[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578352":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":45,"locations":55,"responsibleParty":86,"collaborators":89,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":11,"eligibilityCriteria":98,"healthyVolunteers":99,"sex":100,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":11,"studyType":106,"phases":107,"briefSummary":109,"conditions":110,"keywords":114,"overallStatus":58,"whyStopped":11,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Group","EXPERIMENTAL",null,[13,14,15,16,17,18],"Behavioral: Go\u002FNo-Go Task","Behavioral: Delay discounting task","Behavioral: Mirror Tracing Persistence Task","Behavioral: Spatial Span","Behavioral: Stop Signal Task","Behavioral: Flanker task",[20,25,29,33,37,41],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"BEHAVIORAL","Go\u002FNo-Go Task","A computerized test in which participants are presented with red and green spaceship stimuli. They are told to press the spacebar in response to green spaceships (80% of trials) and withhold their response to red spaceships (20% of trials).",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Delay discounting task","Participants make decisions between smaller, immediate rewards and larger, delayed rewards. The amount of the immediate reward and delay time are manipulated to identify individual delay discounting curves, or how the reward value decreases as a function of delay.",[9],{"type":21,"name":30,"description":31,"armGroupLabels":32,"otherNames":11},"Mirror Tracing Persistence Task","A computerized test in which participants trace a star line drawing with a computer cursor using a trackpad with reversed directional controls. There are increasing levels of difficulty with participants being told they could quit the task during the very hard third star that they try to trace.",[9],{"type":21,"name":34,"description":35,"armGroupLabels":36,"otherNames":11},"Spatial Span","Participants are instructed to attend to a computer screen to keep track of the order in which a happy face stimuli appears in a sequence of boxes positioned on the screen. They are presented with 2 trials at each level of difficulty, increasing from 2 stimuli by 1 additional stimuli per trial until they respond incorrectly for both trials within a level. There are two task conditions, forward and backward span, with the participant responding in the reverse order that the stimuli were presented for backward span.",[9],{"type":21,"name":38,"description":39,"armGroupLabels":40,"otherNames":11},"Stop Signal Task","A computerized test in which participants are presented with a right or left facing arrow and are instructed to press a response button indicating the direction of the arrow. On 25% of the trials, an auditory beep is presented (i.e., stop signal) following the onset of the arrow (i.e., go signal) and participants are instructed to withhold their response when they hear the stop signal.",[9],{"type":21,"name":42,"description":43,"armGroupLabels":44,"otherNames":11},"Flanker task","A computerized test in which a group of arrows are presented on the screen with the central arrow (target) pointing in the same\u002Fopposite direction as the 4 surrounding arrows (flankers). Participants are instructed to respond as quickly and accurately as possible to the central target arrow.",[9],[46,51],{"name":47,"role":48,"phone":49,"phoneExt":11,"email":50},"Keri S Rosch, PhD in Clinical Psychology","CONTACT","443-923-9465","Rosch@KennedyKrieger.org",{"name":52,"role":48,"phone":53,"phoneExt":11,"email":54},"Alyssa C DeRonda, MS in Experimental Psychology","443-923-9258","deronda@kennedykrieger.org",[56,77],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Hugo W. Moser Research Institute at Kennedy Krieger","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-76.61219,39.29038,{"lat":68,"lon":67},[71,75],{"name":72,"role":48,"phone":73,"phoneExt":11,"email":74},"Christine Collins","667-205-4226","KKI.researchadmin@kennedykrieger.org",{"name":47,"role":76,"phone":11,"phoneExt":11,"email":11},"PRINCIPAL_INVESTIGATOR",{"facility":78,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"Kennedy Krieger Institute",{"type":65,"coordinates":80},[67,68],{"lat":68,"lon":67},[83],{"name":84,"role":48,"phone":53,"phoneExt":11,"email":85},"Research Coordinator","CNIR@kennedykrieger.org",{"type":76,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Keri Rosch","Clinical Psychologist\u002FAssociate Professor",[90],{"name":91,"class":92},"National Institute of Mental Health (NIMH)","NIH","100578352","examination-of-the-dynamic-relationships-of-sleep-physical-activity-and-circadian-rhythmicity-with-neurobehavioral-heterogeneity-in-adhd-100578352",false,"NCT06810180","Examination of the Dynamic Relationships of Sleep, Physical Activity, and Circadian Rhythmicity With Neurobehavioral Heterogeneity in ADHD","ADHD Clinical Group. Meet criteria for attention deficit\u002Fhyperactivity disorder (ADHD) according to DSM-5 criteria.