[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100326299":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":28,"centralContacts":32,"locations":39,"responsibleParty":56,"collaborators":11,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":11,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":42,"whyStopped":11,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"University Hospital, Lille","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Training","EXPERIMENTAL",null,[13],"Behavioral: Exercise Training Procedure",{"label":15,"type":6,"description":11,"interventionNames":16},"Control",[17],"Behavioral: Normal life procedure",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"BEHAVIORAL","Exercise Training Procedure","Exercise training: 3 sessions - 2 supervised and 1 unsupervised - per week of 30-60 min at 65% - 80% of maximum heart rate (4 months)",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Normal life procedure","No supervised exercise training during the 4 month period.",[15],[29],{"name":30,"affiliation":5,"role":31},"Anne Vambergue, MD,Phd","PRINCIPAL_INVESTIGATOR",[33],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Anne Vambergue, MD,PhD","CONTACT","320444184","+33","anne.vambergue@chu-lille.fr",[40],{"facility":41,"status":42,"city":43,"state":11,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hop Claude Huriez Chu Lille","RECRUITING","Lille","59037","France","FR",{"type":48,"coordinates":49},"Point",[50,51],3.05512,50.63391,{"lat":51,"lon":50},[54],{"name":11,"role":35,"phone":55,"phoneExt":11,"email":11},"0320445962",{"type":57,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100326299","exercise-training-and-endothelial-function-in-type-1-diabetes-100326299",false,"NCT03528226","Exercise Training and Endothelial Function in Type 1 Diabetes","Impact of Exercise Training on Endothelial Function in Adults With Type 1 Diabetes","EVaDia","Inclusion Criteria:\n\n* Covered by social security\n* With a T1Diabete, diagnosed for at least 1 year, and free from macrovascular and microvascular diabetic complications.\n\nExclusion Criteria:\n\n* type 1 diabetes diagnoses for less than 1 year\n* MODY diabetes, mitochondrial diabetes or type 2 diabetes\n* presence of macrovascular and\u002For microvascular diabetic complications (retinopathy, nephropathy, neuropathy ,…)\n* Obesity (Body Mass Index \\> 30 kg\u002Fm²\n* Smokers\n* Hypertension\n* Disabling painful discomfort for trunk, upper or lower limb movements\n* Active chronic disease or in remission (excluding type 1 diabetes)\n* Head trauma in the past","ALL","18 Years","50 Years",{"count":70,"type":71},34,"ESTIMATED","INTERVENTIONAL",[74],"NA","Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological interventions to improve endothelial function appears fundamental.\n\nIn this randomized controlled trial, the effects of exercise training on endothelial function will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity and their possible neurometabolic consequences.\n\nAn improvement in vascular function, particularly endothelium-dependent, as well as in neurometabolic profile, through this non-pharmacological strategy is expected",[77],"Type1diabetes",[79,80,81,82],"Type 1 diabetes","endothelial function","exercise training","physical activity","2026-05-13",{"date":85,"type":86},"2026-05-14","ACTUAL",{"date":88,"type":86},"2019-11-12",{"date":90,"type":71},"2028-11",{"name":5,"class":6},1]