[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627596":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":35,"responsibleParty":55,"collaborators":59,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":25,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of Copenhagen","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mitochondrial Myopathy","EXPERIMENTAL","Individuals with myopathy caused by mutations in nuclear or mitochondrial DNA",[13],"Behavioral: Unilateral high-intensity interval training (HIIT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Healthy controls","ACTIVE_COMPARATOR","Control subjects matched for age, sex and BMI",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Unilateral high-intensity interval training (HIIT)","Participants will undergo ten sessions of HIIT of the leg randomized to the intervention while the inactive leg serves as the control leg",[15,9],null,[27,32],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Tue L Nielsen, MD","CONTACT","+45 3545 8748","tue.leth.nielsen.01@regionh.dk",{"name":33,"role":29,"phone":25,"phoneExt":25,"email":34},"Lykke Sylow, Ass.prof","lykkesylow@sund.ku.dk",[36],{"facility":37,"status":38,"city":39,"state":25,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"University of Copenhagen, Dept of Biomedical Sciences","RECRUITING","Copenhagen","DK-2100","Denmark","DK",{"type":44,"coordinates":45},"Point",[46,47],12.56553,55.67594,{"lat":47,"lon":46},[50,52],{"name":33,"role":29,"phone":51,"phoneExt":25,"email":34},"0045 20955250",{"name":53,"role":29,"phone":25,"phoneExt":25,"email":54},"Johanne Modvig, M.Sc.","johanne.modvig@sund.ku.dk",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Lykke Sylow","PhD, group leader",[60],{"name":61,"class":6},"Rigshospitalet, Denmark","100627596","exercise-training-effects-on-muscle-function-in-adults-with-mitochondrial-myopathy-100627596",false,"NCT07450690","Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy","Deciphering Muscle-Nerve Communication Via Mitochondrial Myopathy Insights: Exploring the Effects of Exercise Training","MM-EX","Eligibility criteria for Mitochondrial Myopathy-group:\n\nInclusion Criteria\n\n* Known mtDNA or nuclear (nDNA) mutations\n* Age above or equal to 18 years\n\nExclusion Criteria:\n\n* Medical conditions which deem the MM patient unfit to complete the study\n* Current use of medications known to interact with outcome measures. (see below)\n* Pregnancy\n* The participant is for any other reason unlikely to complete the study\n\nInclusion Criteria for healthy controls\n\n* Age above or equal to 18 years\n\nExclusion Criteria:\n\n* Chronic medical conditions suspected to influence outcome measures\n* Frequent use of medicine\n* Pregnancy\n* The participant is for any other reason unlikely to complete the study",true,"ALL","18 Years",{"count":74,"type":75},22,"ESTIMATED","INTERVENTIONAL",[78],"NA","The goal of this observational study is to learn how exercise training affects molecular processes in skeletal muscle in adults with mitochondrial myopathy, compared with healthy adults.\n\nThe main questions it aims to answer are:\n\n* How does exercise training affect mitochondrial activity and energy production pathways in skeletal muscle in people with mitochondrial myopathy?\n* How does exercise training affect molecular signals related to muscle growth, stress responses, and muscle-nerve communication in people with mitochondrial myopathy?\n\nResearchers will compare the trained leg to the untrained leg within the same participant, and also compare responses between participants with mitochondrial myopathy and healthy control participants, to see how molecular responses to exercise differ between groups.\n\nThe participants will:\n\n* Complete a 3-4-week supervised exercise training program using one leg.\n* Undergo muscle biopsies from both the trained and untrained leg.\n* Complete basic muscle strength and physical function tests.",[81,9],"Mitochondrial Diseases",[83,84,85,86,87],"Exercise training","Mitochondrial function","Skeletal Muscle","Neuromuscular Junction","Muscle Plasticity","2026-03-01",{"date":90,"type":91},"2026-03-05","ACTUAL",{"date":93,"type":91},"2026-01-09",{"date":95,"type":75},"2030-10-30",{"name":5,"class":6},1]