[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100445363":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":49,"centralContacts":54,"locations":64,"responsibleParty":80,"collaborators":34,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":84,"sex":90,"minAge":91,"maxAge":34,"enrollmentInfo":92,"targetDuration":34,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":66,"whyStopped":34,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Sunnybrook Health Sciences Centre","OTHER",[8,15,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise primed tDCS","EXPERIMENTAL","Individuals randomized to this group will receive exercise at University Health Network-Toronto Rehabilitation Institute followed by active tDCS.",[13,14],"Other: tDCS","Other: Exercise",{"label":16,"type":6,"description":17,"interventionNames":18},"Exercise primed Sham stimulation","Individuals randomized to this group will receive exercise at University Health Network-Toronto Rehabilitation Institute followed by sham tDCS.",[14,19],"Other: Sham stimulation",{"label":21,"type":6,"description":22,"interventionNames":23},"Treatment as usual (exercise education) & tDCS","Individuals randomized to this group will receive routine advice about physical activity, and active tDCS.",[13,24],"Other: Treatment as usual",{"label":26,"type":6,"description":27,"interventionNames":28},"Treatment as usual (exercise education) & sham stimulation","Individuals randomized to this group will receive routine advice about physical activity, and sham tDCS.",[19,24],[30,35,39,43],{"type":6,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"tDCS","All participants randomized to tDCS will receive active tDCS",[9,21],null,{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Exercise","Participants will exercise at Toronto Rehab.",[16,9],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":34},"Sham stimulation","The same procedure for tDCS will be used for the sham condition, except without active current.",[16,26],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"Treatment as usual","Exercise education\u002F treatment as usual will include routine advice about physical activity.",[26,21],[48],"Exercise education",[50],{"name":51,"affiliation":52,"role":53},"Krista Lanctôt, PhD","Sunnybrook Research Institute","PRINCIPAL_INVESTIGATOR",[55,61],{"name":56,"role":57,"phone":58,"phoneExt":59,"email":60},"Mehreen Siddiqui","CONTACT","416-480-6100","63185","mehreen.siddiqui@sri.utoronto.ca",{"name":62,"role":57,"phone":58,"phoneExt":59,"email":63},"Kate Survilla","kate.survilla@sri.utoronto.ca",[65],{"facility":5,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"RECRUITING","Toronto","Ontario","M4N 3M5","Canada","CA",{"type":73,"coordinates":74},"Point",[75,76],-79.39864,43.70643,{"lat":76,"lon":75},[79],{"name":56,"role":57,"phone":58,"phoneExt":59,"email":60},{"type":81,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100445363","exercise-as-a-primer-for-brain-stimulation-in-vascular-cognitive-impairment-no-dementia-vcind-100445363",false,"NCT05079464","Exercise as a Primer for Brain Stimulation in Vascular Cognitive Impairment No Dementia (VCIND)","Exercise as a Primer for Excitatory Stimulation Study in Vascular Cognitive Impairment No Dementia (EXPRESS-V)","EXPRESS-V","Inclusion Criteria:\n\n* ≥50 years of age; females must be post-menopausal\n* Presence of cerebrovascular and\u002For cardiovascular risk factors or coronary artery disease\n* Montreal Cognitive Assessment (MoCA) \\\u003C27\n* Sufficiently proficient in English\n* Must be able to exercise at a moderate intensity level\n* Presence of modest deficits (1 standard deviation below population norm) in one of the following domains: executive function, verbal memory, working memory, or visuospatial memory\n\nExclusion Criteria:\n\n* History of stroke\n* Change in psychotropics within the last 4 weeks\n* Current benzodiazepine use due\n* Metal implants that would preclude safe use of tDCS or neuroimaging\n* Significant neurological or psychiatric conditions (current major depressive disorder, bipolar disorder, schizophrenia)\n* MoCA \\\u003C18 and\u002For clinical diagnosis of dementia\n* Any medical contraindications to exercise","ALL","50 Years",{"count":93,"type":94},64,"ESTIMATED","INTERVENTIONAL",[97],"NA","People with vascular conditions are at risk of having memory problems, and these memory problems increase the risk for further cognitive decline. Brain stimulation has been used to improve mood and memory. Transcranial direct current stimulation (tDCS) is believed to work best on brain cells that are active or \"primed\" before stimulation. The purpose of this study is to compare the effects of exercise and tDCS on memory performance in patients who have completed cardiac rehabilitation and are at risk of cognitive decline.",[100,101],"Vascular Cognitive Impairment","Mild Cognitive Impairment",[103,31,104,105,106,107],"transcranial direct current stimulation","exercise","cognition","vascular cognitive impairment no dementia","vascular mild cognitive impairment","2026-04-10",{"date":110,"type":111},"2026-04-13","ACTUAL",{"date":113,"type":111},"2021-11-22",{"date":115,"type":94},"2026-12",{"name":5,"class":6},1]