[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505115":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":61,"centralContacts":65,"locations":71,"responsibleParty":88,"collaborators":10,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":10,"eligibilityCriteria":96,"healthyVolunteers":93,"sex":97,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":10,"studyType":103,"phases":10,"briefSummary":104,"conditions":105,"keywords":10,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Lean Group",null,"Participants with body mass index 20-25 kg\u002Fm\\^2 will complete an outpatient study visit (body composition, blood draw, treadmill test, strength test) and an inpatient visit (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).",[13,14,15,16,17,18,19],"Diagnostic Test: Treadmill Test","Diagnostic Test: Strength Test","Diagnostic Test: Dual-Energy X-Ray Absorptiometry","Procedure: Muscle Biopsy","Procedure: Fat Biopsy","Diagnostic Test: Resting Energy Expenditure","Diagnostic Test: Magnetic resonance imaging",{"label":21,"type":10,"description":22,"interventionNames":23},"Obese Group","Participants with body mass index 30-45 kg\u002Fm\\^2 will complete an outpatient study visit (body composition, blood draw, treadmill test, strength test) and an inpatient visit (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).",[13,14,15,16,17,18,19],[25,30,34,40,45,49,55],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"DIAGNOSTIC_TEST","Treadmill Test","Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).",[9,21],{"type":26,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Strength Test","Measure the strength of leg muscles by kicking against a machine with resistance.",[9,21],{"type":26,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Dual-Energy X-Ray Absorptiometry","Body composition measurement.",[9,21],[39],"DEXA",{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"PROCEDURE","Muscle Biopsy","Obtain a small piece of muscles from the upper part of the legs",[9,21],{"type":41,"name":46,"description":47,"armGroupLabels":48,"otherNames":10},"Fat Biopsy","Fat sample taken from abdomen",[9,21],{"type":26,"name":50,"description":51,"armGroupLabels":52,"otherNames":53},"Resting Energy Expenditure","Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.",[9,21],[54],"REE",{"type":26,"name":56,"description":57,"armGroupLabels":58,"otherNames":59},"Magnetic resonance imaging","MRI on upper leg to look at fat and muscle",[9,21],[60],"MRI",[62],{"name":63,"affiliation":5,"role":64},"Ian Lanza, PhD","PRINCIPAL_INVESTIGATOR",[66],{"name":67,"role":68,"phone":69,"phoneExt":10,"email":70},"Rachel Passehl","CONTACT","507-255-8112","Passehl.Rachel@mayo.edu",[72],{"facility":73,"status":74,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":86},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":81,"coordinates":82},"Point",[83,84],-92.4699,44.02163,{"lat":84,"lon":83},[87],{"name":67,"role":68,"phone":69,"phoneExt":10,"email":70},{"type":64,"investigatorFullName":89,"investigatorTitle":90,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ian R. Lanza","Principal Investigator","100505115","exercise-response-in-humans-with-obesity-100505115",false,"NCT05857150","Exercise Response in Humans With Obesity","Inclusion Criteria:\n\n* Obese men and women ≥ 20 and ≤ 45 years of age.\n\nExclusion Criteria:\n\n* Diabetes or fasting plasma glucose \\>126 mg\u002FdL\n* Anemia (female subjects hemoglobin of \\\u003C11 g\u002Fdl and male subjects hemoglobin \\\u003C12 g\u002Fdl)\n* Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)\n* Renal failure (serum creatinine \\> 1.5mg\u002Fdl)\n* Chronic active liver disease defined as aspartate aminotransferase (AST)\\>144 IU\u002FL or alanine transaminase (ALT) \\>165 IU\u002FL)\n* Oral warfarin group medications or history of blood clotting disorders.\n* Smoking\n* Pregnancy or breastfeeding\n* Alcohol consumption greater than 2 glasses\u002Fday or other substance abuse\n* Untreated or uncontrolled hypothyroidism\n* Debilitating chronic disease (at the discretion of the investigators)","ALL","20 Years","45 Years",{"count":101,"type":102},120,"ESTIMATED","OBSERVATIONAL","This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.",[106],"Obese","2025-08-22",{"date":109,"type":110},"2025-08-29","ACTUAL",{"date":112,"type":110},"2023-09-22",{"date":114,"type":102},"2029-07",{"name":5,"class":6},1]