[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605811":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":35,"centralContacts":35,"locations":36,"responsibleParty":56,"collaborators":35,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":35,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":35,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":35,"overallStatus":39,"whyStopped":35,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Affiliated Hospital of Nantong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Basic Treatment Group","ACTIVE_COMPARATOR","Patients with HFrEF and chronic kidney dysfunction receive 6 months of basic drug treatment, with regular follow-up during the period.",[13],"Drug: Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction",{"label":15,"type":16,"description":17,"interventionNames":18},"Exercise Rehabilitation Group","EXPERIMENTAL","Patients with HFrEF and chronic kidney dysfunction receive 6 months of basic drug treatment combined with home-based exercise rehabilitation. Exercise prescriptions are formulated based on cardiopulmonary exercise test results (using heart rate at anaerobic threshold) or 6MWT (for those unable to complete cardiopulmonary exercise tests), with follow-up conducted throughout the period.",[13,19],"Behavioral: Home-based Personalized Exercise Rehabilitation",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Standardized Basic Drug Therapy for HFrEF with Chronic Kidney Dysfunction","Participants receive standardized basic drug therapy for HFrEF and chronic kidney dysfunction in accordance with clinical practice guidelines. Medications include but are not limited to angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), beta-blockers, mineralocorticoid receptor antagonists (MRAs), and diuretics, with dosage adjustments based on individual patient conditions.",[9,15],[27],"Guideline-Based Basic Medication Regimen for CRS Patients with HFrEF",{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"BEHAVIORAL","Home-based Personalized Exercise Rehabilitation","On the basis of basic drug treatment, participants in the exercise rehabilitation group receive personalized home-based exercise prescriptions. Prescriptions are developed according to cardiopulmonary exercise test results (using heart rate at anaerobic threshold) or 6MWT (for those unable to complete cardiopulmonary exercise tests). The 6-month exercise program includes aerobic exercises (e.g., brisk walking, cycling), with intensity, duration, and frequency adjusted based on individual tolerance and progress.",[15],[34],"Home-Centered Customized Exercise Program for CRS with HFrEF",null,[37],{"facility":38,"status":39,"city":40,"state":41,"zip":35,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"The Affiliated Hospital of Nantong University","RECRUITING","Nantong","Jiangsu","China","CN",{"type":45,"coordinates":46},"Point",[47,48],120.87472,32.03028,{"lat":48,"lon":47},[51],{"name":52,"role":53,"phone":54,"phoneExt":35,"email":55},"Pan","CONTACT","+86 13906291842","dr.phy@qq.com",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"SPONSOR_INVESTIGATOR","Haiyan Pan","Professor and Chief Physician, Department of Cardiology","100605811","exercise-rehabilitation-for-cardiorenal-syndrome-in-hfref-patients-100605811",false,"NCT07167368","Exercise Rehabilitation for Cardiorenal Syndrome in HFrEF Patients","Efficacy and Safety of Home-Based Exercise Rehabilitation in Patients With Cardiorenal Syndrome Complicated by Chronic Heart Failure With Reduced Ejection Fraction (HFrEF): A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with chronically stable HFrEF complicated by kidney dysfunction (eGFR \\\u003C 90 mL\u002Fmin\u002F1.73m²)\n* NYHA class II-III\n* Low risk in exercise risk assessment\n* Aged 18-75 years\n\nExclusion Criteria:\n\n* Uncontrolled hypertension\n* Severe arrhythmias (including frequent ventricular premature contractions, ventricular tachycardia, rapid atrial fibrillation, sick sinus syndrome, and second-degree or higher atrioventricular block)\n* Obstructive hypertrophic cardiomyopathy\n* Moderate to severe stenotic valvular heart disease\n* Deep vein thrombosis or pulmonary embolism\n* History of syncope\n* Severe anemia\n* Abnormal thyroid function\n* Severe pulmonary diseases\n* Mental illnesses\n* Osteoarticular or muscular diseases that impede rehabilitation training","ALL","18 Years","75 Years",{"count":71,"type":72},60,"ESTIMATED","INTERVENTIONAL",[75],"NA","This study aims to investigate the efficacy and safety of exercise rehabilitation in patients with cardiorenal syndrome (CRS).\n\nBuilding on previous research demonstrating that exercise rehabilitation can effectively improve cardiac function and cardiopulmonary endurance in patients with chronic heart failure, this study will further explore its role in the context of CRS, a condition where such effects remain understudied. CRS patients typically exhibit reduced cardiopulmonary endurance, with significantly lower peak oxygen uptake (VO₂ peak) and 6-minute walk test (6MWT) distance compared to non-CRS patients.\n\nAdults aged 18-75 with chronic heart failure with reduced ejection fraction (HFrEF) complicated by chronic renal insufficiency will be enrolled and randomly assigned to two groups: 1. Basic treatment group: 30 patients receive only basic drug treatment for 6 months. 2. Exercise rehabilitation group: 30 patients receive basic drug treatment combined with home-based exercise rehabilitation for 6 months (with personalized exercise prescriptions formulated based on cardiopulmonary exercise test results or 6MWT for those unable to complete the former). The study will explore the efficacy and safety of exercise rehabilitation in the prevention and management of CRS by comparing changes in target biomarkers, renal function indicators, cardiac function indicators, cardiopulmonary exercise test results, Minnesota Living with Heart Failure Questionnaire scores, and the incidence of adverse events before and after treatment between the two groups.\n\nThe participants will:\n\nComplete cardiopulmonary exercise tests or 6MWT before treatment initiation. Receive basic drug treatment; those in the exercise rehabilitation group will additionally perform home-based exercise rehabilitation according to the exercise prescription.\n\nAttend regular follow-up visits within 6 months. Undergo assessments of related indicators (biomarkers, renal function, cardiac function, etc.) before and after treatment.",[78],"Cardiorenal Syndrome","2026-02-24",{"date":81,"type":82},"2026-02-27","ACTUAL",{"date":84,"type":82},"2025-09-15",{"date":86,"type":72},"2027-12-31",{"name":58,"class":6},1]