Placebo group (a look-alike substance that contains no drug), 500 mg UA group, 500 mg Fisetin group and 300 mg UA + 200 mg Fisetin group.\n\nParticipants will:\n\nTake the assigned capsules daily after breakfast for 12 weeks. Attend three clinic visits (baseline \\[Week 0\\], mid-intervention \\[Week 4\\], and post-intervention \\[Week 12\\]) including blood tests, sleep quality assessments (PSQI scale, actigraphy, polysomnography), and analysis of aging biomarkers (DNA methylation, inflammatory cytokines, etc.). Keep a sleep diary, complete a dietary survey, assess mental health, and measure frailty indicators. Provide stool and urine samples at baseline and post-intervention for gut microbiome and metabolite analysis. This trial aims to provide scientific evidence for the development of new nutritional intervention strategies to improve the healthy aging.",[95,96],"Sleep Disorder","Aging",[98,99,95,96],"Urolithin A","Fisetin","2026-01-16",{"date":102,"type":103},"2026-01-21","ACTUAL",{"date":105,"type":103},"2025-09-16",{"date":107,"type":89},"2026-12-30",{"name":5,"class":6},1]