[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570822":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":34,"centralContacts":39,"locations":50,"responsibleParty":69,"collaborators":44,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":44,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":44,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":44,"overallStatus":53,"whyStopped":44,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Aswan University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: (Narrow Band Ultraviolet B)","ACTIVE_COMPARATOR","About 12 patients will expose to 24 sessions of Narrow Band Ultraviolet B (NB-UVB) radiation (initial dose of 130 - 400 mJ \u002F cm2 ) selected according to skin for 3 month.",[13],"Procedure: NB-UVB",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B: (Methotrexate )","About 12 patients will receive Methotrexate tablets (MTX) in dose of (0.3 mg\u002Fkg\u002Fweek) along with folic acid (5 mg\u002Fday) for 3 month.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group C: (Methotrexate and Narrow Band Ultraviolet B)","About 12 patients will undergo the treatment by both Methotrexate tablets (MTX) and Narrow Band Ultraviolet B( NB-UVB) radiation.for 3 month.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Group D (Control Group)","About 12 patients apparently healthy individuals as control group.and will not take any medication",[13],[27],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"PROCEDURE","NB-UVB","Comparison between serum Level of Gelsolin (GSN) in Psoriatic Patients and controls and correlate its level with PASI.",[9,15,19,23],[33],"Methotrexate",[35],{"name":36,"affiliation":37,"role":38},"Moustafa Adam Ali El Taieb, Professor","Dermatology, Venereology and Andrology.Faculty of Medicine, Aswan University","STUDY_CHAIR",[40,46],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Nourhan Salah Mohamed, Resident","CONTACT","+201124152433",null,"dr.nourhan505@gmail.com",{"name":47,"role":42,"phone":48,"phoneExt":44,"email":49},"Mahmoud Ahmed Ali, Lecturer","+201002364902","dr.mahmoudali@aswu.edu.eg",[51],{"facility":52,"status":53,"city":54,"state":44,"zip":44,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Aswan University Hospital","RECRUITING","Aswān","Egypt","EG",{"type":58,"coordinates":59},"Point",[60,61],32.89942,24.09082,{"lat":61,"lon":60},[64,65],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},{"name":66,"role":42,"phone":67,"phoneExt":44,"email":68},"Mohamed Amer Ahmed Abdellatif","+201060394083","mohammed.abdellatif@aswu.edu.eg",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"PRINCIPAL_INVESTIGATOR","Nourhan Salah Mohamed","Resident of Dermatology, Venereology and Andrology","100570822","evaluation-the-effect-of-nb-uvb-and-methotrexate-on-the-level-of-serum-gelsolin-in-psoriatic-patients-100570822",false,"NCT06712238","Evaluation The Effect of NB-UVB and Methotrexate on The Level of Serum Gelsolin in Psoriatic Patients","Inclusion Criteria:\n\n* Patients with moderate to severe plaque psoriasis.\n* No restriction of age, race nor occupation.\n\nExclusion Criteria:\n\n* History of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months.\n* Pregnancy and lactation.\n* Infections.\n* Patients with chronic diseases: hepatic disorders, hematologic diseases, chronic renal failure or cancer.",true,"ALL","15 Years","65 Years",{"count":84,"type":85},48,"ESTIMATED","INTERVENTIONAL",[88],"NA","Psoriasis is a common chronic, immune-mediated, skin disease with a significantly negative impact on patients' quality of life. It is one of papulosquamous diseases defined by erythematous plaques with silvery scales.\n\nThe interplay among cytokines released by dendritic, Th1, Th2, and Th17 cells leads to the clinical manifestations seen in psoriasis. Although discovering novel biomarkers for psoriasis is challenging step., it may play an essential role in diagnosis, severity assessment and prediction of treatment outcome and prognosis of the disease",[91],"Psoriatic Conditions","2024-11-26",{"date":94,"type":95},"2024-12-02","ACTUAL",{"date":97,"type":95},"2024-06-10",{"date":99,"type":85},"2025-06-10",{"name":5,"class":6},1]