[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053392":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":56,"collaborators":18,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":18,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University of Illinois at Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise rehabilitation program","EXPERIMENTAL","• Participants will take part in a personalized, one-hour, one-on-one muscle therapy session, two days a week, for 6 months.",[13],"Behavioral: Exercise rehabilitation program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","• Participants will complete the study measures on three separate occasions and will have the option to complete the exercise rehabilitation intervention once the study reaches completion.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","* The sessions will consist of a customized low-impact, resistance-base rehabilitation regime to increase muscle strength and functionality by focusing on isolating each targeted muscle, without increasing the participant's fatigue or pain level.\n* The goal of phase one will be to start muscle activation without increasing fatigue or pain. Low intensity, single set of 30-35 repetitions for each of the targeted muscles will be performed by the participants, followed by stretching; the goal of phase two will be to progressively develop muscle strength, without increasing pain or fatigue. A single set of 20-25 repetitions for each muscle will be prescribed, followed by stretching; during phase three, the emphasis will be on further development of muscle strength, function, and endurance.",[9],[25],"GH Method",[27],{"name":28,"affiliation":5,"role":29},"Enrico Benedetti, MD","PRINCIPAL_INVESTIGATOR",[31,35],{"name":28,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","312-355-1493","enrico@uic.edu",{"name":36,"role":32,"phone":37,"phoneExt":18,"email":38},"Ilaria Santi","312-285-9653","isanti@uic.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Chicago","Illinois","60612","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-87.65005,41.85003,{"lat":51,"lon":50},[54],{"name":28,"role":32,"phone":55,"phoneExt":18,"email":34},"312-636-7778",{"type":29,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Enrico Benedetti","Department Head","100053392","exercise-rehabilitation-program-in-ms-who-use-wheelchairs-as-a-primary-mobility-device-100053392",false,"NCT06410261","Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary Mobility Device","Randomized Pilot Study Evaluating the Effect of a 6-Month Exercise Rehabilitation Program on Physical and Cognitive Function in Persons With MS Who Use Wheelchairs as a Primary Mobility Device","MSGH","Inclusion Criteria:\n\n* diagnosis of MS\n* age above 18 years\n* no relapse within last 30 days\n* use of wheelchair for mobility in the community\n* ability to walk at least 50 feet (or 65 steps) using an assistive device\n* low risk for contraindications of physical activity indicated by no more than a single \"yes\"\n* response on the Physical Activity Readiness Questionnaire (PAR-Q)\n* willingness to complete the assessments and undergo randomization\n\nExclusion Criteria:\n\n* no diagnosis of MS\n* less than 18 years of age\n* not relapse-free within the last 30 days\n* no use of wheelchair as primary mobility device\n* no ability to walk for at least 50 feet (or 65 steps)\n* high risk for contraindications based on more than a single \"yes\" response on the PAR-Q\n* not willing to complete the testing procedures and undergo randomization","ALL","18 Years",{"count":70,"type":71},24,"ESTIMATED","INTERVENTIONAL",[74],"NA","Approximately 50% of people with multiple sclerosis (MS) use a wheelchair within 30 years of the initial diagnosis. Wheelchair use in MS is often associated with fatigue as a consequence of muscle weakness. Indeed, fatigue, a prevalent consequence of MS, often becomes debilitating and exhausts energetic resources when carrying-out tasks of daily life and\u002For interacting with the community, as these require ambulatory mobility. This experience of excessive fatigue has its roots in muscle weakness and results in reliance on a wheelchair for mobility, and the dependency on a wheelchair may further reduce muscular strength, particularly of the lower extremities. We propose that wheelchair users with MS can increase muscular strength through a personalized exercise rehabilitation, and this in turn will improve ambulatory performance and possibly reduce fatigue. To date, no research has examined the effects of this specific exercise rehabilitation program (GH method) on physical function and other disease-related outcomes in persons with MS who use wheelchairs as a primary mobility device.",[77],"Multiple Sclerosis",[79,80,81,82],"Exercise","Rehabilitation","Physical function","Cognition","2026-07-10",{"date":85,"type":86},"2026-07-13","ACTUAL",{"date":88,"type":86},"2024-04-29",{"date":90,"type":71},"2027-07-31",{"name":5,"class":6},1]