[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629622":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":27,"locations":37,"responsibleParty":54,"collaborators":58,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Illinois at Urbana-Champaign","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-Diabetic","ACTIVE_COMPARATOR","Non-diabetic control group. Will be assigned to all pre-\u002Fpost-testing and complete the 12-week intervention period.",[13],"Other: 12 week progressive exercise training",{"label":15,"type":16,"description":17,"interventionNames":18},"Diabetic group","EXPERIMENTAL","Diagnosed diabetic group. Will complete all pre- and post-testing and the 12-week intervention period.",[13],[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"12 week progressive exercise training","moderate - to - vigorous aerobic and strength-based exercise training will be performed 2-3 times per week for 12 weeks.\n\nStrength Training consists of a 5-minute warm-up on a stationary bike, followed by 1-3 sets on the leg press, leg extension, and leg curl machines. In addition, participants will preform upper body exercises on guided motion machines (seated chest press, shoulder press, seated rows) on alternate training days. Training intensity will gradually increase on each participants comfort level.\n\nEndurance training will be performed on a stationary bike. Exercise intensity will be controlled by heart rate and rate of perceived exertion (RPE) using the Borg's original scale (6-20 points). Weeks 1--3 will be at 50-60% of max heart rate for 30 minutes; weeks 4-6 will be at 50-60% of max heart rate for 40 minutes; weeks 7-9 will be 60-70% of max heart rate for 50 minutes; and weeks 10-12 will be at 60-70% of max heart rate for 60 minutes.",[15,9],[25],"12-week progressive training",null,[28,33],{"name":29,"role":30,"phone":31,"phoneExt":26,"email":32},"Nicholas Burd (Professor), PhD","CONTACT","2172440970","naburd@illinois.edu",{"name":34,"role":30,"phone":35,"phoneExt":26,"email":36},"Gena Irwin (Research Assistant), M.S","3608883281","genai2@illinois.edu",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Freer Hall - University of Illinois","RECRUITING","Urbana","Illinois","61801","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-88.20727,40.11059,{"lat":50,"lon":49},[53],{"name":29,"role":30,"phone":31,"phoneExt":26,"email":32},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Nicholas Burd","Professor",[59],{"name":60,"class":6},"American Diabetes Association","100629622","exercise-and-protein-efficiency-in-t2d-100629622",false,"NCT07477067","Exercise and Protein Efficiency in T2D","Exercise Impact on Dietary Protein Efficiency in Older Adults With Type 2 Diabetes","ADA","Inclusion Criteria:\n\n* At least 65 years old\n* Body mass index: 25-40 kg\u002Fm\\^2\n* Female: Waist to hip ratio \\>0.8\n* Male: Waist to hip ratio \\>1.0\n* Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months\n\nT2D group:\n\n-Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) \\>6.5%\n\nControl group:\n\n-Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg\u002FdL (5.5mmol)\n\nExclusion Criteria:\n\n* Uncontrolled diabetes (evidence of HbA1c \\> 10%, prescription of insulin)\n* Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening\n* Statins\n* Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic\u002Fcatabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.\n* Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.",true,"ALL","65 Years",{"count":73,"type":74},30,"ESTIMATED","INTERVENTIONAL",[77],"NA","In this randomized controlled trial, 30 older adults (aged\\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.",[80,81],"Type 2 Diabetes","Control Condition",[80,83,84,85],"Obesity","Exercise Intervention","Protein Metabolism","2026-04-27",{"date":88,"type":89},"2026-04-29","ACTUAL",{"date":91,"type":89},"2026-02-09",{"date":93,"type":74},"2028-07-01",{"name":5,"class":6},1]