\n\nExclusion Criteria:\n\nPrematurity Prenatal exposure to alcohol or other substances Traumatic brain injury Co-occurring neurodevelopmental disorders (e.g., autism spectrum disorder, intellectual disability) Anxiety\u002Fmood disorders Active psychosis Bipolar disorder Conduct disorder Currently taking longer acting psychotropic medications that cannot be discontinued the day before research appointments\n\nControl Group. Does not meet criteria for psychological or neuropsychological disorders Does not meet criteria for intellectual disability Does not meet criteria for a learning disorder\n\nExclusion Criteria:\n\nPrematurity Prenatal exposure to alcohol or other substances Traumatic brain injury Currently taking medications that cannot be discontinued the day before research appointments",true,"ALL","8 Years","12 Years",{"count":104,"type":105},200,"ESTIMATED","INTERVENTIONAL",[108],"NA","Attention deficit\u002Fhyperactivity disorder (ADHD) can present differently in individuals, with some individuals having difficulty with attentional control, hyperactivity, impulsivity, emotion dysregulation, and\u002For neurobehavioral functioning. The factors contributing to these different presentations remain unclear, but altered patterns of physical activity, sleep, and circadian rest\u002Factivity rhythms may play a key role.\n\nThe goal of this study is to leverage wearable technology (i.e., a wristband) to investigate the relationships between physical activity during the day, sleep patterns and disturbances, and 24-hour circadian rest\u002Factivity rhythms with differences in ADHD symptoms, emotion dysregulation, and related brain and behavioral features of attention-deficit\u002Fhyperactivity disorder (ADHD). The investigators hope this study will help improve assessment and intervention for individuals with ADHD by understanding how these factors relate to ADHD symptom expression and associated brain differences in ADHD.\n\nParticipants taking stimulant medication must withhold stimulant medication 24 hours before their research appointment and the morning of their research appointment. Stimulant medication may be restarted after the appointment is complete.\n\nParticipation in this study will require children to complete an initial 2-hour research appointment, two (2) weeks of activity and sleep monitoring at home using a wearable wristband and answering questions sent to a smartphone, and a second 4-hour research appointment after the 2-week period.\n\nDuring the first research appointment, children will complete a cognitive assessment and a practice magnetic resonance imaging (MRI) scan. Parents\u002Flegal guardians will participate in the 30-45-minute sleep device training session with one of the research staff.\n\nDuring the two weeks of activity\u002Fsleep monitoring at home, parents and children will answer questions about their sleep routine, ADHD symptoms, and emotional responding each morning and evening. Parents will be asked to install a questionnaire application on their smartphone. A prompt will be sent to their smartphone multiple times per day reminding parents to complete the brief assessment.\n\nAfter the 2-week period, children will complete a 4-hour research appointment. During this research appointment, children will complete a 60-minute MRI scan and computer-based activities that assess cognitive skills, reward-based decision-making, and frustration tolerance. At the end of the research appointment, children will return the device to our research team. Parents may delete the questionnaire application from their phone at the end of the research appointment.\n\nParticipation will also require parents\u002Flegal guardians to complete questionnaires about their child. Questionnaires will be provided to the primary caregiver by email or at the beginning of their child's first research appointment. Parents agree to complete and return the questionnaires within one month of their child's research appointment.\n\nParents may be provided with additional questionnaires to give to their child's primary schoolteacher. This information is collected to better understand children's abilities, behavior, strengths, and weaknesses.\n\nThere are minimal risks associated with this study. Risks include fatigue, boredom, and mild discomfort.\n\nThere is no cost to participating in this study.\n\nThere is no direct benefit to participants for participating in this study.",[111,112,113],"Attention Deficit Hyperactivity Disorder (ADHD)","Sleep","Physical Activity",[115,116,117],"ADHD","Circadian Rhythms","Ecological Momentary Assessment (EMA)","2026-03-06",{"date":120,"type":121},"2026-03-09","ACTUAL",{"date":123,"type":121},"2025-06-17",{"date":125,"type":105},"2031-03-31",{"name":5,"class":6},2]