[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537405":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":36,"locations":41,"responsibleParty":65,"collaborators":68,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":44,"whyStopped":25,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"University of Southern Denmark","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Progressive high-load resistance training program performed twice weekly for 12 weeks",[13],"Other: High-load strength training for the knee",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard care","ACTIVE_COMPARATOR","The standard care group will receive instructions on a neuromuscular training program with focus on knee stability and function performed at low intensities to be conducted twice weekly for 12 weeks",[19],"Other: Neuromuscular training for the knee",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Neuromuscular training for the knee","The exercise programme includes exercises identified in literature to target muscles around the knee.",[15],null,{"type":6,"name":27,"description":23,"armGroupLabels":28,"otherNames":25},"High-load strength training for the knee",[9],[30,33],{"name":31,"affiliation":5,"role":32},"Behnam Liaghat, PhD","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":35},"Jonas B Thorlund, PhD","STUDY_DIRECTOR",[37],{"name":31,"role":38,"phone":39,"phoneExt":25,"email":40},"CONTACT","+4526826801","bliaghat@health.sdu.dk",[42,58],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Physiotherapy Clinics Region of Southern Denmark","RECRUITING","Odense","Fyn","5000","Denmark","DK",{"type":51,"coordinates":52},"Point",[53,54],10.38831,55.39594,{"lat":54,"lon":53},[57],{"name":31,"role":38,"phone":39,"phoneExt":25,"email":40},{"facility":5,"status":44,"city":45,"state":46,"zip":59,"country":48,"countryCode":49,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"5230",{"type":51,"coordinates":61},[53,54],{"lat":54,"lon":53},[64],{"name":31,"role":38,"phone":39,"phoneExt":25,"email":40},{"type":32,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Behnam Liaghat","Assistant Professor",[69,72],{"name":70,"class":71},"Independent Research Fund Denmark","INDUSTRY",{"name":73,"class":6},"Odense Patient Data Explorative Network","100537405","exercise-in-patients-with-hypermobile-joints-and-knee-pain-100537405",false,"NCT06277401","Exercise in Patients With Hypermobile Joints and Knee Pain","High-load Resistance Training Compared With Usual Care for Treatment of Painful Knee Joint Hypermobility in Young Adults: A Randomised Controlled Trial (the HIPEr-Knee Study)","HIPEr-Knee","Inclusion criteria\n\n* Persistent knee pain for ≥ 3 months (self-reported)\n* Knee pain ≥ 30mm during the last week using a 0-100 mm visual analogue scale (VAS; 0=no pain and 100=worst imaginable pain) (self-reported)\n* Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive ≥ 2\u002F5) (self-reported)\n* Local knee joint hypermobility using the passive hyperextension of the knee in standing (positive \\> 10 degrees of hyperextension) and confirmed in supine lying (heel resting on 20 cm high block on the bench surface), with passive knee hyperextension (positive \\> 10 degrees) (objectively measured)\n\nExclusion criteria\n\n* Diagnosed with patellar tendinopathy\n* Pregnancy or childbirth within the past year (due to increased levels of relaxin that could affect joint stability)\n* Knee surgery within the past year\n* Participation in regular structured resistance training within the past six months\n* Inability to speak and understand Danish.\n* All types of Ehlers-Danlos syndrome\n* Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias\n* Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis; Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome\n* Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis","ALL","18 Years","45 Years",{"count":86,"type":87},90,"ESTIMATED","INTERVENTIONAL",[90],"NA","Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.",[93,94,95],"Hypermobility, Joint","Hypermobility Syndrome","Knee Discomfort",[97,98,99,100],"Hypermobility","Knee pain","Treatment","Randomised controlled trial","2026-04-28",{"date":103,"type":104},"2026-04-29","ACTUAL",{"date":106,"type":104},"2024-02-21",{"date":108,"type":87},"2027-12",{"name":5,"class":6},2]