[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596769":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":29,"locations":38,"responsibleParty":56,"collaborators":28,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":28,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":40,"whyStopped":28,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Delaware","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Morning","EXPERIMENTAL","Exercise 10 hours after dim-light melatonin onset",[13],"Behavioral: Exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Afternoon","Exercise 15 hours after dim-light melatonin onset",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Evening","Exercise 20 hours after dim-light melatonin onset",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Exercise","A single standardized, in-lab, 30-minute monitored treadmill exercise session",[15,19,9],null,[30,35],{"name":31,"role":32,"phone":33,"phoneExt":28,"email":34},"Freda Patterson, PhD","CONTACT","302-831-6588","fredap@udel.edu",{"name":36,"role":32,"phone":33,"phoneExt":28,"email":37},"Thomas Keiser","tkeiser@udel.edu",[39],{"facility":5,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Newark","Delaware","19713","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-75.74966,39.68372,{"lat":50,"lon":49},[53,54],{"name":36,"role":32,"phone":33,"phoneExt":28,"email":37},{"name":31,"role":55,"phone":28,"phoneExt":28,"email":28},"PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"SPONSOR_INVESTIGATOR","Freda Patterson","Professor","100596769","examining-the-circadian-timing-effects-of-the-hypotensive-response-to-exercise-100596769",false,"NCT07049783","Examining the Circadian Timing Effects of the Hypotensive Response to Exercise","XTIME","Inclusion Criteria:\n\n* 18-39 Years old\n* Resting blood pressure greater than or equal to 120\u002F80 mmHg or less than 140\u002F90 mmHg\n\nExclusion Criteria:\n\n* Diagnosis or history of chronic or autoimmune disease (i.e., cardiovascular, metabolic, renal, endocrine, cancer)\n* Diagnosis or history of sleep disorder (i.e., obstructive sleep apnea, insomnia, restless leg syndrome)\n* Alcohol or drug dependence\n* Elevated risk for sleep disorders\n* Elevated risk for clinical depression\n* Normotensive (blood pressure less than 120\u002F80 mmHg) or stage 2+ hypertension (blood pressure greater than or equal to 140\u002F90 mmHg)\n* Body mass index less than 18.5 or greater than 35 kg\u002Fm2\n* Self-reported use of sleep medications\u002Fsupplements (e.g., melatonin)\n* Self-reported use of medications influencing vascular physiology (e.g., antihypertensive medications, weight loss medications)\n* Highly physically active (greater than or equal to 300 minutes moderate-to-vigorous physical activity per week)\n* Currently pregnant or breastfeeding\n* Current tobacco use (greater than or equal to 1 cigarette in the past month)\n* Nighttime or rotating shift work within the last 3 months\n* Contraindications to aerobic exercise","ALL","18 Years","39 Years",{"count":71,"type":72},30,"ESTIMATED","INTERVENTIONAL",[75],"NA","The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is:\n\n• When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours?\n\nParticipants will:\n\n* Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night\n* Complete 3 supervised treadmill exercise sessions\n\n  * 1 in the biological morning (biological night + 10 hours)\n  * 1 in the biological afternoon (biological night + 15 hours)\n  * 1 in the biological evening (biological night + 20 hours)\n* Complete a 24-hour blood pressure assessment before and after each exercise session",[78,79,80,81],"Young Adults","Hypertension","Post-Exercise Hypotension","Circadian Rhythm",[83,79,84,85],"Young adults","Post-exercise hypotension","Circadian rhythm","2025-08-12",{"date":88,"type":89},"2025-08-17","ACTUAL",{"date":91,"type":89},"2025-07-22",{"date":93,"type":72},"2026-09",{"name":58,"class":6},1]