[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470969":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":30,"responsibleParty":46,"collaborators":20,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":50,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":20,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Main cohort","EXPERIMENTAL","This is a single-arm study. Samples are collected from consenting donors undergoing surgery for medical purposes.",[13],"Procedure: Hysteroscopy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Hysteroscopy","Samples will be collected from consenting patients undergoing a surgical hysteroscopy for medical purposes",[9],null,[22,27],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Camille Berthelot, PhD","CONTACT","+33186467946","camille.berthelot@pasteur.fr",{"name":28,"role":24,"phone":20,"phoneExt":20,"email":29},"Geoffroy Canlorbe, MD","geoffroy.canlorbe@aphp.fr",[31],{"facility":32,"status":33,"city":34,"state":20,"zip":20,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Pitié salpétrière","RECRUITING","Paris","France","FR",{"type":38,"coordinates":39},"Point",[40,41],2.3488,48.85341,{"lat":41,"lon":40},[44],{"name":45,"role":24,"phone":20,"phoneExt":20,"email":20},"sanson PUPH",{"type":47,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100470969","evolutive-and-functional-bases-of-menstruation-in-women---2-100470969",false,"NCT05412771","Evolutive and Functional Bases of Menstruation in Women - 2","Bases Évolutives Et Fonctionnelles De La Menstruation Chez Les Femmes - 2","EVOMENS-2","Inclusion Criteria:\n\n* Be between 18 and 50 years old.\n* Have mensturation at the time of their participation\n* Have given their written consent\n* Have an indication for surgery of hysteroscopy for removal of a polyp and\u002For fibroid and\u002For endometrial, endometrialctomy for presumed benign pathology and\u002For management of a uterine malformation, scheduled between days 21 and 25 of their menstrual cycle\n* Covered by social security\n\nExclusion Criteria:\n\n* Using an intrauterine device contraceptive method during the study or within the previous three months\n* To be Pregnant at the time of collection\n* Have been pregnant in the three months prior to collection\n* Have had amenorrhoea in the three months prior to collection\n* Have received hormonal treatment within the three months prior to collection\n* Have participated in a clinical study within 3 months prior to collection\n* Have a personal history of breast, ovarian, body or cervical cancer\n* Have a diagnosis of endometriosis\n* Have a diagnosis of adenomyosis\n* Have a diagnosis of Lynch syndrome\n* Undergoing hysteroscopy for a condition other than those listed in the inclusion criteria\n* Women who have not given written consent\n* Women who are breastfeeding\n* Women with a body mass index (BMI) of less than 18.5 or more than 30","FEMALE","18 Years","50 Years",{"count":60,"type":61},20,"ESTIMATED","INTERVENTIONAL",[64],"NA","Menstruation corresponds to the shedding of the uterine lining when fecundation has not occurred. This is a recent evolutionary innovation in primates, and the cellular and genetic changes that led to the acquisition of menstruation are not well understood. Additionally, the uterine lining is poorly characterized in humans across the menstrual cycle, which hinders both evolutionary and medically-relevant analyses.\n\nIn this study, the research team are collecting uterine endometrial tissue samples from female donors undergoing uterine surgery for benign conditions, to profile gene expression and gene regulatory elements in the major cell types that compose the uterine lining during the secretive phase of the menstrual cycle. The investigators will compare this data to similar samples collected from other primates at the same time point in the female hormonal cycle.\n\nThe objective is to identify genes that have acquired novel regulation and\u002For expression patterns and which may be involved in menstruation, as well as better characterize the cellular and molecular pathways at work in the uterine lining of women for translational medicine purposes.",[67],"Menstruation",[69,70],"endometrium","comparative genomics","2025-03-18",{"date":73,"type":74},"2025-03-19","ACTUAL",{"date":76,"type":74},"2022-11-23",{"date":78,"type":61},"2027-10-25",{"name":5,"class":6},1]