[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552452":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":48,"collaborators":10,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":64,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Symptomatic group",null,"The symptomatic group consisted of patients who were diagnosed with their first ipsilateral ischemic lesions in the carotid territory (anterior circulation) based on head computed tomography (CT) or magnetic resonance imaging (MRI) conducted within the previous 8 weeks.",[13],"Other: Cardiovascular and cerebrovascular diseases",{"label":15,"type":10,"description":16,"interventionNames":10},"Asymptomatic group","The asymptomatic group included patients who showed no intracranial ischemic lesions on head CT\u002FMRI images and exhibited no neurological symptoms.",[18],{"type":6,"name":19,"description":19,"armGroupLabels":20,"otherNames":10},"Cardiovascular and cerebrovascular diseases",[9],[22],{"name":23,"affiliation":5,"role":24},"Rong Wu, Dr","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":10,"email":29},"CONTACT","+021-18917683516","wurong7111@163.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Shanghai General Hospital","RECRUITING","Shanghai","Shanghai Municipality","200080","China","CN",{"type":40,"coordinates":41},"Point",[42,43],121.45806,31.22222,{"lat":43,"lon":42},[46],{"name":23,"role":27,"phone":47,"phoneExt":10,"email":29},"18917683516",{"type":24,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Rong Wu","Principal Investigator","100552452","evaluation-of-vulnerability-of-carotid-plaques-and-prediction-of-cardio-cerebrovascular-event-using-ultrasonic-imaging-100552452",false,"NCT06473272","Evaluation of Vulnerability of Carotid Plaques and Prediction of Cardio-Cerebrovascular Event Using Ultrasonic Imaging","A Multi-center Prospective Cohort Study on the Evaluation of Vulnerability of Carotid Artery Plaques and Prediction of Cardio-Cerebrovascular Event Risk Using Ultrasonic Imaging","Inclusion Criteria:\n\n1. Patients who fully understand the purpose and significance of this experiment, voluntarily participate, and voluntarily sign the informed consent form;\n2. Patients over 40 years old;\n3. Patients with carotid plaque thickness ≥ 1.5 mm on conventional ultrasound, undergoing routine duplex ultrasound, contrast-enhanced ultrasound, ultrasound elastography, and three-dimensional ultrasound imaging.\n\nExclusion Criteria:\n\n1. Patients with severe cardiopulmonary insufficiency; allergy to sulfur hexafluoride; pregnant or lactating women; those with advanced tumors;\n2. Poor quality of ultrasound images;\n3. Patients who have previously undergone carotid artery stenting or endarterectomy on the same side as the carotid plaque.","ALL","40 Years","100 Years",{"count":62,"type":63},600,"ESTIMATED","36 Months","OBSERVATIONAL","This study included patients with carotid artery atherosclerotic plaques to conduct multimodal ultrasound examinations, aiming to establish a plaque vulnerability assessment model based on ultrasonic imaging indicators, clinical history, and laboratory indicators. Based on the occurrence of cardiovascular and cerebrovascular events during the 3-year follow-up period, the correlation between the vulnerability of carotid plaques and the occurrence of cardiovascular and cerebrovascular events was explored. Furthermore, a cardiovascular and cerebrovascular risk prediction model for patients with plaques was established by combining multi-dimensional data indicators such as patients\\' clinical data and ultrasonic multimodal imaging data, forming a risk warning tool suitable for clinical use and providing a reference for risk management in patients with carotid artery plaques.\n\nResearch Objectives：\n\n1. To establish a plaque vulnerability assessment model based on ultrasonic imaging indicators of plaques, clinical indicators of patients, and laboratory indicators.\n2. To establish a cardiovascular and cerebrovascular risk prediction model for patients with carotid plaques by combining clinical indicators of patients and ultrasonic multimodal imaging data.\n3. To screen ultrasonic imaging indicators for predicting cardiovascular and cerebrovascular events.",[68,69,70],"Carotid Plaque","Ischemic Stroke","Cardiovascular Events","2024-12-03",{"date":73,"type":74},"2024-12-06","ACTUAL",{"date":76,"type":74},"2024-07-01",{"date":78,"type":63},"2027-12-31",{"name":5,"class":6},1]