[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100433333":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":36,"centralContacts":40,"locations":45,"responsibleParty":59,"collaborators":29,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":29,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":29,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":47,"whyStopped":29,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Virginia Commonwealth University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Moderate Intensity, Normal Volume Exercise Training","EXPERIMENTAL","Participants will complete study 1 (HM20020955-1) and then 10 weeks of moderate intensity, normal volume exercise training",[13],"Behavioral: Moderate Intensity, Normal Volume Exercise Training",{"label":15,"type":10,"description":16,"interventionNames":17},"High Intensity, Normal Volume Exercise Training","Participants will complete study 1 (HM20020955-1) and then 10 weeks of high intensity, normal volume exercise training",[18],"Behavioral: High Intensity, Normal Volume Exercise Training",{"label":20,"type":10,"description":21,"interventionNames":22},"Moderate Intensity, High Volume Exercise Training","Participants will complete study 1 (HM20020955-1) and then 10 weeks of moderate intensity, high volume exercise training",[23],"Behavioral: Moderate Intensity, High Volume Exercise Training",[25,30,33],{"type":26,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","Week 1 3 days\u002Fweek for 20 minutes\u002Fday Performed at 70% of heart rate maximum\n\nWeek 2 3 days\u002Fweek for 30 minutes\u002Fday Performed at 70% of heart rate maximum\n\nWeeks 3-10 3 days\u002Fweek for 45 minutes\u002Fday Performed at 70% of heart rate maximum",[9],null,{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":29},"Week 1 3 days\u002Fweek for 31 minutes\u002Fday 10 minute warm up at 50% of heart rate maximum 2 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 7 minute cool down at 50% of heart rate maximum\n\nWeek 2 3 days\u002Fweek for 38 minutes\u002Fday 10 minute warm up at 50% of heart rate maximum 3 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 2 TIMES 7minute cool down at 50% of heart rate maximum\n\nWeeks 3-10 3 days\u002Fweek for 45 minutes\u002Fday 10 minute warm up at 50% of heart rate maximum 4 x 4 minute intervals 4 minutes at 90-95% of heart rate maximum 3 minutes at 70% of heart rate maximum REPEAT 3 TIMES 7 minute cool down at 50% of heart rate maximum",[15],{"type":26,"name":20,"description":34,"armGroupLabels":35,"otherNames":29},"Week 1 5 days\u002Fweek for 20 minutes\u002Fday Performed at 70% of heart rate maximum\n\nWeek 2 5 days\u002Fweek for 30 minutes\u002Fday Performed at 70% of heart rate maximum\n\nWeeks 3-10 5 days\u002Fweek for 45 minutes\u002Fday Performed at 70% of heart rate maximum",[20],[37],{"name":38,"affiliation":5,"role":39},"Ryan Garten, PhD","PRINCIPAL_INVESTIGATOR",[41],{"name":38,"role":42,"phone":43,"phoneExt":29,"email":44},"CONTACT","(804) 828-1948","rsgarten@vcu.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":29},"RECRUITING","Richmond","Virginia","23298","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-77.46026,37.55376,{"lat":57,"lon":56},{"type":60,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100433333","examining-the-impact-of-exercise-training-on-vascular-dysfunction-in-individuals-with-mental-health-disorders---study-2-100433333",false,"NCT04922762","Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 2","Inclusion Criteria:\n\n* apparently healthy and free of overt cardiovascular, pulmonary, or metabolic disease\n* for PTSD group, a score of ≥ 33 on PCL-5 checklist\n* for GAD group, a score of ≥ 10 on the GAD-7 self-report scale and \\\u003C 33 on the PCL-5 checklist\n* for Healthy Control group, a score of ≤ 10 on the GAD-7 self-report scale and \\\u003C 33 on the PCL-5 checklist\n\nExclusion Criteria:\n\n* taking medications that could influence cardiovascular function\n* current smokers who have recently quit smoking\n* illicit drug use or excessive alcohol consumption\n* pregnant women\n* significant calorie restriction or vitamin\u002Fmineral deficiencies\n* limited English proficiency",true,"ALL","18 Years","35 Years",{"count":72,"type":73},360,"ESTIMATED","INTERVENTIONAL",[76],"NA","The purpose of this research study is to examine the effect of various forms of exercise training on blood vessel function in healthy individuals as well as individuals with mental health disorders (posttraumatic stress disorder (PTSD) and\u002For generalized anxiety disorder (GAD)).",[79],"Peripheral Vascular Diseases",[81,82,83,84,85],"cardiovascular disease","vascular function","PTSD","GAD","Oxidant","2025-11-13",{"date":88,"type":89},"2025-11-17","ACTUAL",{"date":91,"type":89},"2021-12-06",{"date":93,"type":73},"2026-12",{"name":5,"class":6},1